Immunotherapy with dendritic cells pulsed with tumor-derived gp96 against murine lung cancer is effective through immune response of CD8+ cytotoxic T lymphocytes and natural killer cells

2007 ◽  
Vol 57 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Naofumi Shinagawa ◽  
Koichi Yamazaki ◽  
Yasuaki Tamura ◽  
Akihito Imai ◽  
Eiki Kikuchi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune Response ◽  
Dendritic Cells ◽  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Killer Cells ◽  
Murine Lung

scholarly journals Metabolic Remodeling in Glioma Immune Microenvironment: Intercellular Interactions Distinct From Peripheral Tumors

2021 ◽  
Vol 9 ◽  
Author(s):  
Runze Qiu ◽  
Yue Zhong ◽  
Qingquan Li ◽  
Yingbin Li ◽  
Hongwei Fan
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Tumor Microenvironment ◽  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Regulatory T Cells ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Glioma Cells ◽  
Killer Cells

During metabolic reprogramming, glioma cells and their initiating cells efficiently utilized carbohydrates, lipids and amino acids in the hypoxic lesions, which not only ensured sufficient energy for rapid growth and improved the migration to normal brain tissues, but also altered the role of immune cells in tumor microenvironment. Glioma cells secreted interferential metabolites or depriving nutrients to injure the tumor recognition, phagocytosis and lysis of glioma-associated microglia/macrophages (GAMs), cytotoxic T lymphocytes, natural killer cells and dendritic cells, promoted the expansion and infiltration of immunosuppressive regulatory T cells and myeloid-derived suppressor cells, and conferred immune silencing phenotypes on GAMs and dendritic cells. The overexpressed metabolic enzymes also increased the secretion of chemokines to attract neutrophils, regulatory T cells, GAMs, and dendritic cells, while weakening the recruitment of cytotoxic T lymphocytes and natural killer cells, which activated anti-inflammatory and tolerant mechanisms and hindered anti-tumor responses. Therefore, brain-targeted metabolic therapy may improve glioma immunity. This review will clarify the metabolic properties of glioma cells and their interactions with tumor microenvironment immunity, and discuss the application strategies of metabolic therapy in glioma immune silence and escape.

Induction of myeloma-specific cytotoxic T lymphocytes responses by natural killer cells stimulated-dendritic cells in patients with multiple myeloma

2011 ◽  
Vol 35 (9) ◽  
pp. 1241-1247 ◽  
Author(s):  
Thanh-Nhan Nguyen-Pham ◽  
Chang-Min Im ◽  
Truc-Anh Thi Nguyen ◽  
Mi-Seon Lim ◽  
Cheol Yi Hong ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Dendritic Cells ◽  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Killer Cells

Cytotoxic T lymphocytes and natural killer cells

2013 ◽  
pp. 215-227
Author(s):  
Stephen L. Nutt ◽  
Sebastian Carotta ◽  
Axel Kallies ◽  
Gabrielle T. Belz
Keyword(s):  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Killer Cells

Molecular Basis of Lymphocyte-Mediated Destruction of Traget Cells

Physiology ◽  
1988 ◽  
Vol 3 (5) ◽  
pp. 211-216
Author(s):  
JD-E Young ◽  
ZA Cohn
Keyword(s):  
Natural Killer Cells ◽  
T Lymphocytes ◽  
Natural Killer ◽  
Cytotoxic T Lymphocytes ◽  
Immune Cells ◽  
Molecular Basis ◽  
Target Cells ◽  
Killer Cells

Subsets of lymphocytes, known as cytotoxic T lymphocytes or natural killer cells, are potent killers of target cells. These immune cells have large granules in their cytoplasm containing cytotoxic peptides and other factors. Several of these molecules have been isolated and their functions elucidated.

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