The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus

2014 ◽  
Vol 51 (5) ◽  
pp. 731-738 ◽  
Author(s):  
Kristiina Tertti ◽  
Kari Laine ◽  
Ulla Ekblad ◽  
Valtteri Rinne ◽  
Tapani Rönnemaa
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fetal Outcome

scholarly journals A study of gestational diabetes mellitus and fetal outcome in a tertiary care center

2020 ◽  
Vol 9 (8) ◽  
pp. 3417
Author(s):  
Aashka M. Mashkaria ◽  
Babulal S. Patel ◽  
Aastha M. Mashkaria ◽  
Akshay C. Shah ◽  
Shashwat K. Jani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Early Diagnosis ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Care Center ◽  
Tertiary Care ◽  
Tolerance Test ◽  
Fetal Outcome ◽  
Oral Glucose ◽  
Glucose Levels

Background: Modern desk-bound lifestyle and unhealthy dietary changes have brought a rise in the prevalence of obesity and gestational diabetes mellitus (GDM). It is associated with severe hazards to the mother and the baby. It is mandatory that early diagnosis ensues and timely and congruous management is undertaken.Methods: In this observational study, 1250 women were included. A standardized questionnaire was formed and their details were noted. Tests for glucose levels, complete blood picture, urine examination were performed. An oral glucose tolerance test was performed on all the patients. Neonatal outcomes in terms of birth weight and the presence of complications were noted.Results: A total 201 (16.1%) of all women were having gestational diabetes mellitus (GDM). Most mothers were in the 25-30 age group. The majority of the women had a BMI between 26-30. 21.9% of babies were having weight >3.5 kgs. 11.4% of babies were <2.5 kgs. Out of 201 neonates, 90 babies were having complications. Major complications in neonates were macrosomia and respiratory distress. Therefore, early diagnosis, glycemic control, and timely and congruous management are advantageous to both mother and baby.Conclusions: GDM complicating the pregnancy results in a higher prevalence of complications in the mother and the neonate. Therefore, appropriate control of the sugar level in mothers is necessary and it decreases the morbidity and mortality rates in the babies as well as the mothers. 

scholarly journals Polycystic ovarian syndrome and pregnancy outcome

2017 ◽  
Vol 6 (9) ◽  
pp. 3804
Author(s):  
Chaitra Shivananjaiah ◽  
Abinaya Kannan ◽  
Mridula Devi ◽  
. Jayanthi ◽  
Satish D. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Gestational Age ◽  
Polycystic Ovarian Syndrome ◽  
Mode Of Delivery ◽  
Fetal Outcome ◽  
Hypertensive Disorder ◽  
Ovarian Syndrome ◽  
In Pregnancy

Background: Polycystic ovarian syndrome (PCOS) in the present generation is a very common reproductive disorder and the prevalence is on the rise. It is associated with typical features such as insulin resistance, hyperandrogenemia and obesity which has deep implications on the pregnancy outcomes as well as a long-term health of the woman.Methods: Prospective comparative study performed over 200 pregnant women in the ESIC medical college, Bangalore. 100 women diagnosed with PCOS were compared with that of 100 normal women. The method of conception in pcos was recorded. maternal outcome in the form of abortion, gestational diabetes mellitus, hypertensive disorder in pregnancy, mode of delivery, intrapartum and postpartum complication. Fetal outcome in the form preterm delivery, small-for-gestational-age (SGA) infants, large-for-gestational-age infants, apgar at 5 minute and admission to NICU.Results: Of the 100 women who were diagnosed with PCOS, 62 had spontaneous conception, 32 conceived with ovulation induction, 4 with artificial insemination and 2 needed IVF for conception. 18 women had spontaneous abortion, 58 were diagnosed with Gestational diabetes mellitus (GDM) predominantly between 24 – 28 weeks’ period of gestation, 16 women had hypertension complicating pregnancy. Fetal outcome in the form of preterm birth was noted in 14 patients, large for gestation was noted in 11 newborns, the rate of NICU admission was significantly higher in the PCOS women’s infants constituting 33%.Conclusions: The assistance needed for conception was significantly higher in women with PCOS. The complications associated with pregnancy such as spontaneous abortions, gestational diabetes, hypertensive disorder in pregnancy, preterm births, need of NICU care for the infants are much higher in women with PCOS.  Adult health education and the preconception diagnosis and appropriate management of PCOS is an important primary mode of prevention of these associated complications. 

scholarly journals Survey of obstetric and neonatal outcome in gestational diabetes mellitus

2021 ◽  
Vol 10 (11) ◽  
pp. 4278
Author(s):  
J. Princy Emil Josephine ◽  
Susan William
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Tertiary Care ◽  
Challenge Test ◽  
Birth Asphyxia ◽  
Fetal Outcome ◽  
Wide Range

Background: India being the diabetic capital of the world, Indian women have a high prevalence of gestational diabetes mellitus (16.5%). It can cause a wide range of complications as well as long term implications in both the mother and fetus. A large proportion of women also progress to become overt diabetics in the future hampering with their quality of life by causing morbidity in various forms. Aim of this study is to evaluate the fetomaternal outcome in women with gestational diabetes mellitus at a tertiary care teaching hospital and the incidence of glucose intolerance in these women during the postpartum period.Methods: All patients attending the antenatal OPD were offered a 75g glucose challenge test and 200 patients diagnosed with GDM were included in the study for a period of one year. Fetomaternal complications were studied and postpartum follow up was done in these patients.Results: Out of these 200 women, 49% delivered via LSCS, 46% via labor naturalis and 5% via instrumental delivery. 59.5% were on insulin and 40.5% were treated with meal plan. Pre-eclampsia complicating pregnancy was seen in 26%, polyhydramnios was encountered in 17.5%, Urinary tract infection in 11%, preterm labour in 8.5% and PROM in 7%. Adverse fetal outcome was seen in 5% of the babies. Birth asphyxia was seen in 7.5%, macrosomia in 13%, 5% of the babies had congenital anomalies. In the postapartum follow up at 6 weeks 22.5% of the study population were glucose intolerant (75 gm OGTT).Conclusions: Early detection and prompt management of this condition can tremendously reduce the short term and long-term complications in both the mother and fetus.

scholarly journals Maternal and foetal outcome in patients of gestational diabetes mellitus

2018 ◽  
Vol 7 (9) ◽  
pp. 3831
Author(s):  
Priyanka Priyanka
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
White Women ◽  
Fetal Outcome ◽  
Intrauterine Death ◽  
Indian Women ◽  
High Prevalence ◽  
Nicu Admission

Background: Indian women have high Prevalence of diabetes and their relative risk of developing gestational diabetes mellitus (GDM) is 11.3 times compared to white women. The metabolic adaptations during pregnancy are designed to maintain a continuous availability of substrate to accommodate the fetal growth. Aims of present study were the antenatal screening of Gestational diabetes mellitus and its pregnancy outcome.Methods: The present study is a type of prospective study in this study 6000 pregnant women were randomly selected for screening irrespective of gestational age and any of the risk factor. All consenting pregnant, who came for first absolute neutrophil count in outpatient department, pregnant women of any parity, and singleton pregnancies were included.Results: Out of 6000 women screened 200 were found positive for GDM. The study indicated that GDM was 3.33%. The incidence of GDM was found to be more in women > 25 years age. Fetal outcome was satisfactory in well controlled GDM, only 7 babies were macrosomic, 13 intrauterine death and 5 still birth, 10 babies required NICU admission for hypoglycemia, respiratory distress syndrome, septicemia.Conclusions: Fetal outcome was satisfactory in well controlled GDM. There was no neonatal mortality. Hence, GDM and its complications are preventable.

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