Treatment and outcome data of very low birth weight infants treated with less invasive surfactant administration in comparison to intubation and mechanical ventilation in the clinical setting of a cross-sectional observational multicenter study

2018 ◽  
Vol 177 (8) ◽  
pp. 1207-1217 ◽  
Author(s):  
Kristina Langhammer ◽  
Bernhard Roth ◽  
Angela Kribs ◽  
Wolfgang Göpel ◽  
Ludwig Kuntz ◽  
...  
Author(s):  
S.H. Elbeely ◽  
M.A. AlQurashi

BACKGROUND: Very low birth weight infants born prematurely are at greater risk for growth delays that lead to Ex-utero Growth Restriction (EUGR) during vulnerable periods of organ structural and functional development. There is considerable evidence that early growth failure has adverse effects on long term neurodevelopment in children which often persists into adulthood. METHODS: This is a single-center cross-sectional study on live newborn infants with birth weight ranges from 500 to 1500 grams (VLBW) and gestational age (GA) between 24–32 weeks who were admitted to NICU at KAMC-Jeddah over a 5 year period (2009–2013). This study aims to evaluate predischarge growth pattern of VLBW infants in terms of weight, head circumference (HC) and length and to identify important variables that have influenced such growth pattern. RESULTS: Of the 135 infants included in the final analysis, 68 (50.4%) were male and 67 (49.6%) were female and the mean gestational age was 28.83±2.064 weeks and the mean birth weight 1166.74±256 grams. Ninety-two infants (68%) had discharge weight at ≤10th percentile and forty four (32%) had their weight >10th percentile. HC was the lowest affected among the anthropometric measurements with 42% ≤10th percentile. In terms of linear growth, 62% had their length ≤10th percentile. Amongst infants born ≤750 grams, 71% and 70% had HC and height at ≤10th percentile respectively, at the time of discharge. BPD was significantly associated with EUGR (p = 0.026). CONCLUSIONS: This study demonstrates that almost 2/3rd of VLBW infants born at KAMC-Jeddah with birth weight ≤750 grams were discharged home with EUGR as demonstrated by their weight, length, and HC ≤10th percentile. BPD was found to be significantly associated with EUGR amongst post-natal factors influencing EUGR.


2020 ◽  
Author(s):  
Marie Kouya ◽  
Annie Carole Nga Motaze ◽  
Jeannette Epee Ngoué ◽  
Arsene Brunelle Sandie ◽  
Paul Olivier Koki Ndombo ◽  
...  

Abstract Introduction. Vaccination is very often delayed in premature and low birth weight infants. However, timely vaccination is even more important in the latter because of their increased susceptibility to infection.Objective. To assess immunization practice and factors associated with vaccine promptness and completeness in former preterm and low-birth-weight infants.Methods. We conducted a retrospective analytical cross-sectional study (January 2017 to February 2019). Main measurement : Promptness and completeness at each contact, Statistical analysis was performed using R software version 3.6.2, logistic regression was used to estimate the Odds Ratio (OR) and their 95% Confidence Interval (CI).Results. We recruited 310 children aged 12 to 36 months born before 37 weeks with low birth weight, 163 (52.6%) of whom were female. Two hundred and fifty-three had received the vaccines at the indicated age, with promptness rate of 81.6%, and 97.7% had completed routine immunization at 9 months. The mean age at vaccination initiation was 6 days ±11 and the mean weight at vaccination initiation was 2233g ±494. High prematurity and very low birth weight were associated with a high rate of vaccine delay: 61.5% [OR: 15.56; (CI: 3.22-118.52; p=0.002)] and 66.7% [OR: 19.19; (CI: 4.67-92.52; p<0.001)] respectively. Distance > 5 km with HEC [OR: 3.48; (CI: 1.68-7.47; p=0.001)] was associated with poor vaccination. Women in common-law unions had the lowest vaccine readiness rate (60.6%), (OR: 3.36; CI: 1.006-10.70; p=0.038). The frequency of occurrence of post immunization adverse events was 24.5%, with fever type in 94.7%.Conclusion. Nearly all premature and/or low-birth-weight children hospitalized at Essos Hospital Center had completed routine immunization at 9 months, and the majority had received the vaccines in a timely manner. Similar study is needed in rural area.


PEDIATRICS ◽  
1982 ◽  
Vol 69 (5) ◽  
pp. 621-625
Author(s):  
Ronald S. Cohen ◽  
David K. Stevenson ◽  
Natalie Malachowski ◽  
Ronald L. Ariagno ◽  
Keith J. Kimble ◽  
...  

From 1961 to 1976, 229 infants with birth weights ranging from 751 to 1,000 gm were admitted to the Stanford University Hospital Intensive Care Nursery. The overall neonatal mortality for these infants was 63% (144/229), and there were ten late deaths. Before 1967, no infant in this group who required mechanical ventilation survived; therafter, 30% (34/114) of the ventilated patients survived. Of the 75 long-term survivors 60 participated in a high-risk infant follow-up program; these included 23 infants who had received mechanical ventilation. The mean birth weight of these infants was 928 ± 67 (SD) gm. Seventeen children (28%) had significant morbidity: seven (12%) with severe handicaps and ten (17%) with moderate handicaps. During this same period, seven infants weighing less than 750 gm at birth were also observed. The three infants who had not required ventilatory support thrived; the other four infants had required respirators and were significantly handicapped. More recently, neonatal mortality for infants with birth weights from 751 to 1,000 gm has improved: for 1977 to 1980, it was 28% (33/118). Furthermore, neonatal mortality for ventilated infants in this weight group was 27% (26/95). These data indicate an improved prognosis for very low-birth-weight infants, even with ventilatory support.


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