scholarly journals Imaging features and clinical course of undifferentiated round cell sarcomas with CIC-DUX4 and BCOR-CCNB3 translocations

2020 ◽  
Author(s):  
Emily J. Brady ◽  
Meera Hameed ◽  
William D. Tap ◽  
Sinchun Hwang
Keyword(s):  
Clinical Course ◽  
Imaging Features ◽  
Round Cell

Characteristic imaging features of desmoplastic small round cell tumour

2012 ◽  
Vol 43 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Vandan Caur Arora ◽  
Anita P. Price ◽  
Stephen Fleming ◽  
Michael J. Sohn ◽  
Heather Magnan ◽  
...  
Keyword(s):  
Cell Tumour ◽  
Imaging Features ◽  
Round Cell ◽  
Small Round Cell ◽  
Characteristic Imaging ◽  
Round Cell Tumour ◽  
Small Round Cell Tumour

Aspergillus pachymeningitis mimicking nasopharyngeal carcinoma

2010 ◽  
Vol 125 (1) ◽  
pp. 103-107 ◽  
Author(s):  
H S Chan ◽  
H Y Yuen ◽  
W K Ng ◽  
A C Vlantis ◽  
A T Ahuja ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
World Literature ◽  
Clinical Course ◽  
Rare Condition ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Radiological Findings ◽  
Cranial Nerve Palsies ◽  
The World ◽  
Multiple Cranial Nerve

AbstractObjectives:We report a case of otogenic fungal pachymeningitis in a diabetic patient who presented with multiple cranial nerve palsies and nasopharyngeal swelling.Methods:We present a case report, we describe the investigations, management and clinical course of fungal pachymeningitis, and we present a review of the world literature on fungal and non-fungal pachymeningitis.Results:To our knowledge, this is the first report of fungal pachymeningitis with magnetic resonance imaging features suggestive of nasopharyngeal carcinoma. It is also the first reported case with aspergillus cultured from both a dural biopsy and the ear canal.Conclusion:Fungal pachymeningitis is a rare condition which may present to otorhinolaryngologists. Its clinical and radiological findings can be confused with those of nasopharyngeal carcinoma; fungal pachymeningitis should thus be included in the differential diagnosis of nasopharyngeal carcinoma.

scholarly journals Acute bacterial nephritis. A descriptive study of an underdiagnosed entity

2020 ◽  
Vol 80 (3) ◽  
pp. 1-10
Author(s):  
Pedro Antonio Madero-Morales ◽  
Rigoberto Pallares-Méndez ◽  
Rodrigo Romero-Mata ◽  
Guillermo Vizcarra-Mata ◽  
Andrés Guillén-Lozoya
Keyword(s):  
Acute Pyelonephritis ◽  
Clinical Characteristics ◽  
Clinical Course ◽  
Case Series ◽  
Therapy Response ◽  
Time Frame ◽  
Clinical Findings ◽  
Imaging Features ◽  
Imaging Studies ◽  
Retrospective Case

Background: Acute bacterial nephritis is an infectious process diagnosed through imaging studies. The clinical course of the disease has been shown to be more aggressive than acute pyelonephritis. It continues to be underdiagnosed, thus there are few studies on the entity in the literature. Objective: To describe the clinical characteristics and imaging features of acute bacterial nephritis, as well as its clinical course. Design: A descriptive, retrospective case series was conducted. Materials and methods: Thirty-two cases of acute bacterial nephritis in patients admitted to the hospital within the time frame of 2009 to 2016 were reviewed. The patients’ clinical characteristics upon admission were registered, as well as inpatient clinical progression, culture results, and antibiotic therapy response. The imaging studies were re-evaluated and the diagnostic consistency with either the focal or multifocal disease presentation was confirmed. Results: Cases predominated in women (n=29, 90.62%) and the most frequently associated comorbidities were diabetes (n=16, 50%) and obesity (n=9, 28.25%). The most important clinical findings upon admission were fever (n=15, 46.87%) and leukocytosis (n=27, 84.38%). Escherichia coli was the most commonly isolated bacterium (63.63%). Both acute focal bacterial nephritis and acute multifocal bacterial nephritis were observed in 46.87% (n=15) and 53.13% (n=17) of the patients, respectively. Imaging studies were required for all diagnoses. Conclusion: Fever and leukocytosis are the main findings in acute bacterial nephritis. Imaging studies are necessary for making the diagnosis, given that acute pyelonephritis and acute bacterial nephritis cannot be clinically differentiated.

scholarly journals Urachal remnant carcinoma - a rare entity

2013 ◽  
Vol 17 (2) ◽  
pp. 63-64
Author(s):  
Vanesha Naidu ◽  
Narisha Maharaj ◽  
Ayesha Mitha ◽  
Jaynund Maharajh ◽  
Bhugwan Singh
Keyword(s):  
Clinical Course ◽  
Late Presentation ◽  
Imaging Features ◽  
Rare Entity ◽  
Primary Malignancy ◽  
Urachal Carcinoma ◽  
Urachal Remnant ◽  
Characteristic Imaging ◽  
Sister Mary Joseph’S Nodule ◽  
Initial Clinical Evaluation

Primary malignancy of the urachal remnant is a rare neoplasm that accounts for less than 0.01% of all adult cancers, with an estimated annual incidence of 1:5 million. The tumour carries a grave prognosis that attests to its highly aggressive nature. Owing to its extra-peritoneal location, the tumour runs a relatively silent clinical course until late presentation, when most patients display extensive local invasion and metastatic spread. In this report, we highlight a case of primary malignancy of the urachus that on initial clinical evaluation masqueraded as a Sister Mary Joseph’s nodule. Characteristic imaging features, however, proved decisive in establishing the diagnosis of a urachal carcinoma.

scholarly journals Clinical Course, Imaging Features, and Outcomes of COVID-19 in Kidney Transplant Recipients

2020 ◽  
Vol 78 (2) ◽  
pp. 281-286 ◽  
Author(s):  
Alireza Abrishami ◽  
Shiva Samavat ◽  
Behdad Behnam ◽  
Mehran Arab-Ahmadi ◽  
Mohsen Nafar ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Clinical Course ◽  
Imaging Features ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course

2016 ◽  
Vol 17 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Mohana Rao Patibandla ◽  
Thomas Ridder ◽  
Kathleen Dorris ◽  
Michelle R. Torok ◽  
Arthur K. Liu ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Clinical Course ◽  
Oncological Outcome ◽  
Tumor Location ◽  
Complete Resection ◽  
Low Grade ◽  
Imaging Features ◽  
Total Resection ◽  
Brainstem Death

OBJECT Ganglioglioma (GG) is commonly recognized as a low-grade tumor located in the temporal lobe, often presenting with seizures. Most are amenable to complete resection and are associated with excellent oncological outcome. The authors encountered several GGs in various locations, which seem to have a less favorable clinical course than GGs in the temporal lobe. METHODS The authors performed a single-center retrospective review of all children with a histological diagnosis of GG who were treated at Children’s Hospital Colorado between 1997 and 2013. Each tumor was categorized by 2 pediatric neuroradiologists as typical or atypical based on preoperative MRI appearance. Typical lesions were cortically based, within a single cerebral lobe, well-circumscribed, and solid or mixed solid/cystic. The treatment and clinical course of each patient was analyzed. RESULTS Thirty-seven children were identified, with a median age at presentation of 8.2 years and median follow-up of 38.0 months. Eighteen tumors (48.6%) were typical and 19 (51.4%) were atypical. All typical lesions presented with seizures, whereas no atypical lesions did so. Sixteen (88.9%) typical lesions were located in the temporal lobe. In the atypical group, tumor location was variable, including 11 (57.9%) in the brainstem. Death during follow-up was statistically more common in the atypical group (31.6% vs 0%, p = 0.02). Gross-total resection (GTR) was achieved for 15 of 16 typical tumors (93.8%), compared with 3 atypical tumors (15.8%, p < 0.0001). Presentation with seizure or non-brainstem location were each associated with survival (p = 0.02 and 0.004, respectively). The presence of mutation in BRAF exon 15 did not differ between the 2 groups. CONCLUSIONS Pediatric GG with typical imaging features is associated with excellent rates of GTR and overall survival. Atypical GG is commonly encountered, less amenable to GTR, and associated with a worse outcome. This may relate to anatomical or biological characteristics and merits further investigation.

Low-grade small round cell tumor of the cauda equina with EWSR1-WT1 fusion and indolent clinical course

2015 ◽  
Vol 46 (1) ◽  
pp. 153-158 ◽  
Author(s):  
Nasir Ud Din ◽  
Melike Pekmezci ◽  
Gohar Javed ◽  
Andrew E. Horvai ◽  
Zubair Ahmad ◽  
...  
Keyword(s):  
Clinical Course ◽  
Cauda Equina ◽  
Cell Tumor ◽  
Low Grade ◽  
Round Cell ◽  
Round Cell Tumor ◽  
Small Round Cell Tumor ◽  
Small Round Cell

Invasive aspergillosis of the skull base in an immunocompetent patient: a diagnostic challenge

2021 ◽  
Vol 14 (11) ◽  
pp. e245517
Author(s):  
Alexandra Borges ◽  
Lìgia Ferreira ◽  
Ricardo Pacheco ◽  
Isabel Fonseca
Keyword(s):  
Skull Base ◽  
Fungal Infections ◽  
Immunocompetent Patient ◽  
Imaging Features ◽  
Round Cell ◽  
Diagnostic Challenge ◽  
Small Round Cell ◽  
Tropical Climates ◽  
Small Round Cell Tumour ◽  
Immunocompetent Patients

We describe the case of a 32-year-old man from Cape Verde having headache and increasing visual loss. Clinical and radiological investigations disclosed a massive destructive lesion involving the anterior and central skull base, orbit and nasoethmoid region initially interpreted as a malignant small round cell tumour. Surgical biopsies were negative for neoplasm, showing an intense inflammatory infiltrate together with fungus, later characterised as Aspergillus flavus spp. The patient was immunocompetent with no evidence of congenital or acquired immunodeficiencies. Invasive fungal infections in immunocompetent patients are rare and can be a diagnostic challenge. The best diagnostic clues include the patient’s origin from tropical climates, imaging features and the identification of fungal hyphae on pathology specimens. Although a devastating disease in immunocompromised patients, craniocerebral aspergillosis in immunocompetent patients carries a better prognosis. Available literature supports the combined used of ‘conservative’ surgical resection and antifungal therapy as the best treatment option.

Multiple evanescent white dot syndrome: clinical course and factors influencing visual acuity recovery

2020 ◽  
pp. bjophthalmol-2020-317357
Author(s):  
Francesca Bosello ◽  
Mark Westcott ◽  
Giuseppe Casalino ◽  
Georgios Agorogiannis ◽  
Rocco Micciolo ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Near Infrared ◽  
Clinical Course ◽  
Fundus Autofluorescence ◽  
Young Age ◽  
Imaging Features ◽  
Near Infrared Reflectance ◽  
White Dot Syndrome ◽  
Group 2

ObjectiveTo report the demographics and the clinical course of patients with multiple evanescent white dot syndrome (MEWDS) and to investigate for those factors which influence visual acuity (VA) recovery.MethodsThis is a retrospective single-centre observational study. Electronic medical records and retinal imaging of patients with a diagnosis of MEWDS with a minimum follow-up of 3 months were reviewed. Patients were categorised into three groups according to the VA at presentation and at the last visit: group 1 >0.48 logarithm of the minimum angle of resolution (LogMAR), group 2 ≤0.48 and ≥0.18 LogMAR and group 3 <0.18 LogMAR. All patients had non-invasive multimodal imaging including optical coherence tomography, near-infrared reflectance imaging and blue fundus autofluorescence at presentation and during follow-up.ResultsA total of 51 eyes from 51 patients (41 women, mean age 29.8±7.8 years) were included. Significantly more patients presented in the autumn (X2=8.69, p=0.034). The percentage of eyes recovering vision to 0.0 LogMAR or better was 80.3% (41/51). Worse presenting vision and young age at presentation were independent significant predictive variables for poorer final VA (p=0.002 and p=0.02, respectively). No imaging features were significantly predictive of complete versus incomplete recovery, but disc hyperfluorescence on fluorescein angiography was more common in those with incomplete recovery.ConclusionsAlthough the majority of cases have a benign prognosis, the clinical spectrum of MEWDS includes incomplete visual recovery. In our series, poor presenting VA and young age were associated with poor VA outcome. Further study is warranted to confirm these findings.

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