Review on medicinal plants and natural compounds as anti-Onchocerca agents

Background: Among non-communicable diseases, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in global communities. By 2030, CVD-related deaths are projected to reach a global rise of 25 million. Obesity, smoking, alcohol, hyperlipidemia, hypertension, and hyperhomocysteinemia are several known risk factors for CVDs. Elevated homocysteine is tightly related to CVDs through multiple mechanisms, including inflammation of the vascular endothelium. The strategies for appropriate management of CVDs are constantly evolving; medicinal plants have received remarkable attention in recent researches, since these natural products have promising effects on the prevention and treatment of various chronic diseases. The effects of nutraceuticals and herbal products on CVD/dyslipidemia have been previously studied. However, to our knowledge, the association between herbal bioactive compounds and homocysteine has not been reviewed in details. Thus, the main objective of this study is to review the efficacy of bioactive natural compounds on homocysteine levels according to clinical trials and animal studies. Results: Based on animal studies, black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced the homocysteine levels. According to the clinical trials, curcumin and resveratrol showed favorable effects on serum homocysteine. In conclusion, this review highlighted the beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies. Nevertheless, the results of the clinical trials were not uniform, suggesting that more well-designed trials are warranted.

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Virtual screening of natural compounds as combinatorial agents from indian medicinal plants against estrogen positive breast cancer

International Journal on Integrated Education ◽

10.31149/ijie.v3i10.750 ◽

2020 ◽

Vol 3 (10) ◽

pp. 266-275

Author(s):

Shaleen Jain ◽

Dr. Asmita Das

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Virtual Screening ◽

Medicinal Plants ◽

Natural Compounds ◽

Binding Energies ◽

Common Amino Acid ◽

Estrogen Receptor Positive ◽

Positive Breast Cancer

Facing worldwide challenges associated with multifactorial etiology of breast cancer, designing of combinatorial therapies using natural compounds is currently the emergent way of treating several cancers including breast cancer in a synergistic way, which may mitigate several problems associated with multiple receptor targeting. In this research, Estrogen receptor positive breast cancer was taken as prototype and several key receptors associated with this particular disease were targeted by virtual screening of natural compounds found in Indian originated medicinal plants using Computer aided Drug Designing (CADD) strategies. We found the combination of Carpusin, Paulownin Cornigerine, Nororientaline, Oryzalexin B, Romucosine H and Colchicine as effective against six potential receptors i.e. FGFR2, ESR1, PIK3CA, PIK3CB, PIK3CD and AR in Estrogen receptor positive breast cancer with their binding energies in the range of ∆G ≤ -8.0 Kcal/mol as well as significant number of common amino acid binding residues as compared with binding sites of receptors. Thus this research holds significant implications for the designing of combinatorial therapeutic agents against breast cancer which can be further tested in-vitro and in-vivo to prove their synergistic efficiency.

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Natural Compounds from Mexican Medicinal Plants as Potential Drug Leads for Anti-Tuberculosis Drugs

Anais da Academia Brasileira de Ciências ◽

10.1590/0001-3765201720160298 ◽

2017 ◽

Vol 89 (1) ◽

pp. 31-43 ◽

Cited By ~ 4

Author(s):

ROCIO GÓMEZ-CANSINO ◽

SILVIA LAURA GUZMÁN-GUTIÉRREZ ◽

MARÍA GUADALUPE CAMPOS-LARA ◽

CLARA INES ESPITIA-PINZÓN ◽

RICARDO REYES-CHILPA

Keyword(s):

Medicinal Plants ◽

Natural Compounds ◽

Potential Drug ◽

Drug Leads

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Medicinal Plants and Natural Compounds from the Genus Morus (Moraceae) with Hypoglycemic Activity: A Review

Glucose Tolerance ◽

10.5772/53145 ◽

2012 ◽

Cited By ~ 1

Author(s):

Jackson Roberto Guedes da Silva Almeida ◽

Grasielly Rocha ◽

Edigenia Cavalcante da Cruz Araujo ◽

Fabricio Souza ◽

Julianeli Tolentino de Lima ◽

...

Keyword(s):

Medicinal Plants ◽

Natural Compounds ◽

Hypoglycemic Activity

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Natural Compounds from Djiboutian Medicinal Plants as Inhibitors of COVID-19 by in Silico Investigations

10.26434/chemrxiv.12325844 ◽

2020 ◽

Author(s):

abdirahman elmi ◽

S. al jawad sayem ◽

Mohamed Ahmed ◽

fatouma mohamed

Keyword(s):

Medicinal Plants ◽

Natural Compounds ◽

Binding Energies ◽

Receptor Binding Domain ◽

Global Pandemic ◽

Main Protease ◽

Target Sites ◽

Better Than

The new coronavirus type SARS-Cov 2 (severe acute respiratory syndrome), which appeared in autumn 2019 in China, became a global pandemic in a few months. In this work, we looked for the potential anti SARS-Cov 2 of the compounds isolated from three Djiboutian medicinal plants namely Acacia seyal, Cymbopogon commutatus, and Indigofera caerulea. For this we carried out a docking with nine biomolecules, β-Sitosterol , Quercetin, Catechin, Lupeol, Rutin, Kaempferol, Gallic acid, Piperitone and Limonene on three target sites which are SARS-CoV-2 main protease (Mp), SARS-CoV-2 receptor binding domain (RBD) and human furin protease. These targets are chosen because of their role in the process of penetration of the virus into human cells and its multiplication. The phenolic compounds have a very good afinity on these three target sites with binding energies of up to -9.098 kcal/mol for rutin on SARS-CoV-2 Mp, much better than the two reference drugs hydroxychloroquine (-5.816 kcal / mol) and remdesivir (-7.194 kcal/mol). These natural compounds do not present toxicities and can be used pending In vitro and In vivo evaluations.

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Medicinal plants and bioactive natural compounds as inhibitors of HMG‐CoA reductase: A literature review

BioFactors ◽

10.1002/biof.1684 ◽

2020 ◽

Vol 46 (6) ◽

pp. 906-926 ◽

Cited By ~ 1

Author(s):

Atena Mahdavi ◽

Mohammad Bagherniya ◽

Omid Fakheran ◽

Željko Reiner ◽

Suowen Xu ◽

...

Keyword(s):

Medicinal Plants ◽

Literature Review ◽

Natural Compounds ◽

Hmg Coa Reductase ◽

Coa Reductase

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NATURAL COMPOUNDS FROM DJIBOUTIAN MEDICINAL PLANTS AS INHIBITORS OF COVID-19 BY IN SILICO INVESTIGATIONS

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i4.39051 ◽

2020 ◽

pp. 52-57

Author(s):

ABDIRAHMAN ELMI ◽

S. AL-JAWAD SAYEM ◽

MOHAMED AHMED ◽

FATOUMA ABDOUL-LATIF

Keyword(s):

Medicinal Plants ◽

Natural Compounds ◽

Binding Energies ◽

Pharmacokinetic Parameters ◽

Global Pandemic ◽

Main Protease ◽

Target Sites ◽

Better Than

Objective: The new coronavirus type SARS-Cov 2 (severe acute respiratory syndrome), which appeared in autumn 2019 in China, became a global pandemic in a few months. In this work, we looked for the potential anti SARS-Cov 2 of the compounds isolated from three Djiboutian medicinal plants, namely Acacia seyal, Cymbopogon commutatus, and Indigofera caerulea. Methods: We carried out a molecular docking with nine biomolecules, β-Sitosterol, Quercetin, Catechin, Lupeol, Rutin, Kaempferol, Gallic acid, Piperitone and Limonene on three target sites which are SARS-CoV-2 main protease (Mp), SARS-CoV-2 receptor-binding domain (RBD) and human furin protease. These targets are chosen because of their role in the process of penetration of the virus into human cells and its multiplication. Moreover, the predictions of pharmacokinetic parameters as well as toxicological properties have been determined using an online bioinformatics tool named SwissADME and AdmetSAR respectively. Results: The phenolic compounds have a very good affinity on these three target sites with binding energies of up to-9.098 kcal/mol for rutin on SARS-CoV-2 Mp, much better than the two reference drugs hydroxychloroquine (-5.816 kcal/mol) and remdesivir (-7.194 kcal/mol). Except for β-Sitosterol, the tested biomolecules have weak toxicity. Conclusion: These natural compounds can be used against covid 19 pending In vitro and In vivo evaluations.

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Discovery of leishmanicidal agents from medicinal plants

Pure and Applied Chemistry ◽

10.1351/pac200880081783 ◽

2008 ◽

Vol 80 (8) ◽

pp. 1783-1790 ◽

Cited By ~ 9

Author(s):

◽

M. Iqbal Choudhary ◽

◽

Keyword(s):

Medicinal Plants ◽

Cutaneous Leishmaniasis ◽

Natural Compounds ◽

Antileishmanial Activity

Antileishmanial activity of several classes of natural compounds was evaluated by using an in vitro parasitic assay model. This has led to the discovery of new antileishmanial agents with potential to be useful in the treatment of visceral and cutaneous leishmaniasis.

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Parkinson’s disease: A current perspectives on Parkinson’s disease and key bioactive natural compounds as future potential drug candidates

Current Drug Targets ◽

10.2174/1389450122666210623115505 ◽

2021 ◽

Vol 22 ◽

Author(s):

Nabeel Ali ◽

Amna Syeda ◽

Tenzin Topgyal ◽

Naseem Gaur ◽

Asimul Islam

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Side Effects ◽

Medicinal Plants ◽

The Elderly ◽

Natural Compounds ◽

Muscle Stiffness ◽

Drug Candidates ◽

Gradual Loss ◽

Life Threatening

: Parkinson’s disease (PD) is one of the most common types of neurological disorder prevailing worldwide and is rapidly increasing in the elderly population across the globe. The cause of PD is still unknown, but a number of genetic as well as environmental factors contributing to the pathogenesis of Parkinson’s disease have been identified. The hallmark of PD includes dopamine deficiency (neurotransmitter imbalance) due to the gradual loss of dopaminergic nerves in the substantia nigra in the midbrain. Studying the mutation of associated genes is particularly informative in understanding the fundamental molecular and pathogenic changes in PD. Intracellular accumulation of misfolded or degraded protein due to mutated gene leads to the manifestation of mitochondrial dysfunction, oxidative stress followed by multifaceted patho-physiologic symptoms. Other studies include the appearance of motor and non-motor responses like resting tremor, muscle stiffness, slow movement and anxiety, anaemia, constipation, rapid eye movement and sleep behaviour disorder. Many bioactive natural compounds have shown positive pharmacological results in treating a number of extensive disease models of PD. Despite the availability of an end number of potent medicinal plants around the world, limited research has been done associated with various neurological disorders, including PD. The currently available dopamine-based drug treatments have several side effects; further, they are not effective enough to combat PD completely. Therefore, various plant-based compounds with medicinal benefits have grabbed lots of attention from researchers to deal with various life-threatening neurodegenerative disorders like PD. On the basis of literature available to date, here, we have discussed and addressed the molecular basis, current scenario, and the best possible treatment of PD for the future with minimal or no side-effects using various key bioactive compounds from natural origin/medicinal plants.

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