Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread

2010 ◽  
Vol 155 (5) ◽  
pp. 789-793 ◽  
Author(s):  
Sonja Schmid ◽  
Philippe Metz ◽  
Christine M. A. Prat ◽  
Daniel Gonzalez-Dunia ◽  
Martin Schwemmle
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Disease Virus ◽  
Borna Disease Virus ◽  
Viral Spread ◽  
Kinase C ◽  
P Protein ◽  
Borna Disease

scholarly journals Borna Disease Virus P-protein Is Phosphorylated by Protein Kinase Cε and Casein Kinase II

1997 ◽  
Vol 272 (35) ◽  
pp. 21818-21823 ◽  
Author(s):  
Martin Schwemmle ◽  
Bishnu De ◽  
Licheng Shi ◽  
Amiya Banerjee ◽  
W. Ian Lipkin
Keyword(s):  
Protein Kinase ◽  
Disease Virus ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Borna Disease Virus ◽  
P Protein ◽  
Borna Disease

2133-P: Protein Kinase C Delta Mediates Cytokine-Induced Apoptosis in the Pancreatic Beta Cell

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2133-P
Author(s):  
NIKKI L. FARNSWORTH ◽  
ROBERT A. PISCOPIO ◽  
RICHARD K. BENNINGER
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Protein Kinase C Delta ◽  
Kinase C ◽  
P Protein ◽  
Induced Apoptosis

scholarly journals Targeted disruption of PKC from AKAP Signaling Complexes

2021 ◽  
Author(s):  
Ameya J. Limaye ◽  
George N. Bendzunas ◽  
Eileen Kennedy
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Targeted Disruption ◽  
Physiological Processes ◽  
Kinase C ◽  
P Protein

Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide array of signaling pathways and physiological processes. Protein-protein interactions involving PKC and its...

scholarly journals CD8+ T Lymphocytes Mediate Borna Disease Virus-Induced Immunopathology Independently of Perforin

2001 ◽  
Vol 75 (21) ◽  
pp. 10460-10466 ◽  
Author(s):  
Jürgen Hausmann ◽  
Karin Schamel ◽  
Peter Staeheli
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Disease Virus ◽  
Target Cells ◽  
Wild Type ◽  
Pathogenic Potential ◽  
Borna Disease Virus ◽  
Viral Spread ◽  
Deficient Mice ◽  
Borna Disease

ABSTRACT Perforin-mediated lysis of target cells is the major antiviral effector mechanism of CD8+ T lymphocytes. We have analyzed the role of perforin in a mouse model for CD8+T-cell-mediated central nervous system (CNS) immunopathology induced by Borna disease virus. When a defective perforin gene was introduced into the genetic background of the Borna disease-susceptible mouse strain MRL, the resulting perforin-deficient mice developed strong neurological disease in response to infection indistinguishable from that of their perforin-expressing littermates. The onset of disease was slightly delayed. Brains of diseased perforin-deficient mice showed similar amounts and a similar distribution of CD8+ T cells as wild-type animals. Perforin deficiency had no impact on the kinetics of viral spread through the CNS. Unlike brain lymphocytes from diseased wild-type mice, lymphocytes from perforin-deficient MRL mice showed no in vitro cytolytic activity towards target cells expressing the nucleoprotein of Borna disease virus. Taken together, these results demonstrate that CD8+ T cells mediate Borna disease independent of perforin. They further suggest that the pathogenic potential of CNS-infiltrating CD8+ T cells does not primarily reside in their lytic activity but rather in other functions.

Fluorescence Resonance Energy Transfer-based Screening for Protein Kinase C Ligands Using 6-Methoxynaphthalene-labeled 1,2-Diacylglycerol-lactones

2021 ◽  
Author(s):  
Kohei Tsuji ◽  
Takahiro Ishii ◽  
T Kobayakawa ◽  
Nami Ohashi ◽  
Wataru Nomura ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Resonance Energy Transfer ◽  
Signal Transduction Pathway ◽  
Resonance Energy ◽  
Alzheimer Type Dementia ◽  
Kinase C ◽  
P Protein ◽  
Cellular Signal ◽  
Cellular Signal Transduction Pathway

Protein kinase C (PKC) is associated with a central cellular signal transduction pathway and disorders such as cancer and Alzheimer-type dementia and is therefore a target for treatment of these...

Synthesis and protein kinase C (PKC)-C1 domain binding properties of diacyltetrol based anionic lipids

2014 ◽  
Vol 10 (11) ◽  
pp. 3002-3013 ◽  
Author(s):  
Narsimha Mamidi ◽  
Subhankar Panda ◽  
Rituparna Borah ◽  
Debasis Manna
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Binding Specificity ◽  
Binding Properties ◽  
Kinase C ◽  
P Protein ◽  
C1 Domain ◽  
Anionic Lipids

Protein kinase C-C1 domain binding specificity of the anionic hybrid lipids.

scholarly journals Characterization of the P Protein-Binding Domain on the 10-Kilodalton Protein of Borna Disease Virus

2000 ◽  
Vol 74 (7) ◽  
pp. 3413-3417 ◽  
Author(s):  
Tahir H. Malik ◽  
Masahiko Kishi ◽  
Patrick K. Lai
Keyword(s):  
Disease Virus ◽  
Nuclear Localization ◽  
Cell Nucleus ◽  
Binding Domain ◽  
Borna Disease Virus ◽  
Nuclear Localization Signals ◽  
P Protein ◽  
Infected Cells ◽  
Borna Disease

ABSTRACT The Borna disease virus (BDV) is the prototype member of the Bornaviridae, and it replicates in the cell nucleus. The BDV p24P and p40N proteins carry nuclear localization signals (NLS) and are found in the nuclei of infected cells. The BDV p10 protein does not have an NLS, but it binds with P and/or N and is translocated to the nucleus. Hence, p10 may play a role in the replication of BDV in the cell nucleus. Here, we show that the P-binding domain is located in the N terminus of p10 and that S3 and L16 are important for the interaction.

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