Gene expression changes after ionizing radiation in endothelial cells derived from human endometrial cancer-preliminary outcomes

2014 ◽  
Vol 289 (6) ◽  
pp. 1315-1323 ◽  
Author(s):  
Ting Liu ◽  
Xuelian Du ◽  
Xiugui Sheng
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endometrial Cancer ◽  
Ionizing Radiation

scholarly journals Stimulation of endothelin-1 gene expression by insulin in endothelial cells.

1991 ◽  
Vol 266 (34) ◽  
pp. 23251-23256
Author(s):  
F.J. Oliver ◽  
G. de la Rubia ◽  
E.P. Feener ◽  
M.E. Lee ◽  
M.R. Loeken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Endothelin 1 ◽  
Stimulation Of

scholarly journals Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 621
Author(s):  
Maria Grazia Muoio ◽  
Marianna Talia ◽  
Rosamaria Lappano ◽  
Andrew H. Sims ◽  
Veronica Vella ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Bioinformatic Analysis ◽  
Tube Formation ◽  
Endothelial Cell Proliferation ◽  
Diabetic Patients ◽  
Obesity And Diabetes ◽  
Er Positive

Background: Breast cancer (BC) mortality is increased among obese and diabetic patients. Both obesity and diabetes are associated with dysregulation of both the IGF-1R and the RAGE (Receptor for Advanced Glycation End Products) pathways, which contribute to complications of these disorders. The alarmin S100A7, signaling through the receptor RAGE, prompts angiogenesis, inflammation, and BC progression. Methods: We performed bioinformatic analysis of BC gene expression datasets from published studies. We then used Estrogen Receptor (ER)-positive BC cells, CRISPR-mediated IGF-1R KO BC cells, and isogenic S100A7-transduced BC cells to investigate the role of IGF-1/IGF-1R in the regulation of S100A7 expression and tumor angiogenesis. To this aim, we also used gene silencing and pharmacological inhibitors, and we performed gene expression and promoter studies, western blotting analysis, ChIP and ELISA assays, endothelial cell proliferation and tube formation assay. Results: S100A7 expression correlates with worse prognostic outcomes in human BCs. In BC cells, the IGF-1/IGF-1R signaling engages STAT3 activation and its recruitment to the S100A7 promoter toward S100A7 increase. In human vascular endothelial cells, S100A7 activates RAGE signaling and prompts angiogenic effects. Conclusions: In ER-positive BCs the IGF-1 dependent activation of the S100A7/RAGE signaling in adjacent endothelial cells may serve as a previously unidentified angiocrine effector. Targeting S100A7 may pave the way for a better control of BC, particularly in conditions of unopposed activation of the IGF-1/IGF-1R axis.

scholarly journals Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells

1991 ◽  
Vol 266 (24) ◽  
pp. 16188-16192 ◽  
Author(s):  
M.E. Lee ◽  
D.H. Temizer ◽  
J.A. Clifford ◽  
T. Quertermous
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Binding Protein ◽  
Endothelin 1

Gene expression profiles of glucose toxicity-exposed islet microvascular endothelial cells

2018 ◽  
Vol 25 (4) ◽  
pp. e12450 ◽  
Author(s):  
Mingming Liu ◽  
Wenbao Lu ◽  
Qunxing Hou ◽  
Bing Wang ◽  
Youming Sheng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Microvascular Endothelial Cells ◽  
Glucose Toxicity ◽  
Microvascular Endothelial

Lipoprotein apheresis of hypercholesterolemic patients mediates vasoprotective gene expression in human endothelial cells

2013 ◽  
Vol 14 (1) ◽  
pp. 107-113 ◽  
Author(s):  
Henning Morawietz ◽  
Winfried Goettsch ◽  
Melanie Brux ◽  
Manja Reimann ◽  
Stefan R. Bornstein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Human Endothelial Cells ◽  
Lipoprotein Apheresis

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

2013 ◽  
Vol 90 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Kwang Seok Kim ◽  
Jung Eun Kim ◽  
Kyu Jin Choi ◽  
Sangwoo Bae ◽  
Dong Ho Kim
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Ionizing Radiation ◽  
Cellular Senescence

scholarly journals Zyxin Mediation of Stretch-Induced Gene Expression in Human Endothelial Cells

2010 ◽  
Vol 107 (7) ◽  
pp. 898-902 ◽  
Author(s):  
Agnieszka Wójtowicz ◽  
Sahana Suresh Babu ◽  
Li Li ◽  
Norbert Gretz ◽  
Markus Hecker ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Human Endothelial Cells
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