Molecular pattern of ductal pancreatic cancer

1998 ◽  
Vol 383 (2) ◽  
pp. 105 ◽  
Author(s):  
V. Sirivatanauksorn ◽  
Y. Sirivatanauksorn ◽  
N. R. Lemoine
Keyword(s):  
Pancreatic Cancer ◽  
Molecular Pattern ◽  
Ductal Pancreatic Cancer

scholarly journals Promoting Effect of a High-Fat/High-Protein Diet in DMBA-Induced Ductal Pancreatic Cancer in Rats

2001 ◽  
Vol 233 (5) ◽  
pp. 688-695 ◽  
Author(s):  
Kaspar Z’graggen ◽  
Andrew L. Warshaw ◽  
Jens Werner ◽  
Fiona Graeme-Cook ◽  
Ramon E. Jimenez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat ◽  
Promoting Effect ◽  
Ductal Pancreatic Cancer

scholarly journals The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 536
Author(s):  
Katarzyna Malarz ◽  
Jacek Mularski ◽  
Marcin Pacholczyk ◽  
Robert Musiol
Keyword(s):  
Pancreatic Cancer ◽  
Bile Duct ◽  
Kinase Activity ◽  
Lung Cancers ◽  
Normal Product ◽  
Idh1 R132h ◽  
Wide Range ◽  
Receptor Kinases ◽  
The Status ◽  
Ductal Pancreatic Cancer

Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases are often found in leukemias, glioblastomas, lung cancers, and ductal pancreatic cancer among others. Mutation R132H, which changes the functionality of an enzyme to produce mutagenic 2-hydroxyglutarate instead of a normal product, is particularly important in this field. A series of inhibitors were described for these enzymes of which ivosidenib was the first to be approved for treating leukemia and bile duct cancers in 2018. Here, we investigated the polypharmacological landscape of the activity for known sulfamoyl derivatives that are inhibitors, which are selective towards IDH1 R132H. These compounds appeared to be effective inhibitors of several non-receptor kinases at a similar level as imatinib and axitinib. The antiproliferative activity of these compounds against a panel of cancer cells was tested and is explained based on the relative expression levels of the investigated proteins. The multitargeted activity of these compounds makes them valuable agents against a wide range of cancers, regardless of the status of IDH1.

scholarly journals Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Cancer Cell ◽  
2003 ◽  
Vol 4 (6) ◽  
pp. 437-450 ◽  
Author(s):  
Sunil R. Hingorani ◽  
Emanuel F. Petricoin ◽  
Anirban Maitra ◽  
Vinodh Rajapakse ◽  
Catrina King ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Early Detection ◽  
Ductal Pancreatic Cancer

Molecular Understanding of Development of Ductal Pancreatic Cancer

The Pancreas ◽  
2018 ◽  
pp. 679-687
Author(s):  
Laura D. Wood ◽  
Ralph H. Hruban
Keyword(s):  
Pancreatic Cancer ◽  
Ductal Pancreatic Cancer

The value of intraoperative washing cytology for invasive ductal pancreatic cancer

Pancreatology ◽  
2016 ◽  
Vol 16 (4) ◽  
pp. S155
Author(s):  
Yusuke Kyoden ◽  
Noriyuki Oba ◽  
Hideyuki Kanemoto ◽  
Michiro Takahashi ◽  
Masakazu Takagi
Keyword(s):  
Pancreatic Cancer ◽  
Ductal Pancreatic Cancer
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