scholarly journals Skeletal muscle quality assessed from echo intensity is associated with muscle strength of middle-aged and elderly persons

2011 ◽  
Vol 112 (4) ◽  
pp. 1519-1525 ◽  
Author(s):  
Yoshihiro Fukumoto ◽  
Tome Ikezoe ◽  
Yosuke Yamada ◽  
Rui Tsukagoshi ◽  
Masatoshi Nakamura ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Muscle Quality ◽  
Elderly Persons ◽  
Echo Intensity ◽  
Middle Aged

scholarly journals Muscle-Skeletal Abnormalities and Muscle Oxygenation during Isokinetic Strength Exercise in Heart Failure with Preserved Ejection Fraction Phenotype: A Cross-Sectional Study

2022 ◽  
Vol 19 (2) ◽  
pp. 709
Author(s):  
Amanda Vale-Lira ◽  
Natália Turri-Silva ◽  
Kenneth Verboven ◽  
João Luiz Quagliotti Durigan ◽  
Alexandra Corrêa de Lima ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Rectus Femoris ◽  
Cross Sectional Study ◽  
Exercise Intolerance ◽  
Strength Exercise ◽  
Echo Intensity ◽  
Sectional Study ◽  
Cross Sectional

Exercise intolerance, a hallmark of patients with heart failure (HF), is associated with muscle weakness. However, its causative microcirculatory and muscle characteristics among those with preserved or reduced ejection fraction (HFpEF or HFrEF) phenotype is unclear. The musculoskeletal abnormalities that could result in impaired peripheral microcirculation are sarcopenia and muscle strength reduction in HF, implying lowered oxidative capacity and perfusion affect transport and oxygen utilization during exercise, an essential task from the microvascular muscle function. Besides that, skeletal muscle microcirculatory abnormalities have also been associated with exercise intolerance in HF patients who also present skeletal muscle myopathy. This cross-sectional study aimed to compare the muscle microcirculation dynamics via near-infrared spectroscopy (NIRS) response during an isokinetic muscle strength test and ultrasound-derived parameters (echo intensity was rectus femoris muscle, while the muscle thickness parameter was measured on rectus femoris and quadriceps femoris) in heart failure patients with HFpEF and HFrEF phenotypes and different functional severities (Weber Class A, B, and C). Twenty-eight aged-matched patients with HFpEF (n = 16) and HFrEF (n = 12) were assessed. We found phenotype differences among those with Weber C severity, with HFrEF patients reaching lower oxyhemoglobin (O2Hb, μM) (−10.9 ± 3.8 vs. −23.7 ± 5.7, p = 0.029) during exercise, while HFpEF reached lower O2Hb during the recovery period (−3.0 ± 3.4 vs. 5.9 ± 2.8, p = 0.007). HFpEF with Weber Class C also presented a higher echo intensity than HFrEF patients (29.7 ± 8.4 vs. 15.1 ± 6.8, p = 0.017) among the ultrasound-derived variables. Our preliminary study revealed more pronounced impairments in local microcirculatory dynamics in HFpEF vs. HFrEF patients during a muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging, which may help explain the commonly observed exercise intolerance in HFpEF patients.

scholarly journals MP397SKELETAL MUSCLE QUALITY AS MEASURED BY ECHO INTENSITY CONTRIBUTES TO THE LOSS OF MUSCLE STRENGTH AND FUNCTION IN PATIENTS WITH NON-DIALYSIS CKD

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i472-i472
Author(s):  
Douglas W. Gould ◽  
Emma L. Watson ◽  
Soteris Xenophontos ◽  
Barbara P. Vogt ◽  
João L. Viana ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Muscle Quality ◽  
Echo Intensity ◽  
And Function

scholarly journals Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals

2021 ◽  
Author(s):  
Małgorzata Kołodziej ◽  
Anna Sebastjan ◽  
Zofia Ignasiak
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Bioelectrical Impedance Analysis ◽  
Skeletal Muscle Mass ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Muscle Quality ◽  
Elderly Persons ◽  
Appendicular Skeletal Muscle ◽  
Appendicular Skeletal Muscle Mass

Abstract Background and aim The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Methods One-thousand-and-fifteen subjectively healthy persons aged 60–87 years were tested. Anthropometric measurements and physical fitness and activity measurements were carried out and the frailty phenotype was evaluated. Appendicular skeletal muscle mass was estimated using the bioelectrical impedance analysis method. Muscle quality was assessed through an index correcting strength relative to muscle mass and through the impedance phase angle. The correlation between the muscle mass and quality estimating parameters and the probability of identifying pre-frailty was checked using multiple logistic regression. Results The prevalence of pre-frailty was 38%. The pre-frail persons were found to have a significantly lower muscle mass and quality than the non-frail persons, with the difference in the case of the muscle quality index nearly twice larger than for the muscle mass index. A significant logit model was obtained for pre-frailty prevalence, which was strongly dependent on the appendicular skeletal muscle mass (adjusted odds ratio (OR): 0.43, 95% CI 0.36–0.52, p < 0.001) and functional quality (adjusted OR: 0.26, 95% CI 0.18–0.38, p < 0.001) and less on age (adjusted OR: 1.10, 95% CI 1.07–1.13, p < 0.001). Conclusion The strong correlation between the frailty phenotype and appendicular skeletal muscle mass and functional quality suggests that the two variables should be included in routine geriatric assessment with regard to frailty.

scholarly journals Declines in skeletal muscle quality vs. size following two weeks of knee joint immobilization

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e8224 ◽  
Author(s):  
Rob J. MacLennan ◽  
Michael Sahebi ◽  
Nathan Becker ◽  
Ethan Davis ◽  
Jeanette M. Garcia ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Knee Joint ◽  
Vastus Lateralis ◽  
Rectus Femoris ◽  
Cross Sectional Area ◽  
Muscle Quality ◽  
Muscle Size ◽  
Sectional Area ◽  
Echo Intensity ◽  
Cross Sectional

Background Disuse of a muscle group, which occurs during bedrest, spaceflight, and limb immobilization, results in atrophy. It is unclear, however, if the magnitude of decline in skeletal muscle quality is similar to that for muscle size. The purpose of this study was to examine the effects of two weeks of knee joint immobilization on vastus lateralis and rectus femoris echo intensity and cross-sectional area. Methods Thirteen females (mean ± SD age = 21 ± 2 years) underwent two weeks of left knee joint immobilization via ambulating on crutches and use of a brace. B-mode ultrasonography was utilized to obtain transverse plane images of the immobilized and control vastus lateralis and rectus femoris at pretest and following immobilization. Effect size statistics and two-way repeated measures analyses of variance were used to interpret the data. Results No meaningful changes were demonstrated for the control limb and the rectus femoris of the immobilized limb. Analyses showed a large increase in vastus lateralis echo intensity (i.e., decreased muscle quality) for the immobilized limb (p = .006, Cohen’s d = .918). For vastus lateralis cross-sectional area, no time × limb interaction was observed (p = .103), but the effect size was moderate (d = .570). There was a significant association between the increase in vastus lateralis echo intensity and the decrease in cross-sectional area (r =  − .649, p = .016). Conclusion In female participants, two weeks of knee joint immobilization resulted in greater deterioration of muscle quality than muscle size. Echo intensity appears to be an attractive clinical tool for monitoring muscle quality during disuse.

Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial

2009 ◽  
Vol 107 (6) ◽  
pp. 1864-1873 ◽  
Author(s):  
Sonja Kukuljan ◽  
Caryl A. Nowson ◽  
Kerrie Sanders ◽  
Robin M. Daly
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Muscle Mass ◽  
Quantitative Computed Tomography ◽  
Older Men ◽  
Muscle Size ◽  
Middle Aged ◽  
Low Fat ◽  
Fortified Milk ◽  
Total Body

Limited data have suggested that the consumption of fluid milk after resistance training (RT) may promote skeletal muscle hypertrophy. The aim of this study was to assess whether a milk-based nutritional supplement could enhance the effects of RT on muscle mass, size, strength, and function in middle-aged and older men. This was an 18-mo factorial design (randomized control trial) in which 180 healthy men aged 50–79 yr were allocated to the following groups: 1) exercise + fortified milk, 2) exercise, 3) fortified milk, or 4) control. Exercise consisted of progressive RT with weight-bearing impact exercise. Men assigned to the fortified milk consumed 400 ml/day of low-fat milk, providing an additional 836 kJ, 1000 mg calcium, 800 IU vitamin D3, and 13.2 g protein per day. Total body lean mass (LM) and fat mass (FM) (dual-energy X-ray absorptiometry), midfemur muscle cross-sectional area (CSA) (quantitative computed tomography), muscle strength, and physical function were assessed. After 18 mo, there was no significant exercise by fortified milk interaction for total body LM, muscle CSA, or any functional measure. However, main effect analyses revealed that exercise significantly improved muscle strength (∼20–52%, P < 0.001), LM (0.6 kg, P < 0.05), FM (−1.1 kg, P < 0.001), muscle CSA (1.8%, P < 0.001), and gait speed (11%, P < 0.05) relative to no exercise. There were no effects of the fortified milk on muscle size, strength, or function. In conclusion, the daily consumption of low-fat fortified milk does not enhance the effects of RT on skeletal muscle size, strength, or function in healthy middle-aged and older men with adequate energy and nutrient intakes.

CONTRIBUTION OF PROTEIN INTAKE AND CONCURRENT EXERCISE TO SKELETAL MUSCLE QUALITY WITH AGING

2019 ◽  
pp. 1-6
Author(s):  
N.D. Dicks ◽  
C.J. Kotarsky ◽  
K.A. Trautman ◽  
A.M. Barry ◽  
J.F. Keith ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
Protein Intake ◽  
Muscle Quality ◽  
Resonance Imaging ◽  
Middle Aged ◽  
Light Physical Activity ◽  
Cross Sectional ◽  
Concurrent Exercise ◽  
Magnetic Resonance Imaging Mri

Background: The use of magnetic resonance imaging (MRI) derived functional cross-sectional area (FCSA) and intramuscular adipose tissue (IMAT) to define skeletal muscle quality is of fundamental importance in order to understand aging and inactivity-related loss of muscle mass. Objectives: This study examined factors associated with lower-extremity skeletal muscle quality in healthy, younger, and middle-aged adults. Design: Cross-sectional study. Setting and Participants: Ninety-eight participants (53% female) were classified as younger (20-35 years, n=50) or middle-aged (50-65 years, n=48) as well as sedentary (≤1 day per week) or active (≥3 days per week) on self-reported concurrent exercise (aerobic and resistance). Measurements: All participants wore an accelerometer for seven days, recorded a three-day food diary, and participated in magnetic resonance imaging (MRI) of the lower limbs. Muscle cross-sectional area (CSA) was determined by tracing the knee extensors (KE) and plantar flexors, while muscle quality was established through the determination of FCSA and IMAT via color thresholding. Results: One-way analysis of variance and stepwise regression models were performed to predict FCSA and IMAT. KE-IMAT (cm2) was significantly higher among sedentary (3.74 ± 1.93) vs. active (1.85 ± 0.56) and middle-aged (3.14 ± 2.05) vs. younger (2.74 ± 1.25) (p < 0.05). Protein intake (g•kg•day-1) was significantly higher in active (1.63 ± 0.55) vs. sedentary (1.19 ± 0.40) (p < 0.05). Sex, age, concurrent exercise training status, and protein intake were significant predictors of KE FCSA (R2 = 0.71, p < 0.01), while concurrent exercise training status and light physical activity predicted 33% of the variance in KE IMAT (p < 0.01). Conclusion: Concurrent exercise training, dietary protein intake, and light physical activity are significant determinants of skeletal muscle health and require further investigation to mitigate aging and inactivity-related loss of muscle quality.

scholarly journals Aging‐related loss of skeletal muscle strength: the role of muscle quality (863.8)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Sebastien Barbat‐Artigas ◽  
Charlotte Pion ◽  
Gilles Gouspillou ◽  
Marc Belanger ◽  
Russell Hepple ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Muscle Quality ◽  
Skeletal Muscle Strength

scholarly journals Skeletal Muscle Quality Of Nonagenarians And Centenarians

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 825-825
Author(s):  
Iva Miljkovic ◽  
Adam Sterczala ◽  
Emma Barinas-Mitchell ◽  
Ryan Cvejkus ◽  
Mary Feitosa ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fiber Type ◽  
Oldest Old ◽  
Age Groups ◽  
Rectus Femoris ◽  
Muscle Quality ◽  
Echo Intensity ◽  
Physically Active ◽  
Muscle Adiposity ◽  
And Function

Abstract Skeletal muscle adipose tissue infiltration is hypothesized to lead to poorer muscle quality and function with aging. Indeed, skeletal muscle adiposity has emerged as a consistent, independent predictor of skeletal muscle strength, mobility, metabolic disorders, and survival among older adults. However, phenotypic features of skeletal muscle among the oldest-old remain poorly characterized. Herein, we evaluated the skeletal muscle characteristics of 54 nonagenarians and centenarians (mean age 98 years, range 90-110 years; 63% women) and 25 middle-aged individuals (mean age 54 years, range 40-59 years; 36% women) belonging to the Long Life Family Study (LLFS), an international, multicenter cohort of families with a clustering of longevity. Ultrasonography was used to measure echo intensity of the sternocleidomastoid muscle, which has a similar fiber type distribution to the rectus femoris. Greater echo intensity is indicative of lower muscle quality (greater adipose and fibrotic tissue). Current smoking, alcohol intake, and BMI were similar between the age groups. Nonagenarians and centenarians had lower grip strength (16.3 vs. 39 kg) and were less physically active (22.2% vs 66.7% exercised 1+ times per week) compared to younger individuals (P&lt;0.001 for all). Mean±SE echo intensity, adjusted for gender, field center, BMI and physical activity was 52.1±1.7 among nonagenarians and centenarians compared to 44.2±2.4 among younger individuals (P=0.0098). Our preliminary findings suggest that nonagenarians and centenarians may have substantially lower skeletal muscle quality and strength compared to their younger aged counterparts. Additional research is needed to better understand the mechanisms leading to poorer muscle characteristics of the oldest-old.

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