Surface-adaptive nanoparticles with near-infrared aggregation-induced emission for image-guided tumor resection

2019 ◽  
Vol 62 (11) ◽  
pp. 1472-1480 ◽  
Author(s):  
Xiaoyan Zhang ◽  
Cong Li ◽  
Wenyi Liu ◽  
Hanlin Ou ◽  
Dan Ding
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Aggregation Induced Emission ◽  
Image Guided

scholarly journals Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

2017 ◽  
Vol 8 (4) ◽  
pp. 2782-2789 ◽  
Author(s):  
Jie Liu ◽  
Chao Chen ◽  
Shenglu Ji ◽  
Qian Liu ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Fluorescent Nanoparticles ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Long Wavelength ◽  
Image Guided ◽  
Fluorescent Molecules

Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. 1110-1114 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Shidang Xu ◽  
Shenglu Ji ◽  
Fang Hu ◽  
...  
Keyword(s):  
High Performance ◽  
Near Infrared ◽  
Anticancer Therapy ◽  
Infrared Emission ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Near Infrared Emission

A series of D–A′–π–A type photosensitizers were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously, and have been successfully used for image-guided photodynamic anticancer therapy.

A Highly Efficient and Photostable Photosensitizer with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Anticancer Therapy

2017 ◽  
Vol 29 (33) ◽  
pp. 1700548 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Fang Hu ◽  
Shidang Xu ◽  
Chao Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Anticancer Therapy ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Highly Efficient

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer

2010 ◽  
Vol 128 (3) ◽  
pp. 679-689 ◽  
Author(s):  
J. Sven D. Mieog ◽  
Merlijn Hutteman ◽  
Joost R. van der Vorst ◽  
Peter J. K. Kuppen ◽  
Ivo Que ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Real Time ◽  
Rat Model ◽  
Primary Breast Cancer ◽  
Near Infrared ◽  
Tumor Resection ◽  
Near Infrared Fluorescence ◽  
Image Guided

Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery

Nano Letters ◽  
2018 ◽  
Vol 19 (1) ◽  
pp. 318-330 ◽  
Author(s):  
Xiang Ni ◽  
Xiaoyan Zhang ◽  
Xingchen Duan ◽  
Han-Liang Zheng ◽  
Xiao-Song Xue ◽  
...  
Keyword(s):  
Near Infrared ◽  
Cancer Surgery ◽  
Signal Ratio ◽  
Aggregation Induced Emission ◽  
Image Guided

scholarly journals Ex Vivo Assessment of Tumor-Targeting Fluorescent Tracers for Image-Guided Surgery

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 987
Author(s):  
Fortuné M.K. Elekonawo ◽  
Jan Marie de Gooyer ◽  
Desirée L. Bos ◽  
David M. Goldenberg ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Near Infrared ◽  
Ex Vivo ◽  
Tumor Resection ◽  
Human Tumor ◽  
Image Guided Surgery ◽  
Radioactive Label ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Image Guided

Image-guided surgery can aid in achieving complete tumor resection. The development and assessment of tumor-targeted imaging probes for near-infrared fluorescence image-guided surgery relies mainly on preclinical models, but the translation to clinical use remains challenging. In the current study, we introduce and evaluate the application of a dual-labelled tumor-targeting antibody for ex vivo incubation of freshly resected human tumor specimens and assessed the tumor-to-adjacent tissue ratio of the detectable signals. Immediately after surgical resection, peritoneal tumors of colorectal origin were placed in cold medium. Subsequently, tumors were incubated with 111In-DOTA-hMN-14-IRDye800CW, an anti-carcinoembryonic antigen (CEA) antibody with a fluorescent and radioactive label. Tumors were then washed, fixed, and analyzed for the presence and location of tumor cells, CEA expression, fluorescence, and radioactivity. Twenty-six of 29 tumor samples obtained from 10 patients contained malignant cells. Overall, fluorescence intensity was higher in tumor areas compared to adjacent non-tumor tissue parts (p < 0.001). The average fluorescence tumor-to-background ratio was 11.8 ± 9.1:1. A similar ratio was found in the autoradiographic analyses. Incubation with a non-specific control antibody confirmed that tumor targeting of our tracer was CEA-specific. Our results demonstrate the feasibility of this tracer for multimodal image-guided surgery. Furthermore, this ex vivo incubation method may help to bridge the gap between preclinical research and clinical application of new agents for radioactive, near infrared fluorescence or multimodal imaging studies.

scholarly journals Molecular persistent luminescence imaging with porphyrin derivatives for ultrasensitive image-guided cancer surgery and drug screening

2021 ◽  
Author(s):  
Xingchen Duan ◽  
Guoqiang Zhang ◽  
Shenglu Ji ◽  
Yiming Zhang ◽  
Jun Li ◽  
...  
Keyword(s):  
Drug Screening ◽  
Near Infrared ◽  
Tumor Resection ◽  
Cancer Surgery ◽  
Great Promise ◽  
Persistent Luminescence ◽  
Excitation Light ◽  
Image Guided ◽  
Porphyrin Derivatives ◽  
Tumor Identification

Persistent luminescence without excitation light and tissue autofluorescence interference holds great promise for in vivo imaging and sensing. However, the availability of persistence luminescence materials is largely limited by potential toxicity, instability, short-wavelength emissions, and poor clinical potential for currently available ones. Here we report a series of porphyrin derivatives with near-infrared (NIR) persistence luminescence for image-guided cancer surgery and drug screening. These porphyrin derivatives showed NIR persistence luminescence over 760 nm after cessation of excitation light or upon interaction with peroxynitrite (ONOO-), and a plausible mechanism of ordered oxidation of vinylene bond is proposed. Through molecular engineering with adaptive peptides bearing the functions of β-sheet-formatting and cancer cell targeting, the resultant Ppa-FFGYSA supermolecular probe showed enhanced photoacoustic and persistence luminescence signals, facilitating preoperative photoacoustic tumor identification and intraoperative persistence luminescence image-guided tumor resection with outperformed signal-to-background ratio. In addition, the activated persistence luminescence in recognition of ONOO- also permits the specific monitoring of neutrophil infiltration and screening of immunogenic cell death (ICD) drugs with high sensitivity and specificity.

Image-guided video-assisted thoracoscopic small lung tumor resection using near-infrared marking

2018 ◽  
Vol 32 (11) ◽  
pp. 4673-4680 ◽  
Author(s):  
Chih-Tsung Wen ◽  
Yu-Yin Liu ◽  
Hsin-Yueh Fang ◽  
Ming-Ju Hsieh ◽  
Yin-Kai Chao
Keyword(s):  
Near Infrared ◽  
Lung Tumor ◽  
Tumor Resection ◽  
Image Guided ◽  
Video Assisted
Sign in / Sign up

Export Citation Format

Share Document