Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking

2018 ◽  
Vol 32 (11) ◽  
pp. 4673-4680 ◽  
Author(s):  
Chih-Tsung Wen ◽  
Yu-Yin Liu ◽  
Hsin-Yueh Fang ◽  
Ming-Ju Hsieh ◽  
Yin-Kai Chao
Keyword(s):  
Near Infrared ◽  
Lung Tumor ◽  
Tumor Resection ◽  
Image Guided ◽  
Video Assisted

scholarly journals Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

2017 ◽  
Vol 8 (4) ◽  
pp. 2782-2789 ◽  
Author(s):  
Jie Liu ◽  
Chao Chen ◽  
Shenglu Ji ◽  
Qian Liu ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Fluorescent Nanoparticles ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Long Wavelength ◽  
Image Guided ◽  
Fluorescent Molecules

Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

2019 ◽  
Vol 62 (11) ◽  
pp. 1472-1480 ◽  
Author(s):  
Xiaoyan Zhang ◽  
Cong Li ◽  
Wenyi Liu ◽  
Hanlin Ou ◽  
Dan Ding
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Aggregation Induced Emission ◽  
Image Guided

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer

2010 ◽  
Vol 128 (3) ◽  
pp. 679-689 ◽  
Author(s):  
J. Sven D. Mieog ◽  
Merlijn Hutteman ◽  
Joost R. van der Vorst ◽  
Peter J. K. Kuppen ◽  
Ivo Que ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Real Time ◽  
Rat Model ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Tumor Resection ◽  
Near Infrared Fluorescence ◽  
Image Guided

scholarly journals Ex Vivo Assessment of Tumor-Targeting Fluorescent Tracers for Image-Guided Surgery

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 987
Author(s):  
Fortuné M.K. Elekonawo ◽  
Jan Marie de Gooyer ◽  
Desirée L. Bos ◽  
David M. Goldenberg ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Near Infrared ◽  
Ex Vivo ◽  
Tumor Resection ◽  
Human Tumor ◽  
Image Guided Surgery ◽  
Radioactive Label ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Image Guided

Image-guided surgery can aid in achieving complete tumor resection. The development and assessment of tumor-targeted imaging probes for near-infrared fluorescence image-guided surgery relies mainly on preclinical models, but the translation to clinical use remains challenging. In the current study, we introduce and evaluate the application of a dual-labelled tumor-targeting antibody for ex vivo incubation of freshly resected human tumor specimens and assessed the tumor-to-adjacent tissue ratio of the detectable signals. Immediately after surgical resection, peritoneal tumors of colorectal origin were placed in cold medium. Subsequently, tumors were incubated with 111In-DOTA-hMN-14-IRDye800CW, an anti-carcinoembryonic antigen (CEA) antibody with a fluorescent and radioactive label. Tumors were then washed, fixed, and analyzed for the presence and location of tumor cells, CEA expression, fluorescence, and radioactivity. Twenty-six of 29 tumor samples obtained from 10 patients contained malignant cells. Overall, fluorescence intensity was higher in tumor areas compared to adjacent non-tumor tissue parts (p < 0.001). The average fluorescence tumor-to-background ratio was 11.8 ± 9.1:1. A similar ratio was found in the autoradiographic analyses. Incubation with a non-specific control antibody confirmed that tumor targeting of our tracer was CEA-specific. Our results demonstrate the feasibility of this tracer for multimodal image-guided surgery. Furthermore, this ex vivo incubation method may help to bridge the gap between preclinical research and clinical application of new agents for radioactive, near infrared fluorescence or multimodal imaging studies.

scholarly journals Molecular persistent luminescence imaging with porphyrin derivatives for ultrasensitive image-guided cancer surgery and drug screening

2021 ◽  
Author(s):  
Xingchen Duan ◽  
Guoqiang Zhang ◽  
Shenglu Ji ◽  
Yiming Zhang ◽  
Jun Li ◽  
...  
Keyword(s):  
Drug Screening ◽  
Near Infrared ◽  
Tumor Resection ◽  
Cancer Surgery ◽  
Great Promise ◽  
Persistent Luminescence ◽  
Excitation Light ◽  
Image Guided ◽  
Porphyrin Derivatives ◽  
Tumor Identification

Persistent luminescence without excitation light and tissue autofluorescence interference holds great promise for in vivo imaging and sensing. However, the availability of persistence luminescence materials is largely limited by potential toxicity, instability, short-wavelength emissions, and poor clinical potential for currently available ones. Here we report a series of porphyrin derivatives with near-infrared (NIR) persistence luminescence for image-guided cancer surgery and drug screening. These porphyrin derivatives showed NIR persistence luminescence over 760 nm after cessation of excitation light or upon interaction with peroxynitrite (ONOO-), and a plausible mechanism of ordered oxidation of vinylene bond is proposed. Through molecular engineering with adaptive peptides bearing the functions of β-sheet-formatting and cancer cell targeting, the resultant Ppa-FFGYSA supermolecular probe showed enhanced photoacoustic and persistence luminescence signals, facilitating preoperative photoacoustic tumor identification and intraoperative persistence luminescence image-guided tumor resection with outperformed signal-to-background ratio. In addition, the activated persistence luminescence in recognition of ONOO- also permits the specific monitoring of neutrophil infiltration and screening of immunogenic cell death (ICD) drugs with high sensitivity and specificity.

Lung Tumor Resection Ups Melanoma Survival

2007 ◽  
Vol 38 (7) ◽  
pp. 46
Author(s):  
ALICIA AULT
Keyword(s):  
Lung Tumor ◽  
Tumor Resection

scholarly journals Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
Jie Tian ◽  
Zhenhua Hu
Keyword(s):  
Fluorescent Probes ◽  
Signal Intensity ◽  
Tumor Imaging ◽  
Tumor Resection ◽  
Optical Signal ◽  
Gadolinium Oxide ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

scholarly journals F-150PROSPECTIVE STUDY OF NEAR-INFRARED THORACOSCOPY FOR INTERSEGMENTAL PLANE IDENTIFICATION DURING VIDEO-ASSISTED THORACOSCOPIC SEGMENTECTOMY

2016 ◽  
Vol 23 (suppl 1) ◽  
pp. i41.2-i41
Author(s):  
Sebastien Guigard ◽  
W. Karenovics ◽  
M. Licker ◽  
J. Vidal-Fortuny ◽  
F. Triponez
Keyword(s):  
Near Infrared ◽  
Video Assisted ◽  
Intersegmental Plane

scholarly journals Evaluation of Intraoperative Near-Infrared Fluorescence Visualization of the Lung Tumor Margin With Indocyanine Green Inhalation

JAMA Surgery ◽  
2020 ◽  
Vol 155 (8) ◽  
pp. 732 ◽  
Author(s):  
Yu Hua Quan ◽  
Chan Hee Oh ◽  
Daeho Jung ◽  
Ji-Young Lim ◽  
Byeong Hyeon Choi ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Lung Tumor ◽  
Near Infrared Fluorescence ◽  
Tumor Margin
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