In-vitro germination and growth of lily pollen tubes is affected by protein phosphatase inhibitors

Planta ◽  
1998 ◽  
Vol 207 (2) ◽  
pp. 303-312 ◽  
Author(s):  
Gerhard Obermeyer ◽  
Hildegard Klaushofer ◽  
Marion Nagl ◽  
Margit Höftberger ◽  
Friedrich-Wilhelm Bentrup
Keyword(s):  
Protein Phosphatase ◽  
Pollen Tubes ◽  
In Vitro Germination ◽  
Phosphatase Inhibitors ◽  
Lily Pollen ◽  
Protein Phosphatase Inhibitors ◽  
Germination And Growth

In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts

1990 ◽  
Vol 171 (2) ◽  
pp. 867-874 ◽  
Author(s):  
Rie Matsushima ◽  
Shigeru Yoshizawa ◽  
Mariyo F. Watanabe ◽  
Ken-ichi Harada ◽  
Mitsuru Furusawa ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Mouse Skin ◽  
Phosphatase Inhibitors ◽  
Protein Phosphatase Inhibitors ◽  
In Vivo Effects

Effects of Serine/Threonine Protein Phosphatases on Ion Channels in Excitable Membranes

2000 ◽  
Vol 80 (1) ◽  
pp. 173-210 ◽  
Author(s):  
Stefan Herzig ◽  
Joachim Neumann
Keyword(s):  
Ion Channels ◽  
Protein Phosphatase ◽  
Protein Phosphatases ◽  
Direct Interaction ◽  
Specific Protein ◽  
Biochemical Properties ◽  
Future Research ◽  
Regulatory Subunits ◽  
Phosphatase Inhibitors ◽  
Protein Phosphatase Inhibitors

This review deals with the influence of serine/threonine-specific protein phosphatases on the function of ion channels in the plasma membrane of excitable tissues. Particular focus is given to developments of the past decade. Most of the electrophysiological experiments have been performed with protein phosphatase inhibitors. Therefore, a synopsis is required incorporating issues from biochemistry, pharmacology, and electrophysiology. First, we summarize the structural and biochemical properties of protein phosphatase (types 1, 2A, 2B, 2C, and 3–7) catalytic subunits and their regulatory subunits. Then the available pharmacological tools (protein inhibitors, nonprotein inhibitors, and activators) are introduced. The use of these inhibitors is discussed based on their biochemical selectivity and a number of methodological caveats. The next section reviews the effects of these tools on various classes of ion channels (i.e., voltage-gated Ca2+ and Na+ channels, various K+ channels, ligand-gated channels, and anion channels). We delineate in which cases a direct interaction between a protein phosphatase and a given channel has been proven and where a more complex regulation is likely involved. Finally, we present ideas for future research and possible pathophysiological implications.

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