scholarly journals Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults

2015 ◽  
Vol 221 (8) ◽  
pp. 3891-3901 ◽  
Author(s):  
Jiayuan Xu ◽  
Wen Qin ◽  
Bing Liu ◽  
Tianzi Jiang ◽  
Chunshui Yu
Keyword(s):  
Young Adults ◽  
Functional Connectivity ◽  
Gray Matter ◽  
Resting State ◽  
Genetic Variants ◽  
Gray Matter Volume ◽  
Resting State Functional Connectivity ◽  
Dopamine System ◽  
Matter Volume

scholarly journals The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus

2019 ◽  
Vol 44 (5) ◽  
pp. 1097-1107 ◽  
Author(s):  
Thang M. Le ◽  
Ding-Lieh Liao ◽  
Jaime Ide ◽  
Sheng Zhang ◽  
Simon Zhornitsky ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Functional Connectivity ◽  
Body Mass ◽  
Gray Matter ◽  
Resting State ◽  
Gray Matter Volume ◽  
Resting State Functional Connectivity ◽  
Matter Volume

Abnormal gray matter volume and resting-state functional connectivity in former heroin-dependent individuals abstinent for multiple years

2015 ◽  
Vol 21 (3) ◽  
pp. 646-656 ◽  
Author(s):  
Lubin Wang ◽  
Feng Zou ◽  
Tianye Zhai ◽  
Yu Lei ◽  
Shuwen Tan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Gray Matter ◽  
Resting State ◽  
Gray Matter Volume ◽  
Resting State Functional Connectivity ◽  
Matter Volume

scholarly journals Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haixia Zheng ◽  
Bart N. Ford ◽  
Rayus Kuplicki ◽  
Kaiping Burrows ◽  
Peter W. Hunt ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter ◽  
Resting State ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Affective Processing ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Matter Volume

AbstractHuman cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported a reduction in the gray matter volume (GMV) of several brain regions in two independent samples of participants who were seropositive for HCMV (HCMV+) compared to matched participants who were seronegative for HCMV (HCMV−). In addition to an independent replication of the GMV findings, this study aimed to examine whether HCMV+ was associated with differences in resting-state functional connectivity (rsfMRI-FC). After balancing on 11 clinical/demographic variables using inverse probability of treatment weighting (IPTW), GMV and rsfMRI-FC were obtained from 99 participants with major depressive disorder (MDD) who were classified into 42 HCMV+ and 57 HCMV− individuals. Relative to the HCMV− group, the HCMV+ group showed a significant reduction of GMV in nine cortical regions. Volume reduction in the right lateral orbitofrontal cortex (standardized beta coefficient (SBC) = −0.32, [95%CI, −0.62 to −0.02]) and the left pars orbitalis (SBC = −0.34, [95%CI, −0.63 to −0.05]) in the HCMV+ group was also observed in the previous study. Regardless of the parcellation method or analytical approach, relative to the HCMV− group, the HCMV+ group showed hypoconnectivity between the hubs of the sensorimotor network (bilateral postcentral gyrus) and the hubs of the salience network (bilateral insula) with effect sizes ranging from SBC = −0.57 to −0.99. These findings support the hypothesis that a positive HCMV serostatus is associated with altered connectivity of regions that are important for stress and affective processing and further supports a possible etiological role of HCMV in depression.

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