Patient-reported symptom burden and supportive care needs at cancer diagnosis: a retrospective cohort study

Abstract Background: The health burden of breast cancer is rising in China. The effect of informed diagnosis on long-term survival has not been fully understood. This retrospective cohort study aims at exploring the association between early informed diagnosis and survival time in breast cancer patients.Methods: 12,327 breast cancer patients were enrolled between October 2002 and December 2016. Potential factors including knowing cancer diagnosis status, gender, age, clinical-stage, surgical history, the grade of reporting hospital and diagnostic year were registered. We followed up all participants every 6 months until June 2017.Results: By June 2017, 18.04% of the participants died of breast cancer. Both the 3-year and 5-year survival rate of whom knew cancer diagnosis were longer (P<0.001). By stratified analysis, except subgroups of male patients and patients in stage III, patients knowing diagnosis showed a better prognosis in all the other subgroups (P<0.05). By Cox regression analysis, it was showed that not knowing cancer diagnosis was an independent risk factor for survival in breast cancer patients (P<0.001).Conclusions: Being aware of their cancer diagnosis plays a protective role in extending the survival time in breast cancer patients, which suggests medical staff and patients’ families disclose cancer diagnosis to patients timely.

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Unmet supportive care needs in Hispanic/Latino cancer survivors: prevalence and associations with patient-provider communication, satisfaction with cancer care, and symptom burden

Supportive Care in Cancer ◽

10.1007/s00520-018-4426-4 ◽

2018 ◽

Vol 27 (4) ◽

pp. 1383-1394 ◽

Cited By ~ 10

Author(s):

Patricia I. Moreno ◽

Amelie G. Ramirez ◽

Sandra L. San Miguel-Majors ◽

Leopoldo Castillo ◽

Rina S. Fox ◽

...

Keyword(s):

Supportive Care ◽

Cancer Survivors ◽

Cancer Care ◽

Symptom Burden ◽

Communication Satisfaction ◽

Supportive Care Needs ◽

Provider Communication ◽

Care Needs ◽

Patient Provider Communication

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Contralateral prophylactic mastectomy at the time of delayed microvascular breast reconstruction adversely affects patient-reported outcomes: A retrospective cohort study

Journal of Plastic Reconstructive & Aesthetic Surgery ◽

10.1016/j.bjps.2020.10.020 ◽

2020 ◽

Author(s):

Isabel Kerrebijn ◽

Helene Retrouvey ◽

Maiju Härmä ◽

Stephanie Sebastiampillai ◽

Toni Zhong ◽

...

Keyword(s):

Cohort Study ◽

Breast Reconstruction ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Patient Reported Outcomes ◽

Prophylactic Mastectomy ◽

Contralateral Prophylactic Mastectomy ◽

Patient Reported

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Retrospective cohort study of the relationship between systolic blood pressure variability and multiple sclerosis disability

BMJ Open ◽

10.1136/bmjopen-2019-034355 ◽

2020 ◽

Vol 10 (2) ◽

pp. e034355 ◽

Cited By ~ 1

Author(s):

Myla D Goldman ◽

Seulgi Min ◽

Jennifer M Lobo ◽

Min-Woong Sohn

Keyword(s):

Multiple Sclerosis ◽

Blood Pressure ◽

Cohort Study ◽

Systolic Blood Pressure ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Outcome Measure ◽

Patient Reported Outcome ◽

Patient Reported ◽

The Relationship

ObjectiveTo examine the relationship between visit-to-visit systolic blood pressure (SBP) variability and patient-reported outcome measure of disability in multiple sclerosis (MS) patients.DesignA retrospective cohort study of individuals with MS who completed a patient-determined disease steps (PDDS) scale between 2011 and 2015 at an MS specialty clinic.ParticipantsIndividuals with MS for whom both a completed PDDS scale and ≥3 SBP measures within the prior 12 months of the survey were available.Main outcome measureParticipants were grouped into three classes of disability (no or mild (PDDS 0–1), moderate (2–3), severe (4–7)). SBP variability was calculated as within-subject SD using all SBP measures taken during the past 12 months. SBP variability was analysed by Tertile groups.ResultsNinety-two subjects were included in this analysis. Mean PDDS score was 2.22±1.89. Compared with subjects in Tertile 1 (lowest variability), the odds of being in a higher disability group was 3.5 times higher (OR=3.48; 95% CI: 1.08 to 11.25; p=0.037) in Tertile 2 and 5.2 times higher (OR=5.19; 95% CI: 1.53 to 17.61; p=0.008) in Tertile 3 (highest variability), independent of mean SBP, age, sex, race/ethnicity, body mass index and comorbidities (p for trend=0.008). Mean PDDS scores were 1.52±1.18 in Tertile 1, 2.73±1.02 in Tertile 2 and 2.42±0.89 in Tertile 3 after adjusting for the same covariates.ConclusionsOur results show a significant gradient relationship between SBP variability and MS-related disability. More research is needed to determine the underlying pathophysiological relationship between SBP variability and MS disability progression.

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Understanding the supportive care needs of early-phase cancer clinical trial (CT) participants.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.29_suppl.26 ◽

2020 ◽

Vol 38 (29_suppl) ◽

pp. 26-26

Author(s):

Debra Lundquist ◽

Dejan Juric ◽

Rachel Jimenez ◽

Virginia Capasso ◽

Casandra McIntyre ◽

...

Keyword(s):

Supportive Care ◽

Early Phase ◽

Poor Prognosis ◽

Phase 1 ◽

Supportive Care Needs ◽

Care Needs ◽

Targeted Interventions ◽

Care Services ◽

Patient Reported ◽

Prognosis Score

26 Background: Early phase CTs investigate novel therapeutic approaches for patients with cancer, but little is known about the use of supportive care services among participants in early phase CTs. Methods: We conducted a retrospective chart review of consecutive patients enrolled in Phase 1 CTs from 2017-2019, capturing sociodemographics, clinical data, and use of supportive care services from the electronic health record. We calculated the Royal Marsden Hospital (RMH) prognostic score using data at the time of CT trial enrollment based on patients’ lactate dehydrogenase, albumin, and number of sites of metastasis. The RMH score ranges from 0-3, with scores of 2+ indicating a poor prognosis. We explored differences in patient characteristics, supportive care use, and clinical outcomes based on the RMH prognosis score. Results: Among 426 patients treated on Phase 1 CTs during the study period, the median age was 63.0 years (range 20.5-85.2 years), and most were female (56.1%), white race (85.1%), and had metastatic cancer (97.7%). The most common cancer types were gastrointestinal (22.1%), lung (20.0%), and breast (10.6%) cancer. Under half (31.6%) had an RMH score indicating a poor prognosis. Patients with a poor prognosis score had a worse performance status (ECOG ≥1: 80.2% v 58.3%, p < .001) and more prior treatment (3+ prior lines: 49.5% v 35.0%, p = .001) compared to those without a poor prognosis score. Those with a poor prognosis score were more likely to receive palliative care before or during CT participation (40.5% v 27.1%, p = .011). We observed no significant differences in the rates of nutrition (69.1% v 64.0%), social work (62.2% v 63.8%), or physical therapy (64.5% v 61.7%) consults between those with and without a poor prognosis score. We found that those with an RMH score indicating a poor prognosis had a shorter time on trial (median: 49 vs 87 days, p < .001) and worse survival (median: 139 v 379 days, p < .001). Conclusions: Early phase CT participants represent an advanced cancer population with unique supportive care needs, and we identified a group with a particularly poor prognosis for whom earlier intervention with supportive care services may be needed. Our findings highlight the need to prospectively examine these characteristics along with patient-reported outcomes to better understand the distinct supportive care needs of this population and guide the development of targeted interventions.

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