Toll-like receptor 2 mediates vascular contraction and activates RhoA signaling in vascular smooth muscle cells from STZ-induced type 1 diabetic rats

2015 ◽  
Vol 467 (11) ◽  
pp. 2361-2374 ◽  
Author(s):  
Luke Schmidt ◽  
Maria Alicia Carrillo-Sepulveda
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Diabetic Rats ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Rhoa Signaling

scholarly journals EBP50 inhibits the anti-mitogenic action of the parathyroid hormone type 1 receptor in vascular smooth muscle cells

2010 ◽  
Vol 49 (6) ◽  
pp. 1012-1021 ◽  
Author(s):  
Gyun Jee Song ◽  
Stacey Barrick ◽  
Kristen L. Leslie ◽  
Brian Sicari ◽  
Nathalie M. Fiaschi-Taesch ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Parathyroid Hormone ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Mitogenic Action

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats

2000 ◽  
Vol 278 (3) ◽  
pp. H714-H722 ◽  
Author(s):  
Rui Wang ◽  
Yuejin Wu ◽  
Guanghua Tang ◽  
Lingyun Wu ◽  
Salma Toma Hanna
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Vascular Complications ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
High Concentration ◽  
Voltage Dependent

Vascular complications of diabetes are associated with abnormal Ca2+ handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltage-dependent Ca2+ channel (VDCC) currents may play an important role. In the present study, the characteristics of L-type VDCC currents in tail artery SMCs from streptozotocin-induced diabetic rats were examined. The densities, but not the voltage dependence, of L-type VDCC currents were reduced as diabetes progressed from 1 wk to 3 mo. The inhibitory effect of dibutyryl-cAMP on L-type VDCC currents was greater in diabetic SMCs than in age-matched control cells ( P < 0.01). Both the stimulatory effect of BAY K 8644 and the inhibitory effect of nifedipine on L-type VDCC currents were significantly enhanced in diabetic cells. The diabetes-related abnormalities in L-type VDCC currents were mimicked by culturing SMCs with a high concentration of glucose. Our results suggest that the properties of L-type VDCC in diabetic vascular SMCs were significantly altered, partially related to the increased L-type VDCC sensitivity to cAMP and hyperglycemia.

scholarly journals Downregulation of Angiotensin II Type 1 Receptor by All- trans Retinoic Acid in Vascular Smooth Muscle Cells

Hypertension ◽  
2000 ◽  
Vol 35 (1) ◽  
pp. 297-302 ◽  
Author(s):  
Kotaro Takeda ◽  
Toshihiro Ichiki ◽  
Yuko Funakoshi ◽  
Kiyoko Ito ◽  
Akira Takeshita
Keyword(s):  
Smooth Muscle ◽  
Retinoic Acid ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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