Diffusion tensor imaging of deep gray matter in children treated for brain malignancies

Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms, central nervous system inflammation, atrophy, and demyelination that cannot be accounted for by lesion load alone remain to be elucidated. Purpose To evaluate the normal-appearing deep gray matter in patients with primary and secondary progressive multiple sclerosis, diffusion tensor imaging was used in this study. Material and Methods In 14 multiple sclerosis patients with primary and secondary progressive multiple sclerosis, axial echo-planar single-shot diffusion tensor imaging sequences with 32 diffusion-encoding directions and axial FLAIR sequences were acquired on a 3T system using an eight-channel SENSE head coil. FLAIR hyperintense multiple sclerosis lesions were outlined semi-automatically and normal-appearing deep gray matter was outlined manually (caudate nucleus, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus). Fractional anisotropy and mean diffusivity values within the normal-appearing deep gray matter for the two groups were compared. Results Interhemispheric differences in mean diffusivity values (but not in fractional anisotropy), were significantly higher in primary progressive multiple sclerosis than in secondary progressive multiple sclerosis for the substantia nigra ( P = 0.04) and the putamen ( P = 0.021). Volumes, mean diffusivity, or fractional anisotropy of the remaining normal-appearing deep gray matter did not differ significantly. Conclusion This study showed a higher interhemispheric difference in the mean diffusivity in the substantia nigra and putamen in patients with primary progressive multiple sclerosis than in those with secondary progressive multiple sclerosis. These changes may represent edema, as well as axonal and myelin loss that can affect the normal-appearing deep gray matter of the two hemispheres differently and may point to differences in the laterality of motor symptoms.

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Anatomical characterization of ADHD using an atlas-based analysis: A diffusion tensor imaging study

The EuroBiotech Journal ◽

10.24190/issn2564-615x/2017/01.08 ◽

2017 ◽

Vol 1 (1) ◽

pp. 46-56 ◽

Cited By ~ 2

Author(s):

Niyazi Acer ◽

Nazan Dolu ◽

Gokmen Zararsiz ◽

Mehmet Sait Dogan ◽

Kazim Gumus ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Substantia Nigra ◽

Gray Matter ◽

Diffusion Tensor ◽

Mean Diffusivity ◽

The Body ◽

Children With Adhd ◽

Diffusion Characteristics ◽

Left And Right ◽

Deep Gray Matter

Abstract Purpose: To examine brain diffusion characteristics in pediatric patients with attention deficit hyperactivity disorder (ADHD) using diffusion tensor imaging (DTI) and an atlas-based anatomical analysis of the whole brain and to investigate whether these images have unique characteristics that can support functional diagnoses. Materials and Methods: Seventeen children with ADHD and ten control subjects (all age-matched) underwent MRI scans. The Institutional Ethics Board approved this study. Morphometric analysis was performed using MriStudio software. The diffusion images were normalized using a linear transformation, followed by large deformation diffeomorphic metric mapping (LDDMM). For 189 parcellated brain regions, the volume, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured. Results: Children with ADHD were found to have increase in the body of lateral ventricle volumes compared to the control. Increased MD was found in the deep gray matter, amygdala, thalamus, substantia nigra, and also the cerebellum left and right side. Increased RD was found in the deep gray matter, caudate, thalamus, substantia nigra and hippocampus left and right side compared to the control. Significant elevated FA was found in the bilateral splenium of the corpus callosum in ADHD patients. Conclusion: Children with ADHD display abnormal diffusion characteristics and anatomical features compared to healthy controls. DTI can provide sensitive information on integrity of white matter (WM) and intra-WM structures in ADHD.

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Diffusion tensor imaging of deep gray matter brain structures: Effects of age and iron concentration

Neurobiology of Aging ◽

10.1016/j.neurobiolaging.2008.04.013 ◽

2010 ◽

Vol 31 (3) ◽

pp. 482-493 ◽

Cited By ~ 108

Author(s):

Adolf Pfefferbaum ◽

Elfar Adalsteinsson ◽

Torsten Rohlfing ◽

Edith V. Sullivan

Keyword(s):

Diffusion Tensor Imaging ◽

Gray Matter ◽

Diffusion Tensor ◽

Iron Concentration ◽

Brain Structures ◽

Deep Gray Matter

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Combining Diffusion Tensor Imaging and Gray Matter Volumetry to Investigate Motor Functioning in Chronic Stroke

PLoS ONE ◽

10.1371/journal.pone.0125038 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125038 ◽

Cited By ~ 6

Author(s):

Ming Yang ◽

Ya-ru Yang ◽

Hui-jun Li ◽

Xue-song Lu ◽

Yong-mei Shi ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Gray Matter ◽

Diffusion Tensor ◽

Chronic Stroke ◽

Motor Functioning

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Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study

Cerebral Cortex ◽

10.1093/cercor/bhaa232 ◽

2020 ◽

Vol 31 (1) ◽

pp. 396-409

Author(s):

Alexandrine Morand ◽

Shailendra Segobin ◽

Grégory Lecouvey ◽

Julie Gonneaud ◽

Francis Eustache ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Prospective Memory ◽

Gray Matter ◽

Diffusion Tensor ◽

Imaging Study ◽

Age Related ◽

Young Subjects ◽

Anterior Prefrontal Cortex ◽

And Diffusion

Abstract Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray matter and microstructural white matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, whereas there was no significant correlation in healthy young subjects. According to the literature, these tracts are connected to the anterior prefrontal cortex and the thalamus, 2 structures involved in TBPM. These results confirm the view that a disconnection process occurs in aging and contributes to cognitive decline.

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Diffusion Tensor Imaging Study of Subcortical Gray Matter in CADASIL

Stroke ◽

10.1161/hs0901.094255 ◽

2001 ◽

Vol 32 (9) ◽

pp. 2049-2054 ◽

Cited By ~ 31

Author(s):

N. Molko ◽

S. Pappata ◽

J.F. Mangin ◽

C. Poupon ◽

K. Vahedi ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Gray Matter ◽

Diffusion Tensor ◽

Imaging Study ◽

Diffusion Tensor Imaging Study

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Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease

The Neuroradiology Journal ◽

10.1177/1971400916665378 ◽

2016 ◽

Vol 29 (6) ◽

pp. 417-424 ◽

Cited By ~ 6

Author(s):

Allison Bradbury ◽

David Peterson ◽

Charles Vite ◽

Steven Chen ◽

N Matthew Ellinwood ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

White Matter ◽

Mr Imaging ◽

Gray Matter ◽

Diffusion Tensor ◽

Ex Vivo ◽

Small Animal ◽

Krabbe Disease ◽

Adc Values ◽

The Brain

Purpose The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. Methods An 11-week-old Krabbe dog was euthanized after disease progression. The brain was removed and was placed in a solution of 10% formalin. MR imaging was performed and compared to the brain images of a normal dog that was similarly fixed post-mortem. Both brains were scanned using similar protocols on a 7 T small-animal MRI system. For each brain, maps of ADC, FA, and RD were calculated for 11 white-matter regions and five control gray-matter regions. Results Large decreases in FA values, increases in ADC values, and increases in RD (consistent with demyelination) values, were seen in white matter of the Krabbe brain but not gray matter. ADC values in gray matter of the Krabbe brain were decreased by approximately 29% but increased by approximately 3.6% in white matter of the Krabbe brain. FA values in gray matter were decreased by approximately 3.3% but decreased by approximately 29% in white matter. RD values were decreased by approximately 27.2% in gray matter but increased by approximately 20% in white matter. Conclusion We found substantial abnormalities of FA, ADC, and RD values in an ex vivo canine Krabbe brain.

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