scholarly journals The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 536
Author(s):  
Katarzyna Malarz ◽  
Jacek Mularski ◽  
Marcin Pacholczyk ◽  
Robert Musiol
Keyword(s):  
Pancreatic Cancer ◽  
Bile Duct ◽  
Kinase Activity ◽  
Lung Cancers ◽  
Normal Product ◽  
Idh1 R132h ◽  
Wide Range ◽  
Receptor Kinases ◽  
The Status ◽  
Ductal Pancreatic Cancer

Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases are often found in leukemias, glioblastomas, lung cancers, and ductal pancreatic cancer among others. Mutation R132H, which changes the functionality of an enzyme to produce mutagenic 2-hydroxyglutarate instead of a normal product, is particularly important in this field. A series of inhibitors were described for these enzymes of which ivosidenib was the first to be approved for treating leukemia and bile duct cancers in 2018. Here, we investigated the polypharmacological landscape of the activity for known sulfamoyl derivatives that are inhibitors, which are selective towards IDH1 R132H. These compounds appeared to be effective inhibitors of several non-receptor kinases at a similar level as imatinib and axitinib. The antiproliferative activity of these compounds against a panel of cancer cells was tested and is explained based on the relative expression levels of the investigated proteins. The multitargeted activity of these compounds makes them valuable agents against a wide range of cancers, regardless of the status of IDH1.

РУССКИЙ ЯЗЫК – ЯЗЫК ВЫСШЕГО ОБРАЗОВАНИЯ В КГМА

2020 ◽  
pp. 50-53
Author(s):  
Г. Кульбаева
Keyword(s):  
Russian Language ◽  
Educational Activity ◽  
Official Language ◽  
Main Motivation ◽  
Language Functioning ◽  
Teaching Language ◽  
Medical Academy ◽  
Wide Range ◽  
The Status ◽  
The Russian Language

Аннотация. В статье рассматривается вопрос о функционировании русского языка в образовательном пространстве КГМА. Большое место в работе занимает роль русского языка в учебной деятельности студентов-медиков. Мотивацией к изучению именно, русского языка являются следующие факторы: статус официального языка; возможность привлечь внимание широкого круга специалистов к своим исследованиям; понимание престижности русского языка. В статье нашли отражение различные формы работы по расширению сферы использования русского языка в медицинской академии. В работе уделено внимание и профильным учебным пособиям, разработанным автором статьи. Анализ некоторых заданий позволяет констатировать тот факт, что содержание пособии определено через компетенции, одной из которых является языковая. Ключевые слова:язык обучения, фундаментальные науки, соматические ФЕ, компетентностная основа, профессиональная направленность, жаргонная лексика. Аннотация. Макалада КММАнын билим берүү мейкиндеги орус тилин өздөштүү маселеси каралат. Орус тили студент-медиктердин окуу ишмердигинде чоң роль ойнойт. Расмий тил статусу, өз изилдөөлөрүнө көпчүлүк адистердин көңүлүн буруу мүмкүнчүлүгү, орус тилинин баркын түшүнүү, өзгөчөлөп билүүгө далил болуп эсептелет. Макалада медициналык академияда орус тили колдонуу чөйрөсүн кеңейтүү боюнча иштөөнү ар кандай формалары көрсөтүлгөн. Эмгекте макаланын автору иштеп чыккан адистик окуу колдонмолорго да көңул бурулган. Кээ бир тапшырмалардын анализи колдонмонун мазмуну компетенция, анын бирөөсү тил аркылуу аныкталганын факт катары көрсөтүүгө мүмкүндүк түзөт. Түйүндүү сөздөр: фундаменталдык илимдер, соматикалык фразеологизмдер, компетенттик негиз, профессионалдык багытталыш, жаргондук лексика. Summary. The article discusses the Russian language functioning in the of the KSMA’s educational space. Russian language plays a big role in the educational activity of the medical students. The main motivation of learning the Russian language has the following points: the status of the official language; the opportunity to attract the attention of a wide range of specialists to their research; understanding of the prestige of the Russian language. The article reflected various forms of work to expand the scope of the use of the Russian language at the medical academy. The work focuses on specialized textbooks developed by the author of the article. An analysis of some tasks allows us to state the fact that the content of the manual is determined through competencies, one of which is the language. Key words: teaching language, fundamental sciences, somatic phraseological unit, slang vocabulary.

Recycling and Reuse in the Roman Economy

2020 ◽  
Keyword(s):  
Building Materials ◽  
Computational Modelling ◽  
Late Antique ◽  
Roman Economy ◽  
Wide Range ◽  
The Status ◽  
Recent Developments ◽  
Methodological Approaches ◽  
First Time ◽  
Site Types

The recycling and reuse of materials and objects were extensive in the past, but have rarely been embedded into models of the economy; even more rarely has any attempt been made to assess the scale of these practices. Recent developments, including the use of large datasets, computational modelling, and high-resolution analytical chemistry, are increasingly offering the means to reconstruct recycling and reuse, and even to approach the thorny matter of quantification. Growing scholarly interest in the topic has also led to an increasing recognition of these practices from those employing more traditional methodological approaches, which are sometimes coupled with innovative archaeological theory. Thanks to these efforts, it has been possible for the first time in this volume to draw together archaeological case studies on the recycling and reuse of a wide range of materials, from papyri and textiles, to amphorae, metals and glass, building materials and statuary. Recycling and reuse occur at a range of site types, and often in contexts which cross-cut material categories, or move from one object category to another. The volume focuses principally on the Roman Imperial and late antique world, over a broad geographical span ranging from Britain to North Africa and the East Mediterranean. Last, but not least, the volume is unique in focusing upon these activities as a part of the status quo, and not just as a response to crisis.

scholarly journals Atmospheric Pressure Plasma Deposition of TiO2: A Review

Materials ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 2931
Author(s):  
Soumya Banerjee ◽  
Ek Adhikari ◽  
Pitambar Sapkota ◽  
Amal Sebastian ◽  
Sylwia Ptasinska
Keyword(s):  
Atmospheric Pressure ◽  
Gas Flow ◽  
Plasma Deposition ◽  
Atmospheric Pressure Plasma ◽  
Cost Savings ◽  
Historical Background ◽  
Pressure Plasma ◽  
Wide Range ◽  
The Status ◽  
Deposition Techniques

Atmospheric pressure plasma (APP) deposition techniques are useful today because of their simplicity and their time and cost savings, particularly for growth of oxide films. Among the oxide materials, titanium dioxide (TiO2) has a wide range of applications in electronics, solar cells, and photocatalysis, which has made it an extremely popular research topic for decades. Here, we provide an overview of non-thermal APP deposition techniques for TiO2 thin film, some historical background, and some very recent findings and developments. First, we define non-thermal plasma, and then we describe the advantages of APP deposition. In addition, we explain the importance of TiO2 and then describe briefly the three deposition techniques used to date. We also compare the structural, electronic, and optical properties of TiO2 films deposited by different APP methods. Lastly, we examine the status of current research related to the effects of such deposition parameters as plasma power, feed gas, bias voltage, gas flow rate, and substrate temperature on the deposition rate, crystal phase, and other film properties. The examples given cover the most common APP deposition techniques for TiO2 growth to understand their advantages for specific applications. In addition, we discuss the important challenges that APP deposition is facing in this rapidly growing field.

scholarly journals Key Challenges in the Status Analysis for the Sustainable Urban Mobility Plan in Podgorica, Montenegro

2021 ◽  
Vol 13 (3) ◽  
pp. 1037
Author(s):  
Radoje Vujadinović ◽  
Jelena Šaković Jovanović ◽  
Aljaž Plevnik ◽  
Luka Mladenovič ◽  
Tom Rye
Keyword(s):  
Traffic Accidents ◽  
Road Traffic ◽  
Motor Vehicles ◽  
Urban Mobility ◽  
Passenger Cars ◽  
Study Program ◽  
Wide Range ◽  
The Status ◽  
Sustainable Urban Mobility ◽  
Status Analysis

The paper presents the results of the application of a practical approach for collecting data, which provides a simple, cost efficient, and easily reproducible method that was applied to obtain the necessary data for the status analysis of the Sustainable Urban Mobility Plan (SUMP) for Podgorica, the capital of Montenegro. Important data for the estimation of the existing condition of the traffic system were collected through desk research from the appropriate institutions and organizations. Several surveys and focus group interviews were conducted, in which about 5000 residents of Podgorica participated. In addition to answering questions, residents made numerous suggestions, confirming the correctness of a participatory approach in the new traffic planning paradigm that provides the SUMP with crucial advantages. A manual cordon count of traffic on five bridges for the traffic of the motor vehicles, as well as on two pedestrian-only bridges, was performed by students from the study program Road Traffic, and there are plans to repeat this in the coming years in order to enable more reliable monitoring and evaluation of the obtained data. Contemporary quality management tools such as BYPAD and ParkPAD were also used to assess the status of cycling and parking policy, respectively. It is especially important to emphasize that Podgorica is the first city in the West Balkans, and the fourth city in Europe, in which the ParkPAD tool was applied. A wide range of negative phenomena and trends was identified, like a rapid increase in the number of registered vehicles, an increase in the motorization rate and the number of traffic accidents, increased non-compliance with traffic rules, excessive use of passenger cars and auto-taxi vehicles, insufficient use of unattractive public transport, walking and cycling, etc. Based on the data collected, key challenges in status analysis in Podgorica were identified, which the SUMP should try to overcome.

scholarly journals Therapeutic Application of Monoclonal Antibodies in Pancreatic Cancer: Advances, Challenges and Future Opportunities

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1781
Author(s):  
Gustavo A. Arias-Pinilla ◽  
Helmout Modjtahedi
Keyword(s):  
Pancreatic Cancer ◽  
Monoclonal Antibodies ◽  
Antibody Therapy ◽  
Therapeutic Targets ◽  
Poor Response ◽  
Therapeutic Agents ◽  
Therapeutic Interventions ◽  
Western World ◽  
Wide Range ◽  
Novel Therapeutic

Pancreatic cancer remains as one of the most aggressive cancer types. In the absence of reliable biomarkers for its early detection and more effective therapeutic interventions, pancreatic cancer is projected to become the second leading cause of cancer death in the Western world in the next decade. Therefore, it is essential to discover novel therapeutic targets and to develop more effective and pancreatic cancer-specific therapeutic agents. To date, 45 monoclonal antibodies (mAbs) have been approved for the treatment of patients with a wide range of cancers; however, none has yet been approved for pancreatic cancer. In this comprehensive review, we discuss the FDA approved anticancer mAb-based drugs, the results of preclinical studies and clinical trials with mAbs in pancreatic cancer and the factors contributing to the poor response to antibody therapy (e.g. tumour heterogeneity, desmoplastic stroma). MAb technology is an excellent tool for studying the complex biology of pancreatic cancer, to discover novel therapeutic targets and to develop various forms of antibody-based therapeutic agents and companion diagnostic tests for the selection of patients who are more likely to benefit from such therapy. These should result in the approval and routine use of antibody-based agents for the treatment of pancreatic cancer patients in the future.

scholarly journals Teaching Critical Vocabulary to Filipino Heritage Language Learners

2021 ◽  
Vol 11 (6) ◽  
pp. 260
Author(s):  
Jayson Parba
Keyword(s):  
Language Development ◽  
Social Issues ◽  
Language Teaching ◽  
Language Teachers ◽  
World Language ◽  
Wide Range ◽  
Teachers And Students ◽  
The Status ◽  
Language Classrooms ◽  
L1 And L2

Engaging in critical dialogues in language classrooms that draw on critical pedagogical perspectives can be challenging for learners because of gaps in communicative resources in their L1 and L2. Since critically oriented classrooms involve discussing social issues, students are expected to deploy “literate talk” to engage in critiquing society and a wide range of texts. Although recent studies have explored teachers’ and students’ engagement with critical materials and critical dialogues, research that explores language development in critical language teaching remains a concern for language teachers. In this paper, I share my experience of fostering language development, specifically the overt teaching of critical vocabulary to students of (Tagalog-based) Filipino language at a university in Hawai’i. Through a discussion of racist stereotypes targeting Filipinos and the impacts of these discourses on students’ lived experiences, the notion of “critical vocabulary” emerges as an important tool for students to articulate the presence of and to dismantle oppressive structures of power, including everyday discourses supporting the status quo. This paper defines critical vocabulary and advances its theoretical and practical contribution to critical language teaching. It also includes students’ perspectives of their language development and ends with pedagogical implications for heritage/world language teachers around the world.

The Study of Hindu New Religious Movements

2011 ◽  
Vol 15 (2) ◽  
pp. 6-19
Author(s):  
Gene R. Thursby
Keyword(s):  
Transcendental Meditation ◽  
Social World ◽  
Religious Movements ◽  
New Religious Movements ◽  
Special Issue ◽  
Social Harmony ◽  
Wide Range ◽  
The World ◽  
The Status ◽  
Arya Samaj

The category of Hindu new religious movements is conventional and useful, but has imprecise boundaries. Scholars tend to include within it some groups that have claimed they are not Hindu (Arya Samaj, Ramakrishna Mission) or not religious (Transcendental Meditation). Within its wide range are world-affirming groups dedicated to transforming the physical and social world as well as world-transcending groups that find the status of the world doubtful and their purpose at another level or in another realm. The four articles in this special issue of Nova Religio on Hindu new religious movements represent several aspects of this category, and the potential for accommodation of basic differences, social harmony, and even world-transcendence.

SiC Semiconductor Applications - An Air Force Perspective

1996 ◽  
Vol 423 ◽  
Author(s):  
L. S. Rea
Keyword(s):  
Air Force ◽  
Device Performance ◽  
Full Potential ◽  
Materials Development ◽  
Device Development ◽  
Performance Requirements ◽  
Wide Range ◽  
The Status ◽  
Performance Results ◽  
High Temperature Electronic

AbstractThe Department of Defense (DoD) is investing in the development of Silicon Carbide (SiC) for a wide range of applications. Over the past year, SiC technology has demonstrated excellent device performance results for power devices, high temperature electronic devices and microwave devices. The materials growth and processing technology for SiC is now at a level of sufficient maturity to support substantial device development efforts. While there is still considerable materials and device research required for SiC to achieve it's full potential, the fundamental technology has been proven for several critical applications. A perspective on some Air Force device performance requirements will be presented. The status of SiC materials development, material limits to advances in device performance and issues relating to supporting technology will also be discussed.

scholarly journals Speech genre theory through the prism of modern linguistics

2021 ◽  
Vol 29 (1) ◽  
pp. 6-11
Author(s):  
Valentina A. Maslova ◽  
Keyword(s):  
Speech Acts ◽  
Modern Science ◽  
Personal Communication ◽  
Genre Theory ◽  
Modern Culture ◽  
Wide Range ◽  
The Status ◽  
Research Problems ◽  
Important Trend ◽  
Object Of Study

The article deals with the status of the speech genres theory (SGT) and its contribution to the development of modern linguistics. In his polemical article Professor V. V. Dementyev argues that SGT is characterized by the wide range of research problems, a close connection with such academic domains as the theory of speech acts, colloquial studies, discourse analysis, linguistic personology and other areas that study a human and their language. This thesis does not raise objections, as the 21st century is considered to be the century of syncretism and interpenetration of sciences, which has become one of the main features of the entire post-non-classical science. This approach provides a holistic reflection on the object of study, in this case, on the language. It is called syncretism, integrity, interdisciplinarity, polydisciplinarity, transdisciplinarity. In general, these terms are synonymous, because they are based on the idea of holism of everything in the world. In this sense, SGT is in line with modern science. The thesis of V. V. Dementyev on the diffusion of genres. Diffusion can be considered as the most important trend not only in science, but also in the entire modern culture, which is shown with the help of examples. However, some statements of V. V. Dementyev’s article seem debatable: the problem of the pervasiveness of SGT in linguistics in its entirety, which can give rise to a dangerous tendency – the absorption of linguistics by SGT. Their interests do often overlap, but each of the named areas solves the problem of personal communication in a social environment in its own way, and each of them has its own subject and its own history. Today SGT cannot take into account many of the processes occurring in discourse, but this is a relatively new science with a great future.

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