Brain arteriovenous malformations in elderly patients: clinical features and treatment outcome

2015 ◽  
Vol 157 (10) ◽  
pp. 1645-1654 ◽  
Author(s):  
Xianzeng Tong ◽  
Jun Wu ◽  
Fuxin Lin ◽  
Yong Cao ◽  
Yuanli Zhao ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Elderly Patients ◽  
Clinical Features ◽  
Arteriovenous Malformations ◽  
Brain Arteriovenous Malformations

Clinical features and management of brain arteriovenous malformations in elderly patients

2004 ◽  
Vol 146 (10) ◽  
pp. 1091-1098 ◽  
Author(s):  
H. Hashimoto ◽  
J. Iida ◽  
S. Kawaguchi ◽  
T. Sakaki
Keyword(s):  
Elderly Patients ◽  
Clinical Features ◽  
Arteriovenous Malformations ◽  
Brain Arteriovenous Malformations

scholarly journals Determinants of Staged Endovascular and Surgical Treatment Outcome of Brain Arteriovenous Malformations

Stroke ◽  
2005 ◽  
Vol 36 (11) ◽  
pp. 2431-2435 ◽  
Author(s):  
Andreas Hartmann ◽  
Henning Mast ◽  
Jay P. Mohr ◽  
John Pile-Spellman ◽  
E. Sander Connolly ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Surgical Treatment ◽  
Arteriovenous Malformations ◽  
Brain Arteriovenous Malformations

Clinical features and treatment outcome of very elderly patients over 80 years old with multiple myeloma: comparison with patients in different age groups in the era of novel agents

2015 ◽  
Vol 57 (1) ◽  
pp. 110-115 ◽  
Author(s):  
Kosei Matsue ◽  
Yuya Matsue ◽  
Manabu Fujisawa ◽  
Kota Fukumoto ◽  
Yasuhito Suehara ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Treatment Outcome ◽  
Elderly Patients ◽  
Clinical Features ◽  
Age Groups ◽  
Novel Agents ◽  
Very Elderly

scholarly journals Radiomics Analysis for Predicting Epilepsy in Patients With Unruptured Brain Arteriovenous Malformations

2021 ◽  
Vol 12 ◽  
Author(s):  
Shaozhi Zhao ◽  
Qi Zhao ◽  
Yuming Jiao ◽  
Hao Li ◽  
Jiancong Weng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Features ◽  
Arteriovenous Malformations ◽  
Clinical Usefulness ◽  
Clinical Risk Factors ◽  
Combined Model ◽  
Clinical Model ◽  
Clinical Risk ◽  
Brain Arteriovenous Malformations ◽  
Tof Mra

Objectives: To investigate the association between radiomics features and epilepsy in patients with unruptured brain arteriovenous malformations (bAVMs) and to develop a prediction model based on radiomics features and clinical characteristics for bAVM-related epilepsy.Methods: This retrospective study enrolled 176 patients with unruptured bAVMs. After manual lesion segmentation, a total of 858 radiomics features were extracted from time-of-flight magnetic resonance angiography (TOF-MRA). A radiomics model was constructed, and a radiomics score was calculated. Meanwhile, the demographic and angioarchitectural characteristics of patients were assessed to build a clinical model. Incorporating the radiomics score and independent clinical risk factors, a combined model was constructed. The performance of the models was assessed with respect to discrimination, calibration, and clinical usefulness.Results: The clinical model incorporating 3 clinical features had an area under the curve (AUC) of 0.71. Fifteen radiomics features were used to build the radiomics model, which had a higher AUC of 0.78. Incorporating the radiomics score and clinical risk factors, the combined model showed a favorable discrimination ability and calibration, with an AUC of 0.82. Decision curve analysis (DCA) demonstrated that the combined model outperformed the clinical model and radiomics model in terms of clinical usefulness.Conclusions: The radiomics features extracted from TOF-MRA were associated with epilepsy in patients with unruptured bAVMs. The radiomics-clinical nomogram, which was constructed based on the model incorporating the radiomics score and clinical features, showed favorable predictive efficacy for bAVM-related epilepsy.

scholarly journals Surgical selection and outcomes among elderly patients with brain arteriovenous malformations

2020 ◽  
Vol 49 (4) ◽  
pp. E9
Author(s):  
Jan-Karl Burkhardt ◽  
Ethan A. Winkler ◽  
Joshua S. Catapano ◽  
Robert F. Spetzler ◽  
Michael T. Lawton
Keyword(s):  
Elderly Patients ◽  
Arteriovenous Malformations ◽  
Age Groups ◽  
The Elderly ◽  
Preoperative Embolization ◽  
Neurological Outcomes ◽  
Brain Arteriovenous Malformations ◽  
Group 2 ◽  
Brain Avms ◽  
Group 1

OBJECTIVEStudies of resection of brain arteriovenous malformations (AVMs) in the elderly population are scarce. This study examined factors influencing patient selection and surgical outcome among elderly patients.METHODSPatients 65 years of age and older who underwent resection of an unruptured or ruptured brain AVM treated by two surgeons at two centers were identified. Patient demographic characteristics, AVM characteristics, clinical presentation, and outcomes measured using the modified Rankin Scale (mRS) were analyzed. For subgroup analyses, patients were dichotomized into two age groups (group 1, 65–69 years old; group 2, ≥ 70 years old).RESULTSOverall, 112 patients were included in this study (group 1, n = 61; group 2, n = 51). Most of the patients presented with hemorrhage (71%), a small nidus (< 3 cm, 79%), and a low Spetzler-Martin (SM) grade (grade I or II, 63%) and were favorable surgical candidates according to the supplemented SM grade (supplemented SM grade < 7, 79%). A smaller AVM nidus was statistically significantly more likely to be present in patients with infratentorial AVMs (p = 0.006) and with a compact AVM nidus structure (p = 0.02). A larger AVM nidus was more likely to be treated with preoperative embolization (p < 0.001). Overall outcome was favorable (mRS scores 0–3) in 71% of the patients and was statistically independent from age group or AVM grading. Patients with ruptured AVMs at presentation had significantly better preoperative mRS scores (p < 0.001) and more favorable mRS scores at the last follow-up (p = 0.04) than patients with unruptured AVMs.CONCLUSIONSOutcomes were favorable after AVM resection in both groups of patients. Elderly patients with brain AVMs treated microsurgically were notable for small nidus size, AVM rupture, and low SM grades. Microsurgical resection is an important treatment modality for elderly patients with AVMs, and supplemented SM grading is a useful tool for the selection of patients who are most likely to achieve good neurological outcomes after resection.

Clinical Features of Superficially Located Brain Arteriovenous Malformations with Transdural Arterial Communication

2016 ◽  
Vol 41 (3-4) ◽  
pp. 204-210 ◽  
Author(s):  
Hae-Won Koo ◽  
Kyung-Il Jo ◽  
Je-Young Yeon ◽  
Keon Ha Kim ◽  
Pyoung Jeon ◽  
...  
Keyword(s):  
Clinical Features ◽  
Arteriovenous Malformations ◽  
Chronic Headache ◽  
Prognostic Significance ◽  
Clinical Findings ◽  
Older Age ◽  
Brain Arteriovenous Malformations ◽  
Radiologic Findings ◽  
Brain Avm ◽  
Brain Avms

Background: Contrary to deeply located brain arteriovenous malformations (AVMs), superficially located AVMs are more likely to have transdural arterial communications (TACs). However, the clinical and radiologic characteristics of patients presenting with AVMs and TACs are poorly understood. The purpose of this study is to determine whether clinicoradiological features of cerebral AVMs differ according to TAC. Methods: Between 2002 and 2012, 438 consecutive patients with a brain AVM were treated in our hospital. Among them were 124 patients with superficially located brain AVMs who met the inclusion and exclusion criteria of our study. We retrospectively reviewed the clinicoradiological features of their TACs to explore the variation in characteristics. Results: Thirty-two of the 124 patients with a superficially located AVM (25.8%) had TAC. Radiologic findings of brain AVM images with TAC showed that TAC occurred significantly more frequently among larger AVMs (with vs. without TAC, 11.2 vs. 4.0 ml) and among diffuse AVMs (56.3 vs. 28.3%, p = 0.004). Clinical findings indicate that TAC was associated with chronic headache (43.8 vs. 12.0%, p < 0.001) and older age (43.1 vs. 36.6 years, p = 0.037). Conclusions: Brain AVM with TAC seems to be accompanied by distinctive clinical features, such as chronic headache and older age. Larger size and diffuseness of the AVM were also associated with TAC. Findings from this study and the prognostic significance of TAC should be further explored in a large prospective study.

Transvenous embolization of brain arteriovenous malformations: a systematic review and meta-analysis

2019 ◽  
Vol 63 (4) ◽  
Author(s):  
Yi-Bin Fang ◽  
Jun-Soo Byun ◽  
Jian-Min Liu ◽  
Timo Krings ◽  
Vitor M. Pereira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Arteriovenous Malformations ◽  
Meta Analysis ◽  
Transvenous Embolization ◽  
Brain Arteriovenous Malformations
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