scholarly journals Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

2021 ◽  
Vol 127 (4) ◽  
Author(s):  
S. Skruszewicz ◽  
S. Fuchs ◽  
J. J. Abel ◽  
J. Nathanael ◽  
J. Reinhard ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Near Infrared ◽  
Extreme Ultraviolet ◽  
Infrared Light ◽  
Imaging Method ◽  
Optical Coherence ◽  
Axial Resolution ◽  
Cross Sectional ◽  
X Ray ◽  
Broad Bandwidth

AbstractWe present an overview of recent results on optical coherence tomography with the use of extreme ultraviolet and soft X-ray radiation (XCT). XCT is a cross-sectional imaging method that has emerged as a derivative of optical coherence tomography (OCT). In contrast to OCT, which typically uses near-infrared light, XCT utilizes broad bandwidth extreme ultraviolet (XUV) and soft X-ray (SXR) radiation (Fuchs et al in Sci Rep 6:20658, 2016). As in OCT, XCT’s axial resolution only scales with the coherence length of the light source. Thus, an axial resolution down to the nanometer range can be achieved. This is an improvement of up to three orders of magnitude in comparison to OCT. XCT measures the reflected spectrum in a common-path interferometric setup to retrieve the axial structure of nanometer-sized samples. The technique has been demonstrated with broad bandwidth XUV/SXR radiation from synchrotron facilities and recently with compact laboratory-based laser-driven sources. Axial resolutions down to 2.2 nm have been achieved experimentally. XCT has potential applications in three-dimensional imaging of silicon-based semiconductors, lithography masks, and layered structures like XUV mirrors and solar cells.

scholarly journals Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Silvio Fuchs ◽  
Christian Rödel ◽  
Alexander Blinne ◽  
Ulf Zastrau ◽  
Martin Wünsche ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Nanometer Resolution ◽  
X Ray ◽  
Broad Bandwidth

Abstract 3322: Chronic Vascular Responses To Sirolimus-eluting Stent Compared With Bare-metal Stent In Diabetic Patients: Evaluated By Optical Coherence Tomography.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Takashi Kubo ◽  
Toshio Imanishi ◽  
Hiroki Matsumoto ◽  
Manabu Kashiwagi ◽  
Hiroto Tsujioka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Neointimal Hyperplasia ◽  
Bare Metal Stent ◽  
Diabetic Patients ◽  
Imaging Method ◽  
Bare Metal ◽  
Optical Coherence ◽  
Metal Stent ◽  
Cross Sectional ◽  
Sirolimus Eluting Stent

OBJECTIVE: An optical coherence tomography (OCT) study was performed to compre the vascular response to sirolimus-eluting stent (SES) with bare-metal stent (BMS) in patients with diabetic mellitus (DM). BACKGROUND: Despite advances in the medical treatment and revascularization procedures, coronary artery disease remains a leading cause of morbidity and mortality in patients with DM. Few retrospective subgroup analyses of pivotal clinical trials have suggested that SES may be effective for reduction of restenosis in diabetic patients. OCT is a new intravascular imaging method with a high resolution of approximately 10 micrometer and allows us to evaluate instent neointimal hyperplasia (NIH) in vivo. METHODS and RESULTS: Serial OCT analyses were performed in 60 lesions (SES in DM patients=19; SES in non-DM patients=14; BMS in DM patients=10; BMS in non-DM patients=17) at 9-month follow-up. A total of 6920 stent struts were visualized by OCT and NIH thickness inside each strut and incidence of exposed stnet struts were evaluated in cross-sectional image. The NIH thickness was significantly different among 4 groups (97 +/− 100 vs. 43 +/− 61 vs. 425 +/− 206 vs. 209 +/− 138 micrometer, respectively). The NIH thickness of SES in DM was significantly thicker than that of SES in non-DM (p<0.001), although it was significantly thinner than that of BMS in DM (p<0.001) or BMS in non-DM (p<0.001). All struts of BMS were covered by neointima, but 14% of struts of SES were exposed. The incidence of exposed struts and exposed struts with inadequate apposition in DES were significantly lower in DM compared with those in non-DM (5% vs. 34%, p<0.0001; 2% vs. 5%, p <0.001, respectively). Moreover, the frequency of DES with partially exposed strut was significantly lower in DM than non-DM (32% vs. 71%, p<0.027). CONCLUSION: The present OCT study revealed that DES inhibited the NIH effectively with low incidence of exposed stent strut in DM patients at 9-month after implantation.

scholarly journals 3D imaging of proximal caries in posterior teeth using optical coherence tomography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yasushi Shimada ◽  
Michael F. Burrow ◽  
Kazuyuki Araki ◽  
Yuan Zhou ◽  
Keiichi Hosaka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Accuracy ◽  
3D Imaging ◽  
Characteristic Curve ◽  
Weighted Kappa ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Posterior Teeth ◽  
Proximal Caries ◽  
X Ray

Abstract Optical coherence tomography (OCT) can create cross-sectional images of tooth without X-ray exposure. This study aimed to investigate the diagnostic accuracy of 3D imaging of OCT for proximal caries in posterior teeth. Thirty-six human molar teeth with 51 proximal surfaces visibly 6 intact, 16 slightly demineralized, and 29 distinct carious changes were mounted to take digital radiographs and 3D OCT images. The sensitivity, specificity and area under the receiver operating characteristic curve (AUC) for the diagnosis of enamel caries and dentin caries were calculated to quantify the diagnostic ability of 3D OCT in comparison with digital radiography. Diagnostic accuracy was evaluated by the agreement with histology using weighted Kappa. OCT showed significantly higher sensitivity, AUC and Kappa values than radiography. OCT can be a safer option for the diagnosis of proximal caries in posterior teeth that can be applied to the patients without X-ray exposure.

scholarly journals Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

2019 ◽  
Vol 2 (4) ◽  
pp. 109-118
Author(s):  
H Silver Frederick ◽  
◽  
G Shah Ruchit ◽  
Kelkar Nikita ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Near Infrared ◽  
Normal Skin ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Infrared Light ◽  
Optical Coherence ◽  
Congenital Nevus

We have used vibrational optical coherence tomography (VOCT) to image and measure the mechanical properties of normal skin and skin lesions. It is observed that in a congenital nevus and normal skin, the cellular epidermis is qualitatively not as bright as in skin lesions including basal cell carcinoma, actinic keratosis and a melanocytic nevus. Melanin and cytochrome c oxidase are reported to attenuate the reflection of near-infrared light at a wavelength of 810 nm and therefore may explain the reduced reflection of light in a congenital nevus and normal skin under conditions where cytochrome c oxidase levels would be expected to be high. Our results suggest that the melanin and cytochrome c oxidase levels found in congenital nevus and skin lesions may influence the observed pixel density observed in OCT images. For this reason, a correction for the content of these components in the skin must be considered before quantitative pixel measurements can be correctly interpreted. Additional measurements of pixel density along with the moduli of cellular and collagenous components in skin and skin lesions are needed to further interpret the significance of “virtual biopsies” made using VOCT.

scholarly journals Cooperative Three-View Imaging Optical Coherence Tomography for Intraoperative Vascular Evaluation

2018 ◽  
Vol 8 (9) ◽  
pp. 1551
Author(s):  
Shizhao Peng ◽  
Yuanzhen Jiang ◽  
Kailin Zhang ◽  
Chuanchao Wu ◽  
Danni Ai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Mechanical Design ◽  
Optical Design ◽  
Flow Speed ◽  
Imaging Method ◽  
Outer Diameter ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Imaging Optical Coherence Tomography ◽  
Oct Imaging

Real-time intraoperative optical coherence tomography (OCT) imaging of blood vessels after anastomosis operation can provide important information the vessel, such as patency, flow speed, and thrombosis morphology. Due to the strong scattering and absorption effect of blood, normal OCT imaging suffers from the problem of incomplete cross-sectional view of the vessel under investigation when the diameter is large. In this work, we present a novel cooperative three-view imaging spectral domain optical coherence tomography system for intraoperative exposed vascular imaging. Two more side views (left view and right view) were realized through a customized sample arm optical design and corresponding mechanical design and fabrication, which could generate cross-sectional images from three circumferential view directions to achieve a larger synthetic field of view (FOV). For each view, the imaging depth was 6.7 mm (in air) and the lateral scanning range was designed to be 3 mm. Therefore, a shared synthetic rectangle FOV of 3 mm × 3 mm was achieved through cooperative three view scanning. This multi-view imaging method can meet the circumferential imaging demands of vessels with an outer diameter less than 3 mm. Both phantom tube and rat vessel imaging confirmed the increased system FOV performance. We believe the intraoperative application of this cooperative three-imaging optical coherence tomography for objective vascular anastomosis evaluation can benefit patient outcomes in the future.

Optical Biopsy of Lymph Node Morphology using Optical Coherence Tomography

2005 ◽  
Vol 4 (5) ◽  
pp. 539-547 ◽  
Author(s):  
Wei Luo ◽  
Freddy T. Nguyen ◽  
Adam M. Zysk ◽  
Tyler S. Ralston ◽  
John Brockenbrough ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Lymph Node ◽  
High Resolution ◽  
Breast Imaging ◽  
Optical Tomography ◽  
Screening Method ◽  
Optical Biopsy ◽  
Infrared Light ◽  
Optical Coherence ◽  
Cross Sectional

Optical diagnostic imaging techniques are increasingly being used in the clinical environment, allowing for improved screening and diagnosis while minimizing the number of invasive procedures. Diffuse optical tomography, for example, is capable of whole-breast imaging and is being developed as an alternative to traditional X-ray mammography. While this may eventually be a very effective screening method, other optical techniques are better suited for imaging on the cellular and molecular scale. Optical Coherence Tomography (OCT), for instance, is capable of high-resolution cross-sectional imaging of tissue morphology. In a manner analogous to ultrasound imaging except using optics, pulses of near-infrared light are sent into the tissue while coherence-gated reflections are measured interferometrically to form a cross-sectional image of tissue. In this paper we apply OCT techniques for the high-resolution three-dimensional visualization of lymph node morphology. We present the first reported OCT images showing detailed morphological structure and corresponding histological features of lymph nodes from a carcinogen-induced rat mammary tumor model, as well as from a human lymph node containing late stage metastatic disease. The results illustrate the potential for OCT to visualize detailed lymph node structures on the scale of micrometastases and the potential for the detection of metastatic nodal disease intraoperatively.

scholarly journals Optical Coherence Tomography for Examination of Parchment Degradation

2006 ◽  
Vol 2006 ◽  
pp. 1-6 ◽  
Author(s):  
Michalina Góra ◽  
Michael Pircher ◽  
Erich Götzinger ◽  
Tomasz Bajraszewski ◽  
Matija Strlic ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Axis ◽  
Incident Light ◽  
Infrared Light ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Central Wavelength ◽  
Non Invasive ◽  
Spectral Oct ◽  
Iron Gall

A novel application of Optical Coherence Tomography utilizing infrared light of 830 nm central wavelength for non invasive examination of the structure of parchment, some covered with iron gall ink, is presented. It is shown that both the parchment and the ink applied are sufficiently transparent to light of this wavelength. In the study, Spectral OCT (SOCT) as well as Polarisation Sensitive OCT (PS-OCT) techniques were used to obtain cross-sectional images of samples of parchment based on scattering properties. The second technique was additionally employed to recover the birefringence properties and the optical axis orientations of the sample. It was shown that freshly produced parchment exhibits a degree of birefringence. However, this property declines with ageing, and samples of old parchment completely depolarise the incident light.

scholarly journals Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model

2021 ◽  
Author(s):  
Timothy Wan Hei Luk
Keyword(s):  
Optical Coherence Tomography ◽  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Near Infrared ◽  
Imaging Modality ◽  
Preclinical Study ◽  
Infrared Light ◽  
Target Tissue ◽  
Optical Coherence

Optical coherence tomography (OCT) is an imaging modality that uses near infrared light interferometry for non-invasive, near-histological resolution imaging at the micron level. Concepts from dynamic light scattering (DLS) can be adapted to OCT to detect and measure the motions in the target tissue. Tissue dynamics can be observed by measuring the speckle decorrelation time (DT) of the tissue. DT analysis was performed in a preclinical study to demonstrate the repeatability and feasibility of using DLS-OCT to observe mouse tumours undergoing cisplatin treatment over a 48-hour period. Differences in the average DT data were observed for control and cisplatin-injected mice. Image segmentation based on DT values was also performed to subtract the DT contributions of pixels at blood vessel locations, resulting in the improvement of average DT calculations of the tumour tissue. The results presented are a preliminary step to analyzing and monitoring tumour growth and treatment response in vivo.

scholarly journals Concept for Markerless 6D Tracking Employing Volumetric Optical Coherence Tomography

Sensors ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 2678
Author(s):  
Matthias Schlüter ◽  
Lukas Glandorf ◽  
Martin Gromniak ◽  
Thore Saathoff ◽  
Alexander Schlaefer
Keyword(s):  
Optical Coherence Tomography ◽  
Near Infrared ◽  
Translational Motion ◽  
Optical Tracking ◽  
Infrared Light ◽  
Optical Coherence ◽  
Geometrical Structures ◽  
Structured Surfaces ◽  
Out Of Plane ◽  
Micrometer Scale

Optical tracking systems are widely used, for example, to navigate medical interventions. Typically, they require the presence of known geometrical structures, the placement of artificial markers, or a prominent texture on the target’s surface. In this work, we propose a 6D tracking approach employing volumetric optical coherence tomography (OCT) images. OCT has a micrometer-scale resolution and employs near-infrared light to penetrate few millimeters into, for example, tissue. Thereby, it provides sub-surface information which we use to track arbitrary targets, even with poorly structured surfaces, without requiring markers. Our proposed system can shift the OCT’s field-of-view in space and uses an adaptive correlation filter to estimate the motion at multiple locations on the target. This allows one to estimate the target’s position and orientation. We show that our approach is able to track translational motion with root-mean-squared errors below 0.25 mm and in-plane rotations with errors below 0.3°. For out-of-plane rotations, our prototypical system can achieve errors around 0.6°.

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