Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus

2002 ◽  
Vol 39 (3) ◽  
pp. 117-122 ◽  
Author(s):  
H. M. Turk ◽  
A. Sevinc ◽  
C. Camci ◽  
A. Cigli ◽  
S. Buyukberber ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Plasma Lipid ◽  
Antioxidant Enzyme Activities ◽  
Plasma Lipid Peroxidation

A Study of Lipid Peroxidation and Antioxidants in Patients with Type 2 Diabetes Mellitus with and without Neuropathy

2015 ◽  
Vol 3 (1) ◽  
pp. 71
Author(s):  
Sunita Pujar ◽  
Kavitha Hiremath ◽  
LL Pujar ◽  
Neela B Mannangi ◽  
Mahanthesh Bhuthal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Peroxidation ◽  
Type 2 Diabetes Mellitus

scholarly journals Effects of α-Tocopherol and Mixed Tocopherol Supplementation on Markers of Oxidative Stress and Inflammation in Type 2 Diabetes

2007 ◽  
Vol 53 (3) ◽  
pp. 511-519 ◽  
Author(s):  
Jason HY Wu ◽  
Natalie C Ward ◽  
Adeline P Indrawan ◽  
Coral-Ann Almeida ◽  
Jonathan M Hodgson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Ex Vivo ◽  
Controlled Trial ◽  
Antioxidant Enzyme Activities ◽  
Markers Of Oxidative Stress

Abstract Background: Vitamin E isomers may protect against atherosclerosis. The aim of this study was to compare the effects of supplementation with either α-tocopherol (αT) or mixed tocopherols rich in γ-tocopherol (γT) on markers of oxidative stress and inflammation in patients with type 2 diabetes. Methods: In a double-blind, placebo-controlled trial, 55 patients with type 2 diabetes were randomly assigned to receive (500 mg/day) (a) αT, (b) mixed tocopherols, or (c) placebo for 6 weeks. Cellular tocopherols, plasma and urine F2-isoprostanes, erythrocyte antioxidant enzyme activities, plasma inflammatory markers, and ex vivo assessment of eicosanoid synthesis were analyzed pre- and postsupplementation. Results: Neutrophil αT and γT increased (both P <0.001) with mixed tocopherol supplementation, whereas αT (P <0.001) increased and γT decreased (P <0.005) after αT supplementation. Both αT and mixed tocopherol supplementation resulted in reduced plasma F2-isoprostanes (P <0.001 and P = 0.001, respectively) but did not affect 24-h urinary F2-isoprostanes or erythrocyte antioxidant enzyme activities. Neither αT nor mixed tocopherol supplementation affected plasma C-reactive protein, interleukin 6, tumor necrosis factor-α, or monocyte chemoattractant protein-1. Stimulated neutrophil leukotriene B4 production decreased significantly in the mixed tocopherol group (P = 0.02) but not in the αT group (P = 0.15). Conclusions: The ability of tocopherols to reduce systemic oxidative stress suggests potential benefits of vitamin E supplementation in patients with type 2 diabetes. In populations with well-controlled type 2 diabetes, supplementation with either αT or mixed tocopherols rich in γT is unlikely to confer further benefits in reducing inflammation.

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