Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats

2010 ◽  
Vol 111 (6) ◽  
pp. 1147-1156 ◽  
Author(s):  
Vladimir Essau Martinez-Bello ◽  
Fabian Sanchis-Gomar ◽  
Ana Lucia Nascimento ◽  
Federico V. Pallardo ◽  
Sandra Ibañez-Sania ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Hematological Parameters ◽  
Sprint Training ◽  
Improve Performance

scholarly journals Physiological aspects of altitude training and the use of altitude simulators

2005 ◽  
Vol 133 (5-6) ◽  
pp. 307-311
Author(s):  
Goran Rankovic ◽  
Dragan Radovanovic
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Training Stimulus ◽  
Endurance Athletes ◽  
Altitude Training ◽  
Moderate Altitude ◽  
Improve Performance ◽  
Hypoxic Conditions ◽  
Training Programmes ◽  
Training Modalities

Altitude training in various forms is widely practiced by athletes and coaches in an attempt to improve sea level endurance. Training at high altitude may improve performance at sea level through altitude acclimatization, which improves oxygen transport and/or utilization, or through hypoxia, which intensifies the training stimulus. This basic physiological aspect allows three training modalities: live high and train high (classic high-altitude training), live low and train high (training through hypoxia), and live high and train low (the new trend). In an effort to reduce the financial and logistical challenges of traveling to high-altitude training sites, scientists and manufactures have developed artificial high-altitude environments, which simulate the hypoxic conditions of moderate altitude (2000-3000 meters). Endurance athletes from many sports have recently started using nitrogen environments, or hypoxic rooms and tents as part of their altitude training programmes. The results of controlled studies on these modalities of high-altitude training, their practical approach, and ethics are summarized.

scholarly journals The use of an Alpine climate in the treatment of immune thrombocytopenic purpura (ITP) in children of the Kyrgyz Republic

2020 ◽  
Vol 11 (2) ◽  
pp. 2498-2504
Author(s):  
Mamatov Sagynali Murzaevich ◽  
Esengeldi Kyzy Aizhamal ◽  
Vityala Yethindra ◽  
Tugolbai Tagaev Jumabekovich ◽  
Arstanbekova Mira Arstanbekovna ◽  
...  
Keyword(s):  
Platelet Count ◽  
High Altitude ◽  
Sea Level ◽  
Immune Thrombocytopenia ◽  
Hematological Parameters ◽  
Complete Recovery ◽  
Kyrgyz Republic ◽  
Treatment Results ◽  
Thrombocytopenic Purpura ◽  
Chronic Immune Thrombocytopenia

The objective of the study is to evaluate the effectiveness of the use of alpine (high-altitude) climatotherapy in the chronic form of immune thrombocytopenia in children. The article presents the results of the treatment of immune thrombocytopenia in children during high altitude climatotherapy. For this type of treatment, the alpine climate of the Tuya-Ashu pass (3200 meters above sea level) in the Kyrgyz Republic used. A 40-day stay in the highlands contributes to the relief of hemorrhagic syndrome and a significant increase in platelet count. Evaluation of the treatment results showed that out of 32 children who received alpine (high-altitude) climatotherapy once, 2 achieved complete and 14 had partial remission. In 11 children, the improvement of clinical and hematological parameters was temporary, and the absence of effect recorded in 5 patients. 50% of children with chronic immune thrombocytopenia (ITP) responded positively to a single course of treatment. Repeated courses of treatment led only to an improvement in clinical and haematological parameters. In our study, we have a case of a complete recovery of a child with immune thrombocytopenia (ITP) after 5 treatments in high altitude conditions.

Hematological Parameters in High Altitude Residents Living at 4355, 4660, and 5500 Meters Above Sea Level

2000 ◽  
Vol 1 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Fabiola León-Velarde ◽  
Alfredo Gamboa ◽  
Jenny A. Chuquiza ◽  
Williams A. Esteba ◽  
Maria Rivera-Chira ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Hematological Parameters

scholarly journals Prolonged Sojourn at Very High Altitude Decreases Sea-Level Anaerobic Performance, Anaerobic Threshold, and Fat Mass

2021 ◽  
Vol 12 ◽  
Author(s):  
Robert K. Szymczak ◽  
Tomasz Grzywacz ◽  
Ewa Ziemann ◽  
Magdalena Sawicka ◽  
Radosław Laskowski
Keyword(s):  
Body Weight ◽  
High Altitude ◽  
Sea Level ◽  
Fat Mass ◽  
Anaerobic Threshold ◽  
Aerobic Power ◽  
Hematological Parameters ◽  
Maximal Aerobic Power ◽  
Anaerobic Performance ◽  
Very High

Background: The influence of high altitude on an organism’s physiology depends on the length and the level of hypoxic exposure it experiences. This study aimed to determine the effect of a prolonged sojourn at very high altitudes (above 3,500m) on subsequent sea-level physical performance, body weight, body composition, and hematological parameters.Materials and Methods: Ten alpinists, nine males and one female, with a mean age of 27±4years, participated in the study. All had been on mountaineering expeditions to 7,000m peaks, where they spent 30±1days above 3,500m with their average sojourn at 4,900±60m. Their aerobic and anaerobic performance, body weight, body composition, and hematological parameters were examined at an altitude of 100m within 7days before the expeditions and 7days after they descended below 3,500m.Results: We found a significant (p<0.01) decrease in maximal anaerobic power (MAPWAnT) from 9.9±1.3 to 9.2±1.3W·kg−1, total anaerobic work from 248.1±23.8 to 228.1±20.1J·kg−1, anaerobic threshold from 39.3±8.0 to 27.8±5.6 mlO2·kg−1·min−1, body fat mass from 14.0±3.1 to 11.5±3.3%, and a significant increase (p<0.05) in maximal tidal volume from 3.2 [3.0–3.2] to 3.5 [3.3–3.9] L after their sojourn at very high attitude. We found no significant changes in maximal aerobic power, maximal oxygen uptake, body weight, fat-free mass, total body water, hemoglobin, and hematocrit.Conclusion: A month-long exposure to very high altitude led to impaired sea-level anaerobic performance and anaerobic threshold, increased maximal tidal volume, and depleted body fat mass, but had no effect on maximal aerobic power, maximal oxygen uptake, or hemoglobin and hematocrit levels.

scholarly journals Effect of high altitude on human placental amino acid transport

2020 ◽  
Vol 128 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Owen. R. Vaughan ◽  
Fredrick Thompson ◽  
Ramón. A. Lorca ◽  
Colleen G. Julian ◽  
Theresa L. Powell ◽  
...  
Keyword(s):  
Birth Weight ◽  
Amino Acid ◽  
High Altitude ◽  
Sea Level ◽  
Amino Acid Transport ◽  
Acid Uptake ◽  
Acid Transport ◽  
Transport Capacity ◽  
System A ◽  
Low Altitude

Women residing at high altitudes deliver infants of lower birth weight than at sea level. Birth weight correlates with placental system A-mediated amino acid transport capacity, and severe environmental hypoxia reduces system A activity in isolated trophoblast and the mouse placenta. However, the effect of high altitude on human placental amino acid transport remains unknown. We hypothesized that microvillous membrane (MVM) system A and system L amino acid transporter activity is lower in placentas of women living at high altitude compared with low-altitude controls. Placentas were collected at term from healthy pregnant women residing at high altitude (HA; >2,500 m; n = 14) or low altitude (LA; <1,700 m; n = 14) following planned, unlabored cesarean section. Birth weight, but not placenta weight, was 13% lower in HA pregnancies (2.88 ± 0.11 kg) compared with LA (3.30 ± 0.07 kg, P < 0.01). MVM erythropoietin receptor abundance, determined by immunoblot, was greater in HA than in LA placentas, consistent with lower placental oxygen levels at HA. However, there was no effect of altitude on MVM system A or L activity, determined by Na+-dependent [14C]methylaminoisobutyric acid uptake and [3H]leucine uptake, respectively. MVM abundance of glucose transporters (GLUTs) 1 and 4 and basal membrane GLUT4 were also similar in LA and HA placentas. Low birth weights in the neonates of women residing at high altitude are not a consequence of reduced placental amino acid transport capacity. These observations are in general agreement with studies of IUGR babies at low altitude, in which MVM system A activity is downregulated only in growth-restricted babies with significant compromise. NEW & NOTEWORTHY Babies born at high altitude are smaller than at sea level. Birth weight is dependent on growth in utero and, in turn, placental nutrient transport. We determined amino acid transport capacity in placentas collected from women resident at low and high altitude. Altitude did not affect system A amino acid transport across the syncytiotrophoblast microvillous membrane, suggesting that impaired placental amino acid transport does not contribute to reduced birth weight in this high-altitude population.

Body water metabolism in high altitude natives during and after a stay at sea level

1981 ◽  
Vol 25 (1) ◽  
pp. 47-52 ◽  
Author(s):  
S. C. Jain ◽  
Jaya Bardhan ◽  
Y. V. Swamy ◽  
A. Grover ◽  
H. S. Nayar
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Body Water ◽  
Water Metabolism ◽  
High Altitude Natives

scholarly journals Seasonal and Altitudinal Prevalence of Fascioliasis in Buffalo in Eastern Nepal

2018 ◽  
Vol 4 ◽  
pp. 48-53
Author(s):  
Ramesh Prasad Sah ◽  
Hari Kumar Prasai ◽  
Jiban Shrestha ◽  
Md Hasanuzzaman Talukder ◽  
AKM Anisur Rahman ◽  
...  
Keyword(s):  
High Risk ◽  
High Altitude ◽  
Sea Level ◽  
Rainy Season ◽  
Meat Production ◽  
Parasitic Diseases ◽  
Sedimentation Technique ◽  
Risk Period ◽  
Pasture Contamination ◽  
Low Altitude

Buffalo is the most important livestock commodities for milk, meat production and several other multipurpose uses distributed densely from southern tarai to northern mid-hills in Nepal. Among several internal parasitic diseases fascioliasis is highly economic one caused by Fasciola in buffaloes. However, there are only few studies carried on prevalence of fascioliasis emphasizing buffaloes in relation to seasonal (summer and rainy, and winter) and altitudinal variations. Therefore, we examined prevalence of fascioliasis seasonally and vertically. For the purpose, we selected two districts of eastern Nepal and sampled from low altitude area known as Madhesha ranging from 175-200, Dhankuta from 800-1200 m, and Murtidhunga from 1800-2200 m elevation from the sea level, representing tarai, mid hills and high hills, respectively. Altogether from February 2013 to January 2014 at every two months interval we collected 798 fecal samples from buffaloes; 282 from Murtidhunga, 239 from Dhankuta and 277 from Madhesha. The samples were examined microscopically for the presence of Fasciola eggs using sedimentation technique. Results showed that overall prevalence of fascioliasis in buffaloes was 39.9% (319/798), ranging highest 42.6%in Madhesha followed by 39.7% in Murtidhunga and 37.2% in Dhankuta, respectively. The prevalence of fascioliasis was found to be significantly (p <0.05) high in winter (44.9%) comparing to rainy season (34.4%). The prevalence of fascioliasis in buffaloes was relatively higher in low altitude than high altitude, although it was not statistically significant (p <0.05). In our findings the female buffaloes showed higher prevalence for fascioliasis than in male. Since the fascioliasis in buffaloes is highly endemic, thus strategic deworming in high risk period is recommended along with measure to prevent pasture contamination with buffalo feces.

A STUDY OF VARIOUS INDICES OF ADRENOCORTICAL ACTIVITY DURING 23 DAYS AT HIGH ALTITUDE

1963 ◽  
Vol 26 (4) ◽  
pp. 555-566 ◽  
Author(s):  
P. C. B. MACKINNON ◽  
M. E. MONK-JONES ◽  
K. FOTHERBY
Keyword(s):  
Length Of Stay ◽  
High Altitude ◽  
Sea Level ◽  
Acute Exposure ◽  
Adrenocorticotrophic Hormone ◽  
Adrenocortical Activity

SUMMARY 1. Four men and three women ascended by télépherique and helicopter from 1000 to 4333 m. where they remained for 23 days. 2. Measurements of urinary 17-hydroxycorticosteroids, 17-oxosteroids, pregnanediol and pregnanetriol and circulating eosinophils were made at sea level and at high altitude. 3. An attempt was also made to measure changes in emotional activity by means of the palmar sweat index (PSI). This index was assessed at intervals throughout the day at sea level and at high altitude, and in response to adrenocorticotrophic hormone (ACTH) and a self-imposed stress. 4. Within 24 hr. of acute exposure to high altitude urinary 17-hydroxycorticosteroids increased whilst circulating eosinophils decreased; by the 5th day both were returning to sea-level values. The output of 17-oxosteroids was lower by the 5th day at high altitude and subsequently increased; pregnanediol and pregnanetriol levels remained unchanged. 5. PSIs throughout the day become progressively lower as the length of stay at altitude increased. The response to ACTH at sea level and high altitude appeared to be similar but the response to a self-imposed stress was longer in duration at high altitude than at sea level.

Improvement in lung diffusion by endothelin A receptor blockade at high altitude

2012 ◽  
Vol 112 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Claire de Bisschop ◽  
Jean-Benoit Martinot ◽  
Gil Leurquin-Sterk ◽  
Vitalie Faoro ◽  
Hervé Guénard ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Exercise Capacity ◽  
Barometric Pressure ◽  
Membrane Component ◽  
Alveolar Volume ◽  
Double Blind ◽  
Lung Diffusion ◽  
Endothelin A Receptor ◽  
Endothelin A

Lung diffusing capacity has been reported variably in high-altitude newcomers and may be in relation to different pulmonary vascular resistance (PVR). Twenty-two healthy volunteers were investigated at sea level and at 5,050 m before and after random double-blind intake of the endothelin A receptor blocker sitaxsentan (100 mg/day) vs. a placebo during 1 wk. PVR was estimated by Doppler echocardiography, and exercise capacity by maximal oxygen uptake (V̇o2 max). The diffusing capacities for nitric oxide (DLNO) and carbon monoxide (DLCO) were measured using a single-breath method before and 30 min after maximal exercise. The membrane component of DLCO (Dm) and capillary volume (Vc) was calculated with corrections for hemoglobin, alveolar volume, and barometric pressure. Altitude exposure was associated with unchanged DLCO, DLNO, and Dm but a slight decrease in Vc. Exercise at altitude decreased DLNO and Dm. Sitaxsentan intake improved V̇o2 max together with an increase in resting and postexercise DLNO and Dm. Sitaxsentan-induced decrease in PVR was inversely correlated to DLNO. Both DLCO and DLNO were correlated to V̇o2 max at sea level ( r = 0.41–0.42, P < 0.1) and more so at altitude ( r = 0.56–0.59, P < 0.05). Pharmacological pulmonary vasodilation improves the membrane component of lung diffusion in high-altitude newcomers, which may contribute to exercise capacity.

scholarly journals Condensing Life Substances within the House: The Rice-Boiling Shuhi of Southwest China

2017 ◽  
Vol 71 (1) ◽  
Author(s):  
Elisabeth Hsu ◽  
Franz K. Huber ◽  
Caroline S. Weckerle
Keyword(s):  
Tibetan Plateau ◽  
Southeast Asia ◽  
High Altitude ◽  
Sea Level ◽  
Ethnic Groups ◽  
Southwest China ◽  
Cultural Practice ◽  
The Tibetan Plateau ◽  
Regional Culture ◽  
Fault Line

AbstractThe Shuhi of Muli County, Sichuan Province, are one of multiple ethnic groups inhabiting the river gorges of the Qinghai-Gansu-Sichuan corridor between the Tibetan plateau and the Chinese lowlands. The Shuhi have grown paddy rice since times immemorial at an unusually high altitude (ca. 2,300 m above sea level). This article aims to explain this conundrum not merely through the ecology (as is common among Tibetan area specialists), but by researching the cultivation and consumption of rice as a historically-evolved cultural practice. According to a recently formulated agro-archaeological hypothesis regarding the macro-region of Eurasia, it is possible to identify two supra-regional culture complexes distinguished by their respective culinary technologies: rice-boiling versus wheat-grinding-and-baking. The hypothesis posits that the fault line between the two supra-regional cultural complexes is precisely along this river gorges corridor. In this article we provide support for this hypothesis arguing that Shuhi ritual and kinship practices have much affinity with those of other rice-boiling peoples in Southeast Asia, whereas certain of their current religious practices are shared with the wheat-grinding Tibetans.

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