Triblock near-infrared fluorescent polymer semiconductor nanoparticles for targeted imaging

2017 ◽  
Vol 5 (23) ◽  
pp. 5685-5692 ◽  
Author(s):  
Jiahui Zhang ◽  
Yiming Huang ◽  
Dongsheng Wang ◽  
Alyssa C. Pollard ◽  
Zhuo (Georgia) Chen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Near Infrared ◽  
Triblock Copolymers ◽  
Folate Receptor ◽  
Semiconductor Nanoparticles ◽  
Targeted Imaging ◽  
Polymer Semiconductor ◽  
Fluorescent Polymer ◽  
Self Assembled

Self-assembled nanoparticles of triblock copolymers incorporating a NIR-emitting fluorophore and folic acid specifically label folate receptor-positive cells.

Aconitic acid derived carbon dots: Conjugated interaction for the detection of folic acid and fluorescence targeted imaging of folate receptor overexpressed cancer cells

2018 ◽  
Vol 262 ◽  
pp. 444-451 ◽  
Author(s):  
Jiali Qian ◽  
Feifei Quan ◽  
Fengjiao Zhao ◽  
Chengxin Wu ◽  
Zhaoyan Wang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Carbon Dots ◽  
Folate Receptor ◽  
Targeted Imaging ◽  
Aconitic Acid

Folic acid-conjugated chromium(III) doped nanoparticles consisting of mixed oxides of zinc, gallium and tin, and possessing near-infrared and long persistent phosphorescence for targeted imaging of cancer cells

2015 ◽  
Vol 182 (9-10) ◽  
pp. 1827-1834 ◽  
Author(s):  
Yang Li ◽  
Ruchun Chen ◽  
Yiyang Li ◽  
Kaniyarakkal Sharafudeen ◽  
Shijian Liu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Near Infrared ◽  
Mixed Oxides ◽  
Targeted Imaging

scholarly journals Targeted Nanoparticles for Fluorescence Imaging of Folate Receptor Positive Tumors

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1651
Author(s):  
Aimee J. Marko ◽  
Ballav M. Borah ◽  
Kevin E. Siters ◽  
Joseph R. Missert ◽  
Anurag Gupta ◽  
...  
Keyword(s):  
Folic Acid ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Folate Receptor ◽  
Cyanine Dye ◽  
Target Specificity ◽  
Nir Fluorescence ◽  
Positive Breast Cancer

This report presents the synthesis and folate receptor target-specificity of amino-functionalized polyacrylamide nanoparticles (AFPAA NPs) for near-infrared (NIR) fluorescence imaging of cancer. For the synthesis of desired nano-constructs, the AFPAA NPs (hereafter referred to as NPs) were reacted with a NIR cyanine dye (CD) bearing carboxylic acid functionality by following our previously reported approach, and the resulting conjugate (NP-CD) on further reaction with folic acid (FA) resulted in a new nano-construct, FA-NP-CD, which demonstrated significantly higher uptake in folate receptor-positive breast cancer cells (KB+) and in folate receptor over-expressed tumors in vivo. The target-specificity of these nanoparticles was further confirmed by inhibition assay in folate receptor-positive (KB+) and -negative (HT-1080) cell lines. To show the advantages of polyacrylamide (PAA)-based NPs in folate receptor target-specificity, the CD used in preparing the FA-NP-CD construct was also reacted with folic acid alone and the synthetic conjugate (CD-FA) was also investigated for its target-specificity. Interestingly, in contrast to NPs (FA-NP-CD), the CD-FA conjugate did not show any significant in vitro or in vivo specificity toward folate receptors, showing the advantages of PAA-based nanotechnology in delivering the desired agent to tumor cells.

Novel multifunctional nano-hybrid polyhedral oligomeric silsesquioxane-based molecules with high cell permeability: molecular design and application for diagnosis and treatment of tumors

Nanoscale ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 2982-2994
Author(s):  
Gang Wei ◽  
Kezhen Zhang ◽  
Yuanlong Gu ◽  
Shanyi Guang ◽  
Jihong Feng ◽  
...  
Keyword(s):  
Folic Acid ◽  
Molecular Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Cell Permeability ◽  
Targeted Imaging ◽  
High Cell ◽  
One Pot ◽  
Peg 400 ◽  
Multifunctional Molecules ◽  
Oligomeric Silsesquioxane

Octathiol POSS was used to connect PEG-400, hexene, folic acid, fluorescein, and thioguanine using a simple and efficient photo-initiated one-pot method to prepare multifunctional molecules, which have targeted imaging and therapeutic functions.

A small bandgap (3E,7E)-3,7-bis(2-oxoindolin-3-ylidene)benzo[1,2-b:4,5-b′]difuran-2,6(3H,7H)-dione (IBDF) based polymer semiconductor for near-infrared organic phototransistors

2017 ◽  
Vol 5 (46) ◽  
pp. 12163-12171 ◽  
Author(s):  
Yinghui He ◽  
Jesse T. E. Quinn ◽  
Dongliang Hou ◽  
Jenner H.L. Ngai ◽  
Yuning Li
Keyword(s):  
Band Gap ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Polymer Semiconductor ◽  
Donor Acceptor ◽  
Small Band

A novel small bandgap donor–acceptor polymer with a very small band gap of 0.95 eV shows promising photoresponse under near infrared light in phototransistors.

Gold nanoparticle-enhanced near infrared fluorescent nanocomposites for targeted bio-imaging

RSC Advances ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Hao Cheng ◽  
Chuanxi Wang ◽  
Zhenzhu Xu ◽  
Huihui Lin ◽  
Chi Zhang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Near Infrared ◽  
Water Solubility ◽  
Imaging Agents ◽  
Nir Fluorescence ◽  
Target Imaging ◽  
Bio Imaging ◽  
Low Toxicity

Folic acid-conjugated nanocomposites with NIR fluorescence, water-solubility, and low toxicity are prepared and used as target-imaging agents for cancer cells.

Folic acid-conjugated green luminescent carbon dots as a nanoprobe for identifying folate receptor-positive cancer cells

Talanta ◽  
2018 ◽  
Vol 183 ◽  
pp. 39-47 ◽  
Author(s):  
Junli Zhang ◽  
Xuewei Zhao ◽  
Ming Xian ◽  
Chuan Dong ◽  
Shaomin Shuang
Keyword(s):  
Folic Acid ◽  
Cancer Cells ◽  
Carbon Dots ◽  
Folate Receptor
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