Chemical modification of alginate with tosylmethyl isocyanide, propionaldehyde and octylamine via the Ugi reaction for hydrophobic drug delivery

2021 ◽  
Author(s):  
Zhaowen Liu ◽  
Xiuqiong Chen ◽  
Yanshi Wen ◽  
Chaoling Bao ◽  
Chunyang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Ugi Reaction ◽  
Hydrophobic Drug ◽  
Tosylmethyl Isocyanide

Magnetic Nanoparticles Grafted with Cyclodextrin for Hydrophobic Drug Delivery

2007 ◽  
Vol 19 (25) ◽  
pp. 6345-6349 ◽  
Author(s):  
Shashwat S. Banerjee ◽  
Dong-Hwang Chen
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Hydrophobic Drug

Nanoparticulate Drug Delivery Systems: An update

2021 ◽  
pp. 312-316
Author(s):  
Pandey Swarnima ◽  
Sushant Kumar
Keyword(s):  
Drug Delivery ◽  
Carrying Capacity ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
Classification Methods ◽  
Hydrophobic Drug ◽  
Drug Molecules ◽  
Conventional Drug ◽  
Novel Drug

The paper is aimed to provide a comprehensive review on nanoparticles, methods of preparation, applications in drug delivery. In recent years, there has been an exponential interest within the development of novel drug delivery systems using nanoparticles. Nanoparticles offers significant advantages over the conventional drug delivery in terms of high stability, high specificity, high drug carrying capacity, ability for controlled release, possibility to use in several route of administration and therefore the capability to deliver both hydrophilic and hydrophobic drug molecules. This review focuses on classification, methods of preparation, characterization, application, advantages of nanoparticles and health perspectives.

scholarly journals CHEMICAL MODIFICATION, CHARACTERIZATION AND EVALUATION OF MUCOADHESIVE POTENTIALITY OF ASSAM BORA RICE STARCH

2017 ◽  
Vol 9 (9) ◽  
pp. 132 ◽  
Author(s):  
Abdul Baquee Ahmed ◽  
Iman Bhaduri
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Sustained Release ◽  
Chemical Modification ◽  
Ex Vivo ◽  
Rice Starch ◽  
Modified Starch ◽  
Native Starch ◽  
Ft Ir

Objective: The objective of the present study was to chemical modification, characterization and evaluation of mucoadhesive potentiality of Assam bora rice starch as potential excipients in the sustained release drug delivery system. Methods: The starch was isolated from Assam bora rice and esterified using thioglycolic acid and characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and Nuclear magnetic resonance (NMR). The 10% w/v gel formulation based on modified bora rice starch loaded with irinotecan (0.6%) was prepared and evaluated for various rheological properties, ex-vivo mucoadhesion using goat intestine and in vitro drug release study in phosphate buffer pH 6.8.Results: The chemical modification was confirmed by FT-IR and NMR studies with the presence of the peak at 2626.74 cm-1 and a singlet at 2.51 respectively due to–SH group. Ex-vivo mucoadhesion studies showed 6.6 fold increases in mucoadhesion of the modified starch with compared to native starch (46.3±6.79g for native starch; 308.7±95.31g for modified starch). In vitro study showed 89.12±0.84 % of drug release after 6 h in phosphate buffer pH 6.8 and the release kinetics followed Non-Fickian diffusion.Conclusion: The modified Assam bora rice starch enhanced a mucoadhesive property of the native starch and thus, can be explored in future as a potential excipient for the sustained release mucoadhesive drug delivery system.

scholarly journals A Micellar-Hydrogel Nanogrid from a UV Crosslinked Inulin Derivative for the Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 97 ◽  
Author(s):  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sara Perteghella ◽  
Cinzia Di Franco ◽  
Maria Torre ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Beclomethasone Dipropionate ◽  
Polymeric Micelles ◽  
Hydrophobic Drugs ◽  
Hydrophobic Drug ◽  
Hydrophilic Drugs ◽  
Uv Crosslinking ◽  
Colon Drug Delivery ◽  
Materials Used ◽  
Simultaneous Delivery

Hydrogels are among the most common materials used in drug delivery, as polymeric micelles are too. They, preferentially, load hydrophilic and hydrophobic drugs, respectively. In this paper, we thought to combine the favorable behaviors of both hydrogels and polymeric micelles with the specific aim of delivering hydrophilic and hydrophobic drugs for dual delivery in combination therapy, in particular for colon drug delivery. Thus, we developed a hydrogel by UV crosslinking of a methacrylated (MA) amphiphilic derivative from inulin (INU) (as known INU is specifically degraded into the colon) and vitamin E (VITE), called INVITEMA. The methacrylated micelles were physicochemically characterized and subjected to UV irradiation to form what we called the “nanogrids”. The INVITEMA nanogrids were characterized by DSC, SEM, TEM, water uptake and beclomethasone dipropionate (BDP) release. In particular, the release of the hydrophobic drug was specifically assessed to verify that it can spread along the hydrophilic portions and, therefore, effectively released. These systems can open new pharmaceutical applications for known hydrogels or micelle systems, considering that in literature only few examples are present.

A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel

2008 ◽  
Vol 359 (1-2) ◽  
pp. 228-233 ◽  
Author(s):  
MaLing Gou ◽  
XingYi Li ◽  
Mei Dai ◽  
ChangYang Gong ◽  
XianHuo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Biodegradable Nanoparticles

Schiff-base based hydrogels as degradable platforms for hydrophobic drug delivery

2017 ◽  
Vol 90 ◽  
pp. 13-24 ◽  
Author(s):  
Esmat Jalalvandi ◽  
Lyall R. Hanton ◽  
Stephen C. Moratti
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Hydrophobic Drug

scholarly journals Synthesis and characterization of perfluoro-tert-butyl semifluorinated amphiphilic polymers and their potential application in hydrophobic drug delivery

2014 ◽  
Vol 5 (22) ◽  
pp. 6461-6471 ◽  
Author(s):  
Sarah Decato ◽  
Troy Bemis ◽  
Eric Madsen ◽  
Sandro Mecozzi
Keyword(s):  
Drug Delivery ◽  
Potential Application ◽  
Amphiphilic Polymers ◽  
Synthesis And Characterization ◽  
Hydrophobic Drug ◽  
Tert Butyl ◽  
Theranostic Applications ◽  
Polymer Surfactants

Semifluorinated polymer surfactants containing one, two, or three perfluoro-tert-butyl groups were synthesized and fully characterized. Theranostic applications are discussed.

Intravenous Hydrophobic Drug Delivery: A Porous Particle Formulation of Paclitaxel (AI-850)

2005 ◽  
Vol 22 (3) ◽  
pp. 347-355 ◽  
Author(s):  
Julie A. Straub ◽  
Donald E. Chickering ◽  
Jonathan C. Lovely ◽  
Huimin Zhang ◽  
Bhavdeep Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Particle ◽  
Hydrophobic Drug

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

2018 ◽  
Vol 47 ◽  
pp. 62-66 ◽  
Author(s):  
Yuko Okamoto ◽  
Kazuaki Taguchi ◽  
Mina Sakuragi ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Hydrophobic Drug ◽  
Delivery Efficiency
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