scholarly journals Combining Diffusion Tensor Imaging and Gray Matter Volumetry to Investigate Motor Functioning in Chronic Stroke

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125038 ◽  
Author(s):  
Ming Yang ◽  
Ya-ru Yang ◽  
Hui-jun Li ◽  
Xue-song Lu ◽  
Yong-mei Shi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Chronic Stroke ◽  
Motor Functioning

scholarly journals Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study

2020 ◽  
Vol 31 (1) ◽  
pp. 396-409
Author(s):  
Alexandrine Morand ◽  
Shailendra Segobin ◽  
Grégory Lecouvey ◽  
Julie Gonneaud ◽  
Francis Eustache ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Prospective Memory ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Age Related ◽  
Young Subjects ◽  
Anterior Prefrontal Cortex ◽  
And Diffusion

Abstract Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray matter and microstructural white matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, whereas there was no significant correlation in healthy young subjects. According to the literature, these tracts are connected to the anterior prefrontal cortex and the thalamus, 2 structures involved in TBPM. These results confirm the view that a disconnection process occurs in aging and contributes to cognitive decline.

scholarly journals Diffusion Tensor Imaging Study of Subcortical Gray Matter in CADASIL

Stroke ◽  
2001 ◽  
Vol 32 (9) ◽  
pp. 2049-2054 ◽  
Author(s):  
N. Molko ◽  
S. Pappata ◽  
J.F. Mangin ◽  
C. Poupon ◽  
K. Vahedi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Diffusion Tensor Imaging Study

scholarly journals Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease

2016 ◽  
Vol 29 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Allison Bradbury ◽  
David Peterson ◽  
Charles Vite ◽  
Steven Chen ◽  
N Matthew Ellinwood ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Mr Imaging ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Ex Vivo ◽  
Small Animal ◽  
Krabbe Disease ◽  
Adc Values ◽  
The Brain

Purpose The goal of this study was to compare the diffusion tensor imaging (DTI) metrics from an end-stage canine Krabbe brain evaluated by MR imaging ex vivo to those of a normal dog brain. We hypothesized that the white matter of the canine Krabbe brain would show decreased fractional anisotropy (FA) values and increased apparent diffusion coefficient (ADC) and radial diffusivity (RD) values. Methods An 11-week-old Krabbe dog was euthanized after disease progression. The brain was removed and was placed in a solution of 10% formalin. MR imaging was performed and compared to the brain images of a normal dog that was similarly fixed post-mortem. Both brains were scanned using similar protocols on a 7 T small-animal MRI system. For each brain, maps of ADC, FA, and RD were calculated for 11 white-matter regions and five control gray-matter regions. Results Large decreases in FA values, increases in ADC values, and increases in RD (consistent with demyelination) values, were seen in white matter of the Krabbe brain but not gray matter. ADC values in gray matter of the Krabbe brain were decreased by approximately 29% but increased by approximately 3.6% in white matter of the Krabbe brain. FA values in gray matter were decreased by approximately 3.3% but decreased by approximately 29% in white matter. RD values were decreased by approximately 27.2% in gray matter but increased by approximately 20% in white matter. Conclusion We found substantial abnormalities of FA, ADC, and RD values in an ex vivo canine Krabbe brain.

scholarly journals Predicting functional motor potential in chronic stroke patients using diffusion tensor imaging

2011 ◽  
Vol 33 (5) ◽  
pp. 1040-1051 ◽  
Author(s):  
Robert Lindenberg ◽  
Lin L. Zhu ◽  
Theodor Rüber ◽  
Gottfried Schlaug
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Chronic Stroke ◽  
Stroke Patients ◽  
Motor Potential

Cognition and gray and white matter characteristics of presymptomatic C9orf72 repeat expansion

Neurology ◽  
2017 ◽  
Vol 89 (12) ◽  
pp. 1256-1264 ◽  
Author(s):  
Janne M. Papma ◽  
Lize C. Jiskoot ◽  
Jessica L. Panman ◽  
Elise G. Dopper ◽  
Tom den Heijer ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Gray Matter Volume ◽  
Repeat Expansion ◽  
White Matter Integrity ◽  
Matter Volume ◽  
Presymptomatic Stage ◽  
And Diffusion

Objective:To investigate cognitive function, gray matter volume, and white matter integrity in the presymptomatic stage of chromosome 9 open reading frame 72 repeat expansion (C9orf72RE).Methods:Presymptomatic C9orf72RE carriers (n = 18) and first-degree family members without a pathogenic expansion (healthy controls [HC], n = 15) underwent a standardized protocol of neuropsychological tests, T1-weighted MRI, and diffusion tensor imaging within our cohort study of autosomal dominant frontotemporal dementia (FTD). We investigated group differences in cognitive function, gray matter volume through voxel-based morphometry, and white matter integrity by means of tract-based spatial statistics. We correlated cognitive change with underlying gray or white matter.Results:Our data demonstrate lower scores on letter fluency, Stroop card I, and Stroop card III, accompanied by white matter integrity loss in tracts connecting the frontal lobe, the thalamic radiation, and tracts associated with motor functioning in presymptomatic C9orf72RE compared with HC. In a subgroup of C9orf72RE carriers above 40 years of age, we found gray matter volume loss in the thalamus, cerebellum, and parietal and temporal cortex. We found no significant relationship between subtle cognitive decline and underlying gray or white matter.Conclusions:This study demonstrates that a decline in cognitive functioning, white matter integrity, and gray matter volumes are present in presymptomatic C9orf72RE carriers. These findings suggest that neuropsychological assessment, T1-weighted MRI, and diffusion tensor imaging might be useful to identify early biomarkers in the presymptomatic stage of FTD or amyotrophic lateral sclerosis.

scholarly journals Diffusion tensor imaging of deep gray matter in children treated for brain malignancies

2013 ◽  
Vol 30 (4) ◽  
pp. 631-638 ◽  
Author(s):  
Alena Horská ◽  
Anna Nidecker ◽  
Jarunee Intrapiromkul ◽  
Firouzeh Tannazi ◽  
Siamak Ardekani ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Deep Gray Matter
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