Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats

Amino Acids ◽  
2021 ◽  
Author(s):  
Yun Ma ◽  
Hitomi Maruta ◽  
Baojun Sun ◽  
Chengduo Wang ◽  
Chiaki Isono ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Function ◽  
Sprague Dawley ◽  
Taurine Supplementation ◽  
Skeletal Muscle Function ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
Age Related Changes

Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contractions

2011 ◽  
Vol 110 (5) ◽  
pp. 1290-1298 ◽  
Author(s):  
Daniel M. Hirai ◽  
Steven W. Copp ◽  
Peter J. Schwagerl ◽  
Timothy I. Musch ◽  
David C. Poole
Keyword(s):  
Skeletal Muscle ◽  
Hydrogen Peroxide ◽  
Muscle Function ◽  
Force Production ◽  
Sprague Dawley ◽  
Skeletal Muscle Function ◽  
Mean Response Time ◽  
Sprague Dawley Rats ◽  
Muscle Force Production ◽  
Microvascular Oxygenation

Reactive oxygen species, such as hydrogen peroxide (H2O2), exert a critical regulatory role on skeletal muscle function. Whether acute increases in H2O2 modulate muscle microvascular O2 delivery-utilization (Q̇o2/V̇o2) matching [i.e., microvascular partial pressure of O2 (PmvO2)] at rest and following the onset of contractions is unknown. The hypothesis was tested that H2O2 treatment (exogenous H2O2) would enhance PmvO2 and slow PmvO2 kinetics during contractions compared with control. Anesthetized, healthy young Sprague-Dawley rats had their spinotrapezius muscles either exposed for measurement of blood flow (and therefore Q̇o2), V̇o2, and PmvO2, or exteriorized for measurement of force production. Electrically stimulated twitch contractions (1 Hz, ∼7 V, 2-ms pulse duration, 3 min) were evoked following acute superfusion with Krebs-Henseleit (control) and H2O2 (100 μM). Relative to control, H2O2 treatment elicited disproportionate increases in Q̇o2 and V̇o2 that elevated PmvO2 at rest and throughout contractions and slowed overall PmvO2 kinetics (i.e., ∼85% slower mean response time; P < 0.05). Accordingly, H2O2 resulted in ∼33% greater overall PmvO2, as assessed by the area under the PmvO2 curve ( P < 0.05). Muscle force production was not altered with H2O2 treatment ( P > 0.05), evidencing reduced economy during contractions (∼40% decrease in the force/V̇o2 relationship; P < 0.05). These findings indicate that, although increasing the driving force for blood-myocyte O2 flux (i.e., PmvO2), transient elevations in H2O2 impair skeletal muscle function (i.e., reduced economy during contractions), which mechanistically may underlie, in part, the reduced exercise tolerance in conditions associated with oxidative stress.

scholarly journals Age-related changes in skeletal muscle function: the sum of the parts could be greater than the whole

2016 ◽  
Vol 121 (5) ◽  
pp. 1234-1234 ◽  
Author(s):  
Massimo Venturelli ◽  
Russell S. Richardson ◽  
Carlo Reggiani ◽  
Federico Schena
Keyword(s):  
Skeletal Muscle ◽  
Muscle Function ◽  
Skeletal Muscle Function ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related decline in the taurine content of the skin in rodents

Amino Acids ◽  
2021 ◽  
Author(s):  
Tomohisa Yoshimura ◽  
Yuki Inokuchi ◽  
Chikako Mutou ◽  
Takanobu Sakurai ◽  
Tohru Nagahama ◽  
...  
Keyword(s):  
High Performance ◽  
Age Groups ◽  
Immunohistochemical Analysis ◽  
Sprague Dawley ◽  
Taurine Supplementation ◽  
Hairless Mice ◽  
Age Related ◽  
Sprague Dawley Rats ◽  
High Concentrations ◽  
Effects Of Aging

AbstractTaurine, a sulfur-containing amino acid, occurs at high concentrations in the skin, and plays a role in maintaining the homeostasis of the skin. We investigated the effects of aging on the content and localization of taurine in the skin of mice and rats. Taurine was extracted from the skin samples of hairless mice and Sprague Dawley rats, and the taurine content of the skin was determined by high-performance liquid chromatography (HPLC). The results of the investigation revealed that the taurine content in both the dermis and epidermis of hairless mice declined significantly with age. Similar age-related decline in the skin taurine content was also observed in rats. In contrast, the taurine content in the sole remained unchanged with age. An immunohistochemical analysis also revealed a decreased skin taurine content in aged animals compared with younger animals, although no significant differences in the localization of taurine were observed between the two age groups. Supplementation of the drinking water of aged mice with 3% (w/v) taurine for 4 weeks increased the taurine content of the epidermis, but not the dermis. The present study showed for the first time that the taurine content of the skin decreased with age in mice and rats, which may be related to the impairment of the skin homeostasis observed with aging. The decreased taurine content of the epidermis in aged animals was able to be rescued by taurine supplementation.

scholarly journals Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. Homer-Bouthiette ◽  
L. Xiao ◽  
Marja M. Hurley
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Strength ◽  
Fibroblast Growth Factor ◽  
Muscle Function ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Skeletal Muscle Function ◽  
Age Related ◽  
Gait Disturbances

AbstractFibroblast growth factor 2 (FGF2) is important in musculoskeletal homeostasis, therefore the impact of reduction or Fgf2 knockout on skeletal muscle function and phenotype was determined. Gait analysis as well as muscle strength testing in young and old WT and Fgf2KO demonstrated age-related gait disturbances and reduction in muscle strength that were exacerbated in the KO condition. Fgf2 mRNA and protein were significantly decreased in skeletal muscle of old WT compared with young WT. Muscle fiber cross-sectional area was significantly reduced with increased fibrosis and inflammatory infiltrates in old WT and Fgf2KO vs. young WT. Inflammatory cells were further significantly increased in old Fgf2KO compared with old WT. Lipid-related genes and intramuscular fat was increased in old WT and old Fgf2KO with a further increase in fibro-adipocytes in old Fgf2KO compared with old WT. Impaired FGF signaling including Increased β-Klotho, Fgf21 mRNA, FGF21 protein, phosphorylated FGF receptors 1 and 3, was observed in old WT and old Fgf2KO. MAPK/ ERK1/2 was significantly increased in young and old Fgf2KO. We conclude that Fgf2KO, age-related decreased FGF2 in WT mice, and increased FGF21 in the setting of impaired Fgf2 expression likely contribute to impaired skeletal muscle function and sarcopenia in mice.

The Effects of Aging and Training on Skeletal Muscle

1998 ◽  
Vol 26 (4) ◽  
pp. 598-602 ◽  
Author(s):  
Donald T. Kirkendall ◽  
William E. Garrett
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Function ◽  
Cellular Level ◽  
Type I ◽  
Loss Of Function ◽  
Skeletal Muscle Function ◽  
Cross Sectional ◽  
Age Related ◽  
General Slowing

Aging results in a gradual loss of muscle function, and there are predictable age-related alterations in skeletal muscle function. The typical adult will lose muscle mass with age; the loss varies according to sex and the level of muscle activity. At the cellular level, muscles loose both cross-sectional area and fiber numbers, with type II muscle fibers being the most affected by aging. Some denervation of fibers may occur. The combination of these factors leads to an increased percentage of type I fibers in older adults. Metabolically, the glycolytic enzymes seem to be little affected by aging, but the aerobic enzymes appear to decline with age. Aged skeletal muscle produces less force and there is a general “slowing” of the mechanical characteristics of muscle. However, neither reduced muscle demand nor the subsequent loss of function is inevitable with aging. These losses can be minimized or even reversed with training. Endurance training can improve the aerobic capacity of muscle, and resistance training can improve central nervous system recruitment of muscle and increase muscle mass. Therefore, physical activity throughout life is encouraged to prevent much of the age-related impact on skeletal muscle.

scholarly journals Long Term Capsaicin Administration Effects on Skeletal Muscle Function in Aging Mice

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Marisa Benson ◽  
Candace Receno ◽  
Angela Le ◽  
Sarah Ruby ◽  
Chen Liang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Function ◽  
Skeletal Muscle Function
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