scholarly journals Effects of seaweed supplementation on blood glucose concentration, lipid profile, and antioxidant enzyme activities in patients with type 2 diabetes mellitus

2008 ◽  
Vol 2 (2) ◽  
pp. 62 ◽  
Author(s):  
Min Sun Kim ◽  
Jung Yun Kim ◽  
Woong Hwan Choi ◽  
Sang Sun Lee
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Glucose Concentration ◽  
Enzyme Activities ◽  
Blood Glucose Concentration ◽  
Antioxidant Enzyme Activities

The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Arina D. Puspitasari ◽  
Hayu Kusuma ◽  
Dinda M.N. Ratri ◽  
Cahyo Wibisono ◽  
Budi Suprapti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Postprandial Blood Glucose ◽  
Premixed Insulin ◽  
Acting Insulin ◽  
Blood Glucose Concentrations

AbstractBackgroundOne of the therapies used to treat type 2 diabetes mellitus (T2DM) disease is combination insulin which consists of rapid-acting insulin and intermediate-acting insulin (premixed). This study aimed to examine the profile of premixed insulin related to blood glucose concentration and to identify the drug interactions due to the combination of premixed insulin with other drugs taken by T2DM patients.MethodsThis study was a prospective observational study with cross-sectional data that were analyzed descriptively. The respondents invited were T2DM patients with or without complication or comorbid disease who received premixed insulin with or without a combination of oral antidiabetic therapy in the Outpatient Unit of Universitas Airlangga Hospital, Surabaya. The research instruments used are data sheet, patient medical record, and fasting and postprandial blood glucose concentration.ResultsA total of 118 patients received premixed insulin therapy, but only 80 patients were included in the inclusion criteria. Based on types of insulin, the combination of 30% aspart and 70% protamine aspart was used by 91.25% T2DM patients, and a combination of 25% insulin lispro and 75% protamine lispro was used by 8.75% T2DM patients. There were 30.3% of patients who could achieve the target of 80–130 mg/dL in fasting blood glucose concentrations, and 35.1% of patients achieved the target of ≤180 mg/dL in postprandial blood glucose concentration. Drug interactions may occur in patients who use premixed insulin with glimepiride, lisinopril, fenofibrate, candesartan, irbesartan, and gemfibrozil.ConclusionsIn this study, premixed insulin have not reached the target of fasting and postprandial blood glucose concentrations in most patients.

scholarly journals Correlation between Obesity and Lipid Profile in Type 2 Diabetes Mellitus Patients at the Endocrine and Metabolic Polyclinic in General Hospital Pirngadi Medan

2019 ◽  
Vol 7 (8) ◽  
pp. 1309-1313 ◽  
Author(s):  
Hendrika Andriana Silitonga ◽  
Jekson Martiar Siahaan ◽  
Endy Juli Anto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Significant Relationship ◽  
Density Lipoprotein ◽  
Obese Patients ◽  
Cholesterol Levels

BACKGROUND: Obesity is a multifactorial disease that is dangerous and is a factor in the emergence of serious diseases such as dyslipidemia, stroke, coronary heart disease and others. In Type 2 Diabetes Mellitus (T2DM) patients there is a disorder of lipid metabolism, namely dyslipidemia. Changes in lipid profile that occurred were an increase in total cholesterol levels, Low-Density Lipoprotein (LDL), and triglycerides, and decreased levels of high-density lipoprotein (HDL). The phenomenon of an increase in T2DM patients in Indonesia caused double mortality in recent decades. AIM: This study was to determine the relationship between obesity and lipid profile in T2DM patients at Pirngadi Medan Hospital in 2018. METHODS: This study was conducted in an observational analytic with a cross-sectional study approach. Fifteen obese patients with T2DM who were treated at the Endocrine and Metabolic Polyclinic in Pirngadi General Hospital Medan from January to December 2018 were recruited into the study sample. RESULT: Based on the analysis using the results of a one-way correlative analytical test showing that there was a positive correlation between obesity and total cholesterol levels (r = 0.209; p = 0.455) and LDL levels (r = 0.335; p = 0.222) but not significant. There was a negative correlation between obesity and HDL levels (r = -0.072; p = 0.798) and triglyceride levels (r = -0.025; p = 0.930) but not significant. There was no significant relationship between obesity and blood glucose levels (r = 0.463; p = 0.082). This study concluded that there was no significant relationship between obese patients and lipid profiles in T2DM patients. CONCLUSION: Obesity positively correlates with blood glucose level, but its correlation with a lipid profile is not reliable.

scholarly journals Type 2 Diabetes Mellitus: A Pathophysiologic Perspective

2021 ◽  
Vol 8 ◽  
Author(s):  
Eric C. Westman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Concentration ◽  
Elevated Blood ◽  
Insulin Levels ◽  
Blood Insulin ◽  
Average Adult

Type 2 Diabetes Mellitus (T2DM) is characterized by chronically elevated blood glucose (hyperglycemia) and elevated blood insulin (hyperinsulinemia). When the blood glucose concentration is 100 milligrams/deciliter the bloodstream of an average adult contains about 5–10 grams of glucose. Carbohydrate-restricted diets have been used effectively to treat obesity and T2DM for over 100 years, and their effectiveness may simply be due to lowering the dietary contribution to glucose and insulin levels, which then leads to improvements in hyperglycemia and hyperinsulinemia. Treatments for T2DM that lead to improvements in glycemic control and reductions in blood insulin levels are sensible based on this pathophysiologic perspective. In this article, a pathophysiological argument for using carbohydrate restriction to treat T2DM will be made.

scholarly journals Short-Term Consumption of Probiotic Yogurt Improved HDL-C of Type 2 Diabetes Mellitus Patients: A Double-Blind Randomized Controlled Trial

2019 ◽  
Vol 26 (4) ◽  
pp. 381-392
Author(s):  
Lily Arsanti Lestari ◽  
Dian Ratnasari ◽  
Elsa Fairuz Azizah ◽  
Ivana Noor Farida ◽  
Farah Nuriannisa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Fasting Blood Glucose ◽  
Probiotic Yogurt

Abstract Background and aims: Cardiovascular disease is the main complication and cause of morbidity and mortality in type 2 diabetes mellitus (T2DM) patients. The main cause of complication in T2DM is oxidative stress caused by insulin resistance, hence it can increase lipid profiles (cholesterol, LDL, and triglycerides) which exacerbates endothelial dysfunction. Among various functional foods with antioxidant effects, probiotic foods have been reported to suppress oxidative stress, and also improve the fasting blood glucose (FBG) and lipid profile in patients with T2DM. The aim of this clinical trial is to study the effects of probiotics and conventional yogurt on FBG and lipid profile in patients with T2DM. Material and method: Thirty-eight patients with T2DM, aged 30 to 60 years old, were assigned to two groups in this randomized, doubleblind, controlled clinical trial. The subjects in the intervention group consumed 100 ml/day probiotic yogurt containing Lactobacillus acidophilus La-5 and Bifidobacterium lactis BB-12, whereas subjects in the control group consumed 100 ml/day conventional yogurt for four weeks. Anthropometric indices, dietary intake, physical activity, serum FBG, and lipid profile were evaluated at the beginning and end of the intervention. Results: Consumption of 100 mL/day conventional yogurt could significantly reduce the fasting blood glucose (FBG) level, whereas probiotic yogurt could not reduce FBG significantly. Although the total cholesterol and triglyceride were not improved after yogurt consumption, both type of yogurt could improve HDL-C level. Conclusion: Both conventional yogurt or probiotic yogurt could be used as functional food since it improved the HDL-C in type 2 DM patients.

scholarly journals EFFECT OF SITAGLIPTIN ON GLYCEMIC CONTROL AND BEYOND - IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 11 (8) ◽  
pp. 316
Author(s):  
Ramya Ravichandar ◽  
Aravind Anapathoor Nagarajan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Plasma Glucose ◽  
Fasting Blood Glucose ◽  
Postprandial Plasma Glucose

Objective: The objective of the study was to assess the pleiotropic effects of Sitagliptin as add-on therapy to the conventional antidiabetic drugs.Methods: This was designed as a prospective study. 140 patients with type 2 diabetes mellitus (T2DM) whose glycated hemoglobin (HbA1c) was >7% despite receiving education on diet and exercise and/or medications were enrolled in this study. Sitagliptin (100 mg) was administered once a day orally for 6 months as an add-on therapy with the conventional antidiabetic drugs. The outcome of the therapy was assessed on the level of improvement in the fasting plasma glucose, postprandial plasma glucose, HbA1c levels, lipid profile, body mass index, blood pressure, and albuminuria in the third and 6th month when compared to the first visit.Results: After 6 months of treatment with Sitagliptin, fasting blood glucose levels significantly reduced (202.6±49.21 to 186.1±50.14, p=0.029) as well as HbA1c (9.5±1.27 to 9.1±1.28, p=0.016). There was a statistically significant (p<0.001) reduction of blood pressure, cholesterol, and urinary albumin-creatinine ratio progressively.Conclusion: Sitagliptin has a significant effect on lipid profile, blood pressure and albuminuria in addition to its effect on blood glucose profile and HbA1c without many side effects, in patients with T2DM.

Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽  
2021 ◽  
Author(s):  
Marwa Matboli ◽  
Doaa Ibrahim ◽  
Amany H Hasanin ◽  
Mohamed Kamel Hassan ◽  
Eman K Habib ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Light And Electron Microscopy ◽  
Lipid Profiles ◽  
Mirna Regulation ◽  
Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and  WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

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