Interleukin-1 expression in normal motor endplates and muscle fibers showing neurogenic changes

The striated swim bladder muscles of the weakfish Cynoscion regalis are deep red in color but cannot be classified histologically as having typical red fibers. The muscle fibers are homogeneous and average 29.6 ± 5.3 μm in diameter, one-fifth the diameter of the adjacent hypaxialis fibers. Each muscle fiber contains thin, ribbonlike myofibrils which are radially arranged around a central core of mitochondria, glycogen, and sarcoplasmic reticulum. Myofibrils are extremely regular in pattern. Triads occur at the Z line. Numerous mitochondria and muscle nuclei are located at the periphery of each muscle fiber. The muscle fibers are multiply innervated with motor endplates distributed along their entire lengths. Well-developed folding of the postsynaptic membrane, not previously reported in fishes, is present at the motor endplate.

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Repression of myosin isoforms in developing and denervated skeletal muscle fibers originates near motor endplates

Developmental Dynamics ◽

10.1002/(sici)1097-0177(200001)217:1<50::aid-dvdy5>3.0.co;2-1 ◽

2000 ◽

Vol 217 (1) ◽

pp. 50-61 ◽

Cited By ~ 10

Author(s):

Benjamin W. C. Rosser ◽

Cindy M. Farrar ◽

Natasha K. Crellin ◽

Linda B. Andersen ◽

Everett Bandman

Keyword(s):

Skeletal Muscle ◽

Muscle Fibers ◽

Myosin Isoforms ◽

Motor Endplates ◽

Skeletal Muscle Fibers

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Early effects of carbachol on the morphology of motor endplates of mammalian skeletal muscle fibers

Muscle & Nerve ◽

10.1002/mus.21508 ◽

2010 ◽

Vol 41 (3) ◽

pp. 399-405 ◽

Cited By ~ 1

Author(s):

Tilman Voigt

Keyword(s):

Skeletal Muscle ◽

Muscle Fibers ◽

Mammalian Skeletal Muscle ◽

Motor Endplates ◽

Skeletal Muscle Fibers ◽

Early Effects

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Mitochondrial Changes in Choline-Deficient Rat Myocardium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100305 ◽

1968 ◽

Vol 26 ◽

pp. 112-113

Author(s):

F. G. Zaki

Keyword(s):

Muscle Fibers ◽

Liver Mitochondria ◽

Ultrastructural Changes ◽

Choline Deficiency ◽

Nutritional Disorder ◽

Low Protein ◽

Structural Abnormalities ◽

Cross Striation ◽

Pericardial Edema ◽

Myocardial Lesions

Choline-deficiency was induced in Holtzman young rats of both sexes by feeding them a high fat - low protein diet.Preliminary studies of the ultrastructural changes in the myocardium of these animals have been recently reported from this laboratory. Myocardial lesions first appeared in the form of intraventricular mural thrombi, loss of cross striation of muscle fibers and focal necrosis of muscle cells associated with interstitial myocarditis. Prolonged choline-deficiency induced cardiomegaly associated with pericardial edema.During the early phase of this nutritional disorder, heart mitochondria - despite of not showing any swelling similar to that usually encountered in liver mitochondria of the same animal - ware the most ubiquitous site of marked structural abnormalities. Early changes in mitochondria appeared as vacuolation, disorganization, disruption and loss of cristae. Degenerating mitochondria were often seen quite enlarged and their matrix was replaced by whorls of myelin figures resembling lysosomal structures especially where muscle fibers were undergoing necrosis. In some areas, mitochondria appeared to be unusually clumped together where some contained membranelined vacuoles and others enclosed dense bodies and granular inclusions.

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The “KIMWIPE” Effect in Ultra-Thin Cryosections

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100119119 ◽

1985 ◽

Vol 43 ◽

pp. 458-459

Author(s):

I. Taylor ◽

P. Ingram ◽

J.R. Sommer

Keyword(s):

Skeletal Muscle ◽

Electrical Stimulation ◽

Muscle Fibers ◽

Ice Crystals ◽

Crystal Formation ◽

Ice Crystal ◽

Thin Sections ◽

Skeletal Muscle Fibers ◽

Freeze Dried ◽

Ice Crystal Formation

In studying quick-frozen single intact skeletal muscle fibers for structural and microchemical alterations that occur milliseconds, and fractions thereof, after electrical stimulation, we have developed a method to compare, directly, ice crystal formation in freeze-substituted thin sections adjacent to all, and beneath the last, freeze-dried cryosections. We have observed images in the cryosections that to our knowledge have not been published heretofore (Figs.1-4). The main features are that isolated, sometimes large regions of the sections appear hazy and have much less contrast than adjacent regions. Sometimes within the hazy regions there are smaller areas that appear crinkled and have much more contrast. We have also observed that while the hazy areas remain still, the regions of higher contrast visibly contract in the beam, often causing tears in the sections that are clearly not caused by ice crystals (Fig.3, arrows).

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