Preparation and characterization of pH sensitive poly(vinyl alcohol)/sodium carboxymethyl cellulose IPN microspheres for in vitro release studies of an anti-cancer drug

2011 ◽  
Vol 68 (7) ◽  
pp. 1905-1919 ◽  
Author(s):  
K. Madhusudana Rao ◽  
B. Mallikarjuna ◽  
K. S. V. Krishna Rao ◽  
M. N. Prabhakar ◽  
K. Chowdoji Rao ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Carboxymethyl Cellulose ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Poly Vinyl Alcohol ◽  
Release Studies ◽  
Anti Cancer ◽  
Vitro Release

scholarly journals FORMULATION AND EVALUATION OF A CHITOSAN-PVA-GELLAN INSULIN IMPLANT

2017 ◽  
Vol 9 (3) ◽  
pp. 37
Author(s):  
Satish C. S.
Keyword(s):  
Diffusion Coefficient ◽  
Insulin Release ◽  
In Vitro Release ◽  
Poly Vinyl Alcohol ◽  
Content Uniformity ◽  
Release Studies ◽  
Solution Casting Method ◽  
Implant System ◽  
Vitro Release

Objective: The purpose of this study was to ascertain the applicability of degradable materials for fabrication of an insulin release system.Methods: Insulin implants were prepared by using poly (vinyl alcohol) (PVA), gellan and chitosan by solution casting method. The prepared implants were evaluated for swellability, content uniformity, potency and purity of insulin in implants, scanning electron microscopy studies, in vitro release studies, in vitro degradation studies using lysozyme, stability studies and circular dichroism spectroscopy.Results: The swelling degree of the implants was found to be in the range of 1.07-1.56. The diffusion coefficient of water through the implant was found to depend on the calcium chloride (CaCl2) concentration. The diffusion coefficient of insulin through the chitosan-PVA-gellan in the early stages was found to be in the range of 1.99´10-5 cm2/sec to 5.24´10-5 cm2/sec and at later stages in the range of 6.9´10-6 cm2/sec to 1.10´10-5 cm2/sec. The weight of the implants was 48±0.58 mg. The insulin content in the implants was 9.86±0.10 mg. The potency of insulin extracted from the implants was 27.11±0.75 U/mg or 95.12±2.61 % of the control insulin. The in vitro release studies showed that insulin was released completely in a period of 13-19 d depending on the composition of the implant. The increase in CaCl2 retarded the rate of insulin release whereas the increase in PVA content leads to the rapid release of insulin. The device was found to undergo significant weight loss due to enzyme mediated degradation.Conclusion: These studies provide validity for the potential utility of chitosan-PVA-gellan implant systems for the delivery of insulin. The studies also demonstrate that insulin maintained its integrity within the implant system. Implants showed the complete release of insulin in 19 d and the release of insulin from the implants depended on the amount of CaCl2.

Preparation and Characterization of Sodium Alginate-Based Hydrogels and Their In Vitro Release Studies

2013 ◽  
Vol 32 (2) ◽  
pp. n/a-n/a ◽  
Author(s):  
Bandla Manjula ◽  
Kokkarachedu Varaprasad ◽  
Rotimi Sadiku ◽  
K. Mohana Raju
Keyword(s):  
Sodium Alginate ◽  
In Vitro Release ◽  
Release Studies ◽  
Vitro Release

Preparation and Characterization of Electrospun Poly(vinyl Alcohol)/Silk Fibroin Nanofibers as a Potential Drug Delivery System

2013 ◽  
Vol 709 ◽  
pp. 215-220 ◽  
Author(s):  
Dou Dou Zhang ◽  
Li Xing Dai
Keyword(s):  
Silk Fibroin ◽  
Release Rate ◽  
Vinyl Alcohol ◽  
In Vitro Release ◽  
Poly Vinyl Alcohol ◽  
Silk Fibroin Nanofibers ◽  
Nanofiber Mats ◽  
Drug Free

A series of poly(vinyl alcohol)/silk fibroin nanofibers loaded with 10 wt.% vanillin were successfully prepared from aqueous solutions via electrospinning. The morphology, weight loss and swelling ability of the nanofibers were characterized. The controlled release characteristics of vanillin in the nanofiber mats were evaluated by in vitro release test. Vanillin-loaded nanofibers had smooth surfaces like drug-free nanofibers, and showed thinner diameter than the latter. The release rate of vanillin in the nanofiber mats decreased with the increment of silk fibroin content, so by regulating the content the drug release could be controlled. Moreover, after treated with ethanol the nanofiber mats showed better stability against disintegration in water and sustained release rate of vanillin than untreated mats.

Formulation and Characterization of Sodium Alginate g-Hydroxy Ethylacrylate Bio-Degradable Polymeric Beads: In Vitro Release Studies

2012 ◽  
Vol 20 (2) ◽  
pp. 344-352 ◽  
Author(s):  
Chavidi Venkata Prasad ◽  
Bala Yerri Swamy ◽  
Chanda Lakshmi Narayana Reddy ◽  
Kokkarachedu Vara Prasad ◽  
Posa Sudhakara ◽  
...  
Keyword(s):  
Sodium Alginate ◽  
In Vitro Release ◽  
Release Studies ◽  
Polymeric Beads ◽  
Vitro Release

scholarly journals Synthesis and characterization of new macromolecule systems for colon-specific drug delivery

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
M. Galehassadi ◽  
M. Mahkam ◽  
F. Hosseinzadeh
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Network Polymers ◽  
Release Studies ◽  
Silyl Groups ◽  
Silyl Derivatives ◽  
Derivatives Of ◽  
Vitro Release

AbstractNetwork polymers containing silyl groups were synthesized. Silyl derivatives of 2-hydroxyethylmethacrylate (HEMA), and methacrylic acid (MAA) were copolymerized with 1,2-bis(vinylphenyl)ethane (BVPE) and divinylbenzene (DVB) as cross-linking agents by radical polymerization using α,α′-azobis (isobutyronitrile) (AIBN) as initiator to produce network polymers. Then mesalasine (MZ) were loaded to these network polymers, and amount of drug entrapped was determined. In vitro release studies showed that drug delivery property was modified and showed considerable difference in swelling at pH 1 and 7.4. Incorporation of silyl groups in new macromolecule system modified network polymers for drug delivery. Monomers and polymers were characterized by spectroscopic methods.

Sign in / Sign up

Export Citation Format

Share Document