Folic acid-conjugated chromium(III) doped nanoparticles consisting of mixed oxides of zinc, gallium and tin, and possessing near-infrared and long persistent phosphorescence for targeted imaging of cancer cells

2015 ◽  
Vol 182 (9-10) ◽  
pp. 1827-1834 ◽  
Author(s):  
Yang Li ◽  
Ruchun Chen ◽  
Yiyang Li ◽  
Kaniyarakkal Sharafudeen ◽  
Shijian Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Near Infrared ◽  
Mixed Oxides ◽  
Targeted Imaging

Gold nanoparticle-enhanced near infrared fluorescent nanocomposites for targeted bio-imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Hao Cheng ◽  
Chuanxi Wang ◽  
Zhenzhu Xu ◽  
Huihui Lin ◽  
Chi Zhang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Near Infrared ◽  
Water Solubility ◽  
Imaging Agents ◽  
Nir Fluorescence ◽  
Target Imaging ◽  
Bio Imaging ◽  
Low Toxicity

Folic acid-conjugated nanocomposites with NIR fluorescence, water-solubility, and low toxicity are prepared and used as target-imaging agents for cancer cells.

Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells

2018 ◽  
Vol 262 ◽  
pp. 444-451 ◽  
Author(s):  
Jiali Qian ◽  
Feifei Quan ◽  
Fengjiao Zhao ◽  
Chengxin Wu ◽  
Zhaoyan Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Carbon Dots ◽  
Folate Receptor ◽  
Targeted Imaging ◽  
Aconitic Acid

Triblock near-infrared fluorescent polymer semiconductor nanoparticles for targeted imaging

2017 ◽  
Vol 5 (23) ◽  
pp. 5685-5692 ◽  
Author(s):  
Jiahui Zhang ◽  
Yiming Huang ◽  
Dongsheng Wang ◽  
Alyssa C. Pollard ◽  
Zhuo (Georgia) Chen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Near Infrared ◽  
Triblock Copolymers ◽  
Folate Receptor ◽  
Semiconductor Nanoparticles ◽  
Targeted Imaging ◽  
Polymer Semiconductor ◽  
Fluorescent Polymer ◽  
Self Assembled

Self-assembled nanoparticles of triblock copolymers incorporating a NIR-emitting fluorophore and folic acid specifically label folate receptor-positive cells.

scholarly journals PEGylated-folic acid–modified black phosphorus quantum dots as near-infrared agents for dual-modality imaging-guided selective cancer cell destruction

Nanophotonics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 2425-2435 ◽  
Author(s):  
Jing Wang ◽  
Dong Liang ◽  
Zehua Qu ◽  
Ivan M. Kislyakov ◽  
Valery M. Kiselev ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Folic Acid ◽  
Cancer Cells ◽  
Near Infrared ◽  
Processing System ◽  
Black Phosphorus ◽  
Optical Absorbance ◽  
Present Design ◽  
Black Phosphorus Quantum Dots

AbstractBiological systems have high transparence to 700–1100-nm near-infrared (NIR) light. Black phosphorus quantum dots (BPQDs) have high optical absorbance in this spectrum. This optical property of BPQDs integrates both diagnostic and therapeutic functions together in an all-in-one processing system in cancer theranostic approaches. In the present study, BPQDs were synthesized and functionalized by targeting moieties (PEG-NH2-FA) and were further loaded with anticancer drugs (doxorubicin) for photodynamic–photothermal–chemotherapy. The precise killing of cancer cells was achieved by linking BPQDs with folate moiety (folic acid), internalizing BPQDs inside cancer cells with folate receptors and NIR triggering, without affecting the receptor-free cells. These in vitro experiments confirm that the agent exhibited an efficient photokilling effect and a light-triggered and heat-induced drug delivery at the precise tumor sites. Furthermore, the nanoplatform has good biocompatibility and effectively obliterates tumors in nude mice, showing no noticeable damages to noncancer tissues. Importantly, this nanoplatform can inhibit tumor growth through visualized synergistic treatment and photoacoustic and photothermal imaging. The present design of versatile nanoplatforms can allow for the adjustment of nanoplatforms for good treatment efficacy and multiplexed imaging, providing an innovation for targeted tumor treatment.

Fluorescent small Au nanodots prepared from large Ag nanoparticles for targeting and imaging cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 52088-52094 ◽  
Author(s):  
Yuanqing Sun ◽  
Dandan Wang ◽  
Lin Xu ◽  
Tianxin Zhao ◽  
Chuanxi Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Ag Nanoparticles ◽  
Targeted Imaging ◽  
Potential Applications ◽  
Au Nanodots

The fluorescent gold nanodots are conjugated with folic acid, which provides them with potential applications in targeted imaging of cancer cells.

scholarly journals Use in vitro of Gold Nanoparticles Functionalized with Folic Acid as a Photothermal Agent on Treatment of HeLa Cells

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Linda Bertel Garay ◽  
Fernando Martínez Ortega ◽  
Stelia Carolina Méndez-Sanchez
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
Molar Ratio ◽  
Functionalized Gold Nanoparticles ◽  
Dose Dependent

<p>Folic acid (FA) is used as a recognition molecule to achieve selective internalization in cancer cells. Here functionalized gold nanoparticles with folic acid (AuNP-FA) are proposed as suitable therapeutic agents for cervix cancer cells by photothermal damage. The functionalized gold nanoparticles with folic acid were synthesized by mixing hydrogen tetrachloroaurate with folic acid in a molar ratio of 0.56/1 under radiation of mercury lamp (λ<sub>max</sub>=254 nm). HeLa cells were incubated with AuNP-FA during 48 h, then were irradiated and the cytotoxicity was analyzed 12 h after irradiation. The AuNP-FA were dose-dependent cytotoxic under irradiation and not cytotoxic in the absence of radiation. The viability of cancer cells treated with functionalized and non-functionalized gold nanoparticles (AuNPs), with and without near infrared light at 808 nm, was measured by MTT assays. This work provides useful guidance toward the synthesis of biocompatible nanomaterials for biological applications.</p>

6‐Triphenylphosphinehexanoic Acid Conjugated Near‐Infrared Persistent Luminescence Nanoprobe for Autofluorescence‐Free Targeted Imaging of Mitochondria in Cancer Cells

ChemNanoMat ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 427-434
Author(s):  
Yu‐Bin Su ◽  
Xu Zhao ◽  
Li‐Jian Chen ◽  
Hai‐Long Qian ◽  
Xiu‐Ping Yan
Keyword(s):  
Cancer Cells ◽  
Near Infrared ◽  
Targeted Imaging ◽  
Persistent Luminescence

Upconversion Nanoparticles Y2O3 and Gd2O3 Co-Doped with Er3+ and Yb3+ with Aminosilane-Folic Acid Functionalization for Breast and Cervix Cancer Cells Detection

MRS Advances ◽  
2017 ◽  
Vol 2 (52) ◽  
pp. 2983-2988 ◽  
Author(s):  
D. Chávez-García ◽  
K. Juárez-Moreno ◽  
G.A. Hirata
Keyword(s):  
Particle Size ◽  
Folic Acid ◽  
Cancer Cells ◽  
Near Infrared ◽  
Colorimetric Assay ◽  
Rare Earth Ions ◽  
Upconversion Nanoparticles ◽  
Breast Cancers ◽  
Transmission Electron ◽  
Cervical Cancer Cells

ABSTRACTThe upconversion nanoparticles (UCNPs) possess the ability to absorb near infrared energy (980 nm) and upconvert it to emit in the visible spectra. In this research, the UNCPs emit in red (660 nm) due to the electronic transitions between two rare earth ions: Er3+ and Yb3+, this process is called energy transfer upconversion (ETU). The UCNPs were functionalized with aminosilanes and folic acid receptors (UCNP-FR) and analyzed by transmission electron microscopy, Fourier transform infrared spectroscopy and luminescence measurements. UCNPs-FR of Y2O3 have a particle size of 70 ± 10 nm and the Gd2O3 have a 50 ± 10 nm particle size. Both showed a good luminescence spectrum in comparison with the bare ones. Cytotoxicity of different amounts between 0.001 µg/ml to 1 µg/ml of bare and functionalized UCNPs was measured with the colorimetric assay MTT in three cancer cell lines: human cervical adenocarcinoma (HeLa), human breast cancer cells MB-MDA-231. Some concentrations of bare UCNPs were cytotoxic for cancer cells; however after their functionalization they resulted to be non-cytotoxic. The functionalized UCNPs were able to bind to folate receptors which are overexpressed in cervical and breast cancers cells. It was demonstrated by confocal microscopy, that the functionalized UCNPs were internalized into the cancer cells, confirming that they can be used as biolabels for breast and cervical cancer cells.

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