RETRACTED ARTICLE: Reproductive toxicity and pathomorphological changes in rats after chronic oral exposure to low-dose depleted uranium

2011 ◽  
Vol 52 (1) ◽  
pp. 169-169
Author(s):  
Yuhui Hao ◽  
Rong Li ◽  
Yanbing Leng ◽  
Jiong Ren ◽  
Jing Liu ◽  
...  
Keyword(s):  
Low Dose ◽  
Reproductive Toxicity ◽  
Depleted Uranium ◽  
Oral Exposure ◽  
Retracted Article

scholarly journals Effects of Oral Domoic Acid Exposure on Maternal Reproduction and Infant Birth Characteristics in a Preclinical Nonhuman Primate Model

2018 ◽  
Author(s):  
Thomas M. Burbacher ◽  
Kimberly S. Grant ◽  
Rebekah Petroff ◽  
Sara Shum ◽  
Brenda Crouthamel ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
High Frequency ◽  
Domoic Acid ◽  
Low Dose ◽  
Reproductive Toxicity ◽  
Physical Characteristics ◽  
Oral Exposure ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Regulatory Guidelines

AbstractDomoic Acid (DA) is a naturally-occurring excitotoxin, produced by marine algae, which can bioaccumulate in shellfish and finfish. The consumption of seafood contaminated with DA is associated with gastrointestinal illness that, in the case of high DA exposure, can evolve into a spectrum of responses ranging from agitation to hallucinations, memory loss, seizures and coma. Because algal blooms that produce DA are becoming more widespread and very little is known about the dangers of chronic, low-dose exposure, we initiated a preclinical study focused on the reproductive and developmental effects of DA in a nonhuman primate model. To this end, 32 adult female Macaca fascicularis monkeys were orally exposed to 0, 0.075 or 0.15 mg/kg/day DA on a daily basis, prior to and during pregnancy. Females were bred to non-exposed males and infants were evaluated at birth. Results from this study provided no evidence of changes in DA plasma concentrations with chronic exposure. DA exposure was not associated with reproductive toxicity or adverse changes in the physical characteristics of newborns. However, in an unanticipated finding, our clinical observations battery revealed the presence of subtle neurological effects in the form of intentional tremors in the exposed adult females. While females in both dose groups displayed increased tremoring, the effect was dose-dependent and observed at a higher frequency in females exposed to 0.15 mg/kg/day. These results demonstrate that chronic, low-level exposure to DA is associated with injury to the adult CNS and suggest that current regulatory guidelines designed to protect human health may not be adequate for high-frequency shellfish consumers.Highlights1) Domoic acid acts as a tremoragen after chronic, low-dose oral exposure in adults.2) Exposure across pregnancy does not result in maternal reproductive toxicity.3) In-utero exposure does not adversely impact physical characteristics of exposed newborns.4) Current regulatory guidelines may not adequately protect high-frequency shellfish consumers from DA-induced neurological injury.

scholarly journals A study Assessing the Genotoxicity in Rats after Chronic Oral Exposure to a Low Dose of Depleted Uranium

2009 ◽  
Vol 50 (6) ◽  
pp. 521-528 ◽  
Author(s):  
Yuhui HAO ◽  
Rong LI ◽  
Yanbing LENG ◽  
Jiong REN ◽  
Jing LIU ◽  
...  
Keyword(s):  
Low Dose ◽  
Depleted Uranium ◽  
Oral Exposure

scholarly journals The Reproductive Effects in Rats after Chronic Oral Exposure to Low-dose Depleted Uranium

2012 ◽  
Vol 53 (3) ◽  
pp. 377-384 ◽  
Author(s):  
Yuhui HAO ◽  
Rong LI ◽  
Yanbing LENG ◽  
Jiong REN ◽  
Jing LIU ◽  
...  
Keyword(s):  
Low Dose ◽  
Depleted Uranium ◽  
Oral Exposure ◽  
Reproductive Effects

103. Multi-Generation Reproductive Toxicity Study of Implanted Depleted Uranium in Rats

2004 ◽  
Author(s):  
D. Arfsten ◽  
A. Thitoff ◽  
E. Johnson ◽  
A. Jung ◽  
W. Jederberg ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Depleted Uranium ◽  
Toxicity Study

Male reproductive toxicity of sodium arsenite in mice

2004 ◽  
Vol 23 (8) ◽  
pp. 399-403 ◽  
Author(s):  
Niraj Pant ◽  
R C Murthy ◽  
S P Srivastava
Keyword(s):  
Drinking Water ◽  
Sodium Arsenite ◽  
Sperm Count ◽  
Prostate Gland ◽  
Reproductive Toxicity ◽  
Atomic Absorption Spectrophotometry ◽  
Reproductive Organs ◽  
Oral Exposure ◽  
Human Beings ◽  
Testicular Weight

The effect of chronic oral exposure to arsenic on male mouse testicular and accessory sex organ weights, sperm parameters and testicular marker enzymes was studied. In addition, the distribution of arsenic in reproductive organs was measured using atomic absorption spectrophotometry. Sodium arsenite administered to mice (Mus musculus) via drinking water at a dose of 53.39 βmol/L (4 ppm As) for 365 days caused a decrease in the absolute and relative testicular weight. However, epididymal and accessory sex organ weight was similar to control. The activities of marker testicular enzymes such as sorbitol dehydrogenase, acid phosphatase and 17β-hydroxysteroid dehydrogenase (17β-HSD) were significantly decreased, but those of lactate dehydrogenase and γ-glutamyl transpeptidase (γ-GT) were significantly increased. A decrease in sperm count and sperm motility, along with an increase in abnormal sperm, was observed in arsenite-exposed mice. A significant accumulation of arsenic in testes, epididymis, seminal vesicle and prostate gland was observed in treated animals. Thus long term exposure (365 days) at the dose level of 53.39 μmol/L sodium arsenite (4 ppm As), to which human beings are likely to be exposed via drinking water, may cause testicular and spermatotoxic effect.

TET1 mediated male reproductive toxicity induced by BPA at low dose through Catsper-Ca2+ signaling pathway

2021 ◽  
pp. 118739
Author(s):  
Wen-bo Yuan ◽  
Hong-qiang Chen ◽  
Jing-zhi Li ◽  
Shi-meng Zhou ◽  
Yong Zeng ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Low Dose ◽  
Reproductive Toxicity

Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice

2019 ◽  
Author(s):  
Yann Malaisé ◽  
Corinne Lencina ◽  
Christel Cartier ◽  
Maïwenn Olier ◽  
Sandrine Ménard ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Immune Responses ◽  
Bisphenol A ◽  
Low Dose ◽  
Intestinal Barrier ◽  
Female Offspring ◽  
Oral Exposure ◽  
Gut Barrier ◽  
Cellular Immune Responses ◽  
Cellular Immune

Abstract Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during perinatal period (gestation and/or lactation). We previously demonstrated that perinatal oral exposure to BPA (via gavage of mothers during gestation and lactation) has long-term consequences on immune response and intestinal barrier functions. Due to its adverse effects on several developmental and physiological processes, BPA was removed from consumer products and replaced by chemical substitutes such as BPS or BPF, that are structurally similar and not well studied compare to BPA. Here, we aimed to compare perinatal oral exposure to these bisphenols (BPs) at two doses (5 and 50 mg/kg body weight (BW)/day (d)) on gut barrier and immune system in female offspring mice at adulthood (Post Natal Day PND70). Methods Pregnant female mice were orally exposed to BPA, BPS or BPF at 5 or 50 μg/kg BW/d from 15th day of gravidity to weaning of pups at PostNatal Day (PND) 21. Gut barrier function and the humoral and cellular immune responses of adult offspring (PND70) were analysed at intestinal and systemic levels. Results In female offspring, perinatal oral BP exposure led to adverse effects on intestinal barrier and immune response that were dependant of the BP nature (A, S or F) and dose of exposure. Stronger impacts were observed with BPS at the dose of 5µg/kg BW/d on inflammatory markers in feces associated with an increase of anti-E. coli IgG, revealing a defect of gut barrier. BPA and BPF exposure induced prominent changes at low dose in offspring mice, in term of gut barrier functions and cellular immune responses, provoking an intestinal and systemic Th1/Th17 inflammation. Conclusion These findings provide, for the first time, a comparative study of long-time consequences of BPA, S and F perinatal exposure by oral route in offspring mice. This work warms that it is mandatory to consider immune markers and dose in risk assessment associated to new BPA’s alternatives. Keywords: Bisphenol A, Bisphenol S, Bisphenol F, Immune responses, Perinatal exposure, Intestine, Th1/Th17, immunoglobulin, cytokines

scholarly journals Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells

2020 ◽  
Vol 9 (4) ◽  
pp. 454-460
Author(s):  
Lihua Ren ◽  
Jianhui Liu ◽  
Jialiu Wei ◽  
Yefan Du ◽  
Kaiyue Zou ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Low Dose ◽  
Caspase 3 ◽  
Reproductive Toxicity ◽  
Chronic Effect ◽  
Unfolded Protein ◽  
Induced Apoptosis ◽  
Protein Response ◽  
Protein Reaction

Abstract With increasing air pollution, silica nanoparticles (SiNPs), as a main inorganic member of PM2.5, have gained increasing attention to its reproductive toxicity. Most existing studies focused on the acute exposure, while data regarding the chronic effect of SiNPs on reproduction is limited. Therefore, this study was designed to evaluate the chronic toxicity of SiNPs on spermatocyte cells. The cells were continuously exposed to SiNPs for 1, 10, 20 and 30 generations at dose of 5 μg/ml SiNPs for 24 h per generation after attachment. The results showed that with the increasing generations of the exposure, SiNPs decreased the viability of spermatocyte cells, induced apoptosis and increased the level of reactive oxygen species in spermatocyte cells. Moreover, SiNPs increased the protein expression of GRP-78, p-PERK, IRE1α, ATF6 and Cleaved caspase-3 in spermatocyte cells, suggesting that SiNPs improved unfolded protein response (UPR) and apoptosis. The present results indicated that the long-term and low-dose exposure to SiNPs could induce apoptosis by triggering ROS-mediated UPR in spermatocyte cells.

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