In-tube stir bar sorptive extraction based on 3-aminopropyl triethoxysilane surface-modified Ce-doped ZnAl layered double hydroxide thin film for determination of nonsteroidal anti-inflammatory drugs in saliva samples

2020 ◽  
Vol 187 (9) ◽  
Author(s):  
Mahsa Torabi Mirzaee ◽  
Shahram Seidi ◽  
Yasaman Razeghi ◽  
Mahshid Manouchehri ◽  
Maryam Shanehsaz
Keyword(s):  
Thin Film ◽  
Layered Double Hydroxide ◽  
Stir Bar Sorptive Extraction ◽  
Sorptive Extraction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Surface Modified ◽  
Double Hydroxide

scholarly journals Synthesis and Application of Magnetic@layered Double Hydroxide as an Anti-Inflammatory Drugs Nanocarrier

2020 ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background: Magnetic nanocomposites with a core-shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (abbreviated PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

Determination of quercetin via thin film microextraction using the in situ growth of Co–Al-layered double hydroxide nanosheets on an electrochemically anodized aluminum substrate followed by HPLC

2020 ◽  
Vol 12 (6) ◽  
pp. 799-806
Author(s):  
Faezeh Alipour ◽  
Jahan Bakhsh Raoof ◽  
Milad Ghani
Keyword(s):  
Thin Film ◽  
Layered Double Hydroxide ◽  
Aluminum Substrate ◽  
In Situ Growth ◽  
Anodized Aluminum ◽  
Double Hydroxide

The present study explains the in situ growth of Co–Al layered double hydroxide coated on an anodized aluminum substrate for thin film microextraction (TFME) approach.

scholarly journals Synthesis and Application of Magnetic@Layered Double Hydroxide Multicore-Shell Nanostructure as a Novel Anti-Inflammatory Drugs Nanocarrier

2020 ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background: magnetic nanocomposites with a core-shell nanostructure has huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experimentand is used as novel drug nanocarrier.Methods: Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and in following, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as the anti-inflammatory drugs by using exchange anion experiment, the basal spacing of synthesized layered double hydroxides were compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results: The results indicated Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs by bridging bidentate interaction. Besides, in vitro drug release experiments in pH 7.4, Phosphate-buffered saline (abbreviated PBS) showed the constant release profiles with Ibuprofen and diclofenac as model drugs with different lipophilicity and water solubility and size and steric effect. Conclusions: The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity and high thermal stability. We confirm, which Fe3O4@LDH multicore-shell nanostructure will have potential application for constant drug delivery.

scholarly journals Synthesis and application of magnetic@layered double hydroxide as an anti-inflammatory drugs nanocarrier

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Vahid Yousefi ◽  
Vahideh Tarhriz ◽  
Shirin Eyvazi ◽  
Azita Dilmaghani
Keyword(s):  
Layered Double Hydroxide ◽  
Water Solubility ◽  
Chemical Properties ◽  
Basal Spacing ◽  
Magnetic Nanospheres ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Double Hydroxide ◽  
Physical And Chemical

Abstract Background Magnetic nanocomposites with a core–shell nanostructure have huge applications in different sciences especially in the release of the drugs, because of their exclusive physical and chemical properties. In this research, magnetic@layered double hydroxide multicore@shell nanostructure was synthesized by the facile experiment and is used as novel drug nanocarrier. Methods Magnetic nanospheres were synthesized by a facile one-step solvothermal route, and then, layered double hydroxide nanoflakes were prepared on the magnetic nanospheres by coprecipitation experiment. The synthesized nanostructures were characterized by FTIR, XRD, SEM, VSM, and TEM, respectively. After intercalation with Ibuprofen and Diclofenac as anti-inflammatory drugs and using exchange anion experiment, the basal spacing of synthesized layered double hydroxides was compared with brucite nanosheets from 0.48 nm to 2.62 nm and 2.22 nm, respectively. Results The results indicated that Ibuprofen and Diclofenac were successfully intercalated into the interlay space of LDHs via bridging bidentate interaction. In addition, in-vitro drug release experiments in pH 7.4, phosphate-buffered saline (PBS) showed constant release profiles with Ibuprofen and Diclofenac as model drugs with different lipophilicity, water solubility, size, and steric effect. Conclusion The Fe3O4@LDH-ibuprofen and Fe3O4@LDH-diclofenac had the advantage of the strong interaction between the carboxyl groups with higher trivalent cations by bridging bidentate, clarity, and high thermal stability. It is confirmed that Fe3O4@LDH multicore-shell nanostructure may have potential application for constant drug delivery.

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