Microinflammation in the intestinal mucosa and symptoms of irritable bowel syndrome

2021 ◽  
Author(s):  
Takanori Yoshimoto ◽  
Tadayuki Oshima ◽  
Xinyi Huang ◽  
Toshihiko Tomita ◽  
Hirokazu Fukui ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Mucosa ◽  
Irritable Bowel

Mast cells are increased in the small intestinal mucosa of patients with irritable bowel syndrome: A systematic review and meta‐analysis

2019 ◽  
Vol 31 (12) ◽  
Author(s):  
Alejandro Robles ◽  
David Perez Ingles ◽  
Kanchana Myneedu ◽  
Abhizith Deoker ◽  
Irene Sarosiek ◽  
...  
Keyword(s):  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Intestinal Mucosa ◽  
Meta Analysis ◽  
Small Intestinal Mucosa ◽  
Small Intestinal ◽  
Irritable Bowel

scholarly journals Colonic Mucosal Immune Activation in Mice with Ovalbumin-Induced Allergic Airway Disease: Association between Allergic Airway Disease and Irritable Bowel Syndrome

2021 ◽  
Vol 23 (1) ◽  
pp. 181
Author(s):  
Sanghyun Kim ◽  
Bora Keum ◽  
Junhyoung Byun ◽  
Byoungjae Kim ◽  
Kijeong Lee ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Inflammatory Response ◽  
Intestinal Mucosa ◽  
Inflammatory Responses ◽  
Airway Disease ◽  
Allergic Airway Disease ◽  
Airway Diseases ◽  
Cytokine Levels ◽  
Irritable Bowel

Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.

Confocal Endomicroscopy Shows Food-Associated Changes in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

2014 ◽  
Vol 147 (5) ◽  
pp. 1012-1020.e4 ◽  
Author(s):  
Annette Fritscher-Ravens ◽  
Detlef Schuppan ◽  
Mark Ellrichmann ◽  
Stefan Schoch ◽  
Christoph Röcken ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Mucosa ◽  
Confocal Endomicroscopy ◽  
Irritable Bowel

scholarly journals The Effect of Tong-Xie-Yao-Fang on Intestinal Mucosal Mast Cells in Postinfectious Irritable Bowel Syndrome Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiangxue Ma ◽  
Xiaoge Wang ◽  
Nan Kang ◽  
Ting Chen ◽  
Haijie Ji ◽  
...  
Keyword(s):  
Mast Cell ◽  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Intestinal Mucosa ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Mucosal Mast Cells ◽  
Fos Expression ◽  
Irritable Bowel ◽  
Postinfectious Irritable Bowel Syndrome

Objective. To investigate the effects of Tong-Xie-Yao-Fang (TXYF) on intestinal mucosal mast cells in rats with postinfectious irritable bowel syndrome (PI-IBS).Design. PI-IBS rat models were established using a multistimulation paradigm. Then, rats were treated with TXYF intragastrically at doses of 2.5, 5.0, and 10.0 g·kg−1·d−1for 14 days, respectively. Intestinal sensitivity was assessed based on abdominal withdrawal reflex (AWR) scores and fecal water content (FWC). Mast cell counts and the immunofluorescence of tryptase and c-Fos in intestinal mucosa were measured; and serum IL-1β, TNF-α, and histamine levels were determined.Results. AWR reactivity and FWC which were significantly increased could be observed in PI-IBS rats. Remarkably increased mast cell activation ratio in intestinal mucosa, together with increased serum TNF-αand histamine levels, could also be seen in PI-IBS rats; furthermore, PI-IBS-induced changes in mast cell activation and level of serum TNF-αand histamine could be reversed by TXYF treatment. Meanwhile, tryptase and c-Fos expression were also downregulated.Conclusion. TXYF improves PI-IBS symptoms by alleviating behavioral hyperalgesia and antidiarrhea, the underlying mechanism of which involves the inhibitory effects of TXYF on activating mucosal mast cells, downregulating tryptase and c-Fos expression, and reducing serum TNF-αand histamine levels.

scholarly journals Morphological manifestations of irritable bowel syndrome

2021 ◽  
Vol 55 (2) ◽  
pp. 108-114
Author(s):  
Yu.M. Stepanov ◽  
I.Ya. Budzak ◽  
Yu.A. Gaidar
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Tight Junctions ◽  
Intestinal Mucosa ◽  
Morphological Changes ◽  
Low Grade ◽  
Intercellular Contacts ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The article presents modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome. There were analyzed the studies of different years on the morphological manifestations of irritable bowel syndrome. It has been shown that this pathology has an unusual low-grade inflammation. Mast cells play an important role in these inflammatory disorders, they have an effect on motility disorders, visceral hypersensitivity and other pathogenetic factors of irritable bowel syndrome. Disorders of intercellular tight junctions in this category of patients were also analyzed. The role of proteins involved in intercellular contacts (occludin, claudin, ZO) has been characterized. An analysis of the studies investigating these disorders has been carried out. The article provides examples of the analysis of biopsies in patients with irritable bowel syndrome using various methods of their assessment.

Expression of intestinal mucosa tight junctions claudin proteins and mRNA in patients with irritable bowel syndrome

2007 ◽  
Vol 22 (3) ◽  
pp. 153-159
Author(s):  
Wu-ming KONG ◽  
Jun GONG ◽  
Lei DONG ◽  
Xiao-lan LU ◽  
Junrong XU
Keyword(s):  
Irritable Bowel Syndrome ◽  
Tight Junctions ◽  
Intestinal Mucosa ◽  
Irritable Bowel
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