Interaction of tobacco chewing and smoking habit with interleukin 6 promoter polymorphism in oral precancerous lesions and oral cancer

2021 ◽  
Author(s):  
Yadvendra Shahi ◽  
Sayali Mukherjee ◽  
Fahad M. Samadi
Keyword(s):  
Oral Cancer ◽  
Interleukin 6 ◽  
Precancerous Lesions ◽  
Smoking Habit ◽  
Promoter Polymorphism ◽  
Oral Precancerous Lesions ◽  
Tobacco Chewing

Awareness regarding oral cancer and oral precancerous lesions among rural population of Belgaum district, India

2016 ◽  
Vol 23 (3) ◽  
pp. 27-35 ◽  
Author(s):  
Roopali Sankeshwari ◽  
Anil Ankola ◽  
Mamata Hebbal ◽  
Sidramesh Muttagi ◽  
Nilam Rawal
Keyword(s):  
Oral Cancer ◽  
Rural Population ◽  
Precancerous Lesions ◽  
Oral Precancerous Lesions

scholarly journals Complete Blood Count as a Diagnostic Marker in Oral Lichen Planus

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 1766-1771
Author(s):  
Indra G ◽  
Maragathavalli G ◽  
Deepika Rajendran
Keyword(s):  
Oral Cancer ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Blood Count ◽  
Diagnostic Marker ◽  
Complete Blood Count ◽  
Precancerous Lesions ◽  
Oral Submucous Fibrosis ◽  
Oral Precancerous Lesions ◽  
Oral Lichen

Oral precancerous lesions and conditions like oral lichen planus, leukoplakia, or oral submucous fibrosis have the potential to develop into oral cancer. Oral cancer accounts for approximately 3 % of all malignancies. Oral lichen planus is a premalignant condition occurring in the oral cavity due to various factors. Blood investigations are routinely done minimally invasive procedures carried out for various diagnostic purposes. The study aims to identify if the complete blood count (CBC) can be used as a pathologic diagnostic marker in an oral premalignant disorder like oral lichen planus. A total of 64 patients (38 female, 26 male) were taken into the study between the period July 2019 - March 2020. Each patient is exposed to blood investigations, and their results are studied. The results of the study show a minimal variation in the blood results. In conclusion, to determine if it can be used as a pathological diagnostic marker in premalignant disorders like oral lichen planus, further studies must be carried out in larger populations.

Strong Association of Interleukin-6 -174 G>C Promoter Polymorphism with Increased Risk of Oral Cancer

2006 ◽  
Vol 21 (4) ◽  
pp. 246-250 ◽  
Author(s):  
E. Vairaktaris ◽  
A. Yiannopoulos ◽  
A. Vylliotis ◽  
C. Yapijakis ◽  
S. Derka ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Interleukin 6 ◽  
Odds Ratio ◽  
Strong Association ◽  
Promoter Polymorphism ◽  
Healthy Controls ◽  
Exact Test ◽  
Factors Associated ◽  
Increased Risk ◽  
Age And Sex

In view of the recently found contribution of factors associated with thrombosis and inflammation to carcinogenesis, we investigated the possible association of interleukin-6 (IL-6) with an increased risk of oral cancer. In DNA samples of 162 patients with oral squamous cell carcinoma and 156 healthy controls of comparable ethnicity, age and sex, we studied the -174 G>C polymorphism in the IL-6 gene, which affects its transcription. C allele frequencies were significantly increased in patients compared to controls, 42.6% versus 23.1% (p<0.001). The CC homozygotes had a 7-fold greater risk of developing oral cancer (odds ratio 7.39, 95% CI 2.61–20.92), while the GC heterozygotes had a 4-fold greater risk (odds ratio 3.74, 95% CI 2.29–6.11). A significant increase in C alleles was observed in patients regardless of their smoking or alcohol consumption habits, early or advanced stage of cancer, and presence or absence of a family history for cancer or thrombophilia (p<0.001; Fisher's exact test). These findings suggest that the –174 G>C polymorphism, by affecting IL-6 gene expression, is strongly associated with oral oncogenesis.

Strong association of interleukin-6 -174 G>C promoter polymorphism with increased risk of oral cancer

2006 ◽  
Vol 21 (4) ◽  
pp. 246-250 ◽  
Author(s):  
E. Vairaktaris ◽  
A. Yiannopoulos ◽  
A. Vylliotis ◽  
C. Yapijakis ◽  
S. Derka ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Interleukin 6 ◽  
Strong Association ◽  
Promoter Polymorphism ◽  
Increased Risk

scholarly journals Prevalence of Oral Precancerous and Cancerous Lesions in Elderly Malaysians

1997 ◽  
Vol 9 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Tara B Taiyeb Ali ◽  
Raja Latifah Raja Jalaliuddin ◽  
Ishak Abdul Razak ◽  
Rosnah Binti Zain
Keyword(s):  
Oral Cancer ◽  
Precancerous Lesions ◽  
Elderly Subjects ◽  
Oral Habits ◽  
Indian Origin ◽  
Cancerous Lesions ◽  
Oral Precancerous Lesions ◽  
Ethnic Distribution

A house to house survey on elderly subjects aged 60 years old and above was undertaken in a large district in Malaysia. A total of 486 subjects in randomly selected Enumeration Blocks were interviewed and examined. The prevalence of oral precancerous lesions was recorded at 3.3%, of which leukoplakia was the most common. When the ethnic distribution of these oral precancerous and cancerous (OPC) lesions was compared, 72% of those inflicted were Indians. Oral cancer was detected in two subjects (0.4%), both of whom were of Indian origin. Among subjects with OPC lesions, 4.2% were smokers, 12.7% were betelquid chewers, 11.8% had indulged in both habits, whilst one subject had not practised any of the oral habits of interest (0.4%). The findings suggest the occurrence of OPC lesions to be related to betelquid chewing.

Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions

Head & Neck ◽  
2009 ◽  
Vol 32 (8) ◽  
pp. 1028-1039 ◽  
Author(s):  
Chien-Yu Lin ◽  
Wen-Ho Chen ◽  
Chun-Ta Liao ◽  
I-How Chen ◽  
Ching-Chi Chiu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Progression ◽  
Prognostic Value ◽  
Precancerous Lesions ◽  
Positive Association ◽  
Oral Precancerous Lesions ◽  
Glucose Regulated Protein

scholarly journals Treg: A Promising Immunotherapeutic Target in Oral Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Yujing Zhang ◽  
Jihua Guo ◽  
Rong Jia
Keyword(s):  
Oral Cancer ◽  
Inflammatory Diseases ◽  
Precancerous Lesions ◽  
Treg Cells ◽  
Multiple Roles ◽  
Oral Diseases ◽  
Main Challenge ◽  
Self Tolerance ◽  
Oral Precancerous Lesions ◽  
Minimize Tissue Damage

With the pandemic of COVID-19, maintenance of oral health has increasingly become the main challenge of global health. Various common oral diseases, such as periodontitis and oral cancer, are closely associated with immune disorders in the oral mucosa. Regulatory T cells (Treg) are essential for maintaining self-tolerance and immunosuppression. During the process of periodontitis and apical periodontitis, two typical chronic immune-inflammatory diseases, Treg contributes to maintain host immune homeostasis and minimize tissue damage. In contrast, in the development of oral precancerous lesions and oral cancer, Treg is expected to be depleted or down-regulated to enhance the anti-tumor immune response. Therefore, a deeper understanding of the distribution, function, and regulatory mechanisms of Treg cells may provide a prospect for the immunotherapy of oral diseases. In this review, we summarize the distribution and multiple roles of Treg in different oral diseases and discuss the possible mechanisms involved in Treg cell regulation, hope to provide a reference for future Treg-targeted immunotherapy in the treatment of oral diseases.

Sign in / Sign up

Export Citation Format

Share Document