scholarly journals Assessment of iodine uptake by pancreatic cancer following chemotherapy using dual-energy CT

2018 ◽  
Vol 43 (2) ◽  
pp. 445-456 ◽  
Author(s):  
Satomi Kawamoto ◽  
Matthew. K. Fuld ◽  
Daniel Laheru ◽  
Peng Huang ◽  
Elliot K. Fishman
Keyword(s):  
Pancreatic Cancer ◽  
Dual Energy ◽  
Iodine Uptake ◽  
Dual Energy Ct

Liver fibrosis assessment with multiphasic dual-energy CT: diagnostic performance of iodine uptake parameters

2021 ◽  
Author(s):  
Yasunori Nagayama ◽  
Yuki Kato ◽  
Taihei Inoue ◽  
Takeshi Nakaura ◽  
Seitaro Oda ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Diagnostic Performance ◽  
Dual Energy ◽  
Iodine Uptake ◽  
Dual Energy Ct

scholarly journals AI Lung Segmentation and Perfusion Analysis of Dual-Energy CT Can Help to Distinguish COVID-19 Infiltrates from Visually Similar Immunotherapy-Related Pneumonitis Findings and Can Optimize Radiological Workflows

Tomography ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 22-32
Author(s):  
Andreas S. Brendlin ◽  
Markus Mader ◽  
Sebastian Faby ◽  
Bernhard Schmidt ◽  
Ahmed E. Othman ◽  
...  
Keyword(s):  
Decision Making ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Intraclass Correlation ◽  
Iodine Concentration ◽  
Dual Energy ◽  
Iodine Uptake ◽  
Dual Energy Ct ◽  
Multinomial Regression ◽  
Potential Impact

(1) To explore the potential impact of an AI dual-energy CT (DECT) prototype on decision making and workflows by investigating its capabilities to differentiate COVID-19 from immunotherapy-related pneumonitis. (2) Methods: From 3 April 2020 to 12 February 2021, DECT from biometrically matching patients with COVID-19, pneumonitis, and inconspicuous findings were selected from our clinical routine. Three blinded readers independently scored each pulmonary lobe analogous to CO-RADS. Inter-rater agreement was determined with an intraclass correlation coefficient (ICC). Averaged perfusion metrics per lobe (iodine uptake in mg, volume without vessels in ml, iodine concentration in mg/mL) were extracted using manual segmentation and an AI DECT prototype. A generalized linear mixed model was used to investigate metric validity and potential distinctions at equal CO-RADS scores. Multinomial regression measured the contribution “Reader”, “CO-RADS score”, and “perfusion metrics” to diagnosis. The time to diagnosis was measured for manual vs. AI segmentation. (3) Results: We included 105 patients (62 ± 13 years, mean BMI 27 ± 2). There were no significant differences between manually and AI-extracted perfusion metrics (p = 0.999). Regardless of the CO-RADS score, iodine uptake and concentration per lobe were significantly higher in COVID-19 than in pneumonitis (p < 0.001). In regression, iodine uptake had a greater contribution to diagnosis than CO-RADS scoring (Odds Ratio (OR) = 1.82 [95%CI 1.10–2.99] vs. OR = 0.20 [95%CI 0.14–0.29]). The AI prototype extracted the relevant perfusion metrics significantly faster than radiologists (10 ± 1 vs. 15 ± 2 min, p < 0.001). (4) Conclusions: The investigated AI prototype positively impacts decision making and workflows by extracting perfusion metrics that differentiate COVID-19 from visually similar pneumonitis significantly faster than radiologists.

scholarly journals Correction to: Liver fibrosis assessment with multiphasic dual-energy CT: diagnostic performance of iodine uptake parameters

2021 ◽  
Author(s):  
Yasunori Nagayama ◽  
Yuki Kato ◽  
Taihei Inoue ◽  
Takeshi Nakaura ◽  
Seitaro Oda ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Diagnostic Performance ◽  
Dual Energy ◽  
Iodine Uptake ◽  
Dual Energy Ct

scholarly journals Correlation of iodine uptake and perfusion parameters between dual-energy CT imaging and first-pass dual-input perfusion CT in lung cancer

Medicine ◽  
2017 ◽  
Vol 96 (28) ◽  
pp. e7479 ◽  
Author(s):  
Xiaoliang Chen ◽  
Yanyan Xu ◽  
Jianghui Duan ◽  
Chuandong Li ◽  
Hongliang Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dual Energy ◽  
Ct Imaging ◽  
Perfusion Ct ◽  
Iodine Uptake ◽  
Dual Energy Ct ◽  
First Pass

Metastatic and non-metastatic lymph nodes: quantification and different distribution of iodine uptake assessed by dual-energy CT

2017 ◽  
Vol 28 (2) ◽  
pp. 760-769 ◽  
Author(s):  
Stefania Rizzo ◽  
Davide Radice ◽  
Marco Femia ◽  
Paolo De Marco ◽  
Daniela Origgi ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Dual Energy ◽  
Iodine Uptake ◽  
Dual Energy Ct ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252478
Author(s):  
Florian Poschenrieder ◽  
Stefanie Meiler ◽  
Matthias Lubnow ◽  
Florian Zeman ◽  
Janine Rennert ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Surrogate Marker ◽  
Dual Energy ◽  
Ground Glass ◽  
Iodine Uptake ◽  
Normal Lung ◽  
Dual Energy Ct ◽  
Pulmonary Perfusion ◽  
Subjective Analysis ◽  
Wide Range

Background Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion mismatch. Dual-energy CT (DECT) can depict pulmonary perfusion by regional assessment of iodine uptake. Objective The purpose of this study was the analysis of pulmonary perfusion using dual-energy CT in a cohort of 27 consecutive patients with severe COVID-19 pneumonia. Method We retrospectively analyzed pulmonary perfusion with DECT in 27 consecutive patients (mean age 57 years, range 21–73; 19 men and 8 women) with severe COVID-19 pneumonia. Iodine uptake (IU) in regions-of-interest placed into normally aerated lung, ground-glass opacifications (GGO) and consolidations was measured using a dedicated postprocessing software. Vessel enlargement (VE) within opacifications and presence of pulmonary embolism (PE) was assessed by subjective analysis. Linear mixed models were used for statistical analyses. Results Compared to normally aerated lung 106/151 (70.2%) opacifications without upstream PE demonstrated an increased IU, 9/151 (6.0%) an equal IU and 36/151 (23.8%) a decreased IU. The estimated mean iodine uptake (EMIU) in opacifications without upstream PE (GGO 1.77 mg/mL; 95%-CI: 1.52–2.02; p = 0.011, consolidations 1.82 mg/mL; 95%-CI: 1.56–2.08, p = 0.006) was significantly higher compared to normal lung (1.22 mg/mL; 95%-CI: 0.95–1.49). In case of upstream PE, EMIU of opacifications (combined GGO and consolidations) was significantly decreased compared to normal lung (0.52 mg/mL; 95%-CI: -0.07–1.12; p = 0.043). The presence of VE in opacifications correlated significantly with iodine uptake (p<0.001). Conclusions DECT revealed the opacifications in a subset of patients with severe COVID-19 pneumonia to be perfused non-uniformly with some being hypo- and others being hyperperfused. Mean iodine uptake in opacifications (both ground-glass and consolidation) was higher compared to normally aerated lung except for areas with upstream pulmonary embolism. Vessel enlargement correlated with iodine uptake: In summary, in a cohort of 27 consecutive patients with severe COVID-19 pneumonia, dual-energy CT demonstrated a wide range of iodine uptake in pulmonary ground-glass opacifications and consolidations as a surrogate marker for hypo- and hyperperfusion compared to normally aerated lung. Applying DECT to determine which pathophysiology is predominant might help to tailor therapy to the individual patient´s needs.

Dual-Energy CT Imaging May Play Role in Gout Diagnosis

2009 ◽  
Vol 39 (2) ◽  
pp. 21
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Dual Energy ◽  
Ct Imaging ◽  
Dual Energy Ct
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