The relationship between alcohol intake and cellular immune activity in systemic lupus erythematosus may change from inhibitory to stimulatory within 2 months of study: findings from an integrative single-case study

2009 ◽  
Vol 29 (2) ◽  
pp. 229-230 ◽  
Author(s):  
Christian Schubert ◽  
Dietmar Fuchs
Pteridines ◽  
2009 ◽  
Vol 20 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Christian Schubert ◽  
Astrid Lampe ◽  
Willi Geser ◽  
Mathias Merk ◽  
Marcel Jenny ◽  
...  

Abstract In recent years, interest has been growing regarding the role of alcohol intake on systemic lupus erythematosus (SLE) disease activity. This integrative single-case study investigated the dynamic interdependencies between alcohol consumption, various emotional states and cellular immune activity in SLE using time series analysis (i.e., ARIMA modeling, cross-correlational analysis). We determined neopterin concentrations (HPLC) in a 52-year-old woman suffering from SLE, who collected her entire urine on a twice-daily basis for a period of 56 days (total: 112 time-points). Aside from the central interest of our studies, i.e., the impact of everyday incidents on cellular immune system dynamics, the patient also provided daily information on intake of alcoholic beverages (type and quantity) and various emotional state variables (mental activity, irritation, mood). Cross-correlational analyses revealed that moderate alcohol consumption had different effects on urinary neopterin levels depending on whether time series data were analyzed before or after the occurrence of an inflammatory event (acute paranasal sinusitis) that had taken place halfway through the study period (time-points 45-54). Before sinusitis (1-44), increases in alcohol consumption were parallelized by decreases in urinary neopterin levels (lag0: r = -0.371; p< 0.05) whereas after sinusitis (55-112), increases in alcohol intake preceded increases in urinary neopterin levels with a temporal delay of 12 hours (lag1: r = +0.308; p< 0.05). The emotional states under study did not interfere with the associations between alcohol intake and neopterin levels. These findings show that even within the same patient with SLE the relationship between alcohol intake and neopterin levels might not always be stable suggesting a possible reason for inconsistent evidence from cross-correlational studies.


2018 ◽  
Vol 14 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Zhaleh Shariati Sarabi ◽  
Maryam Sahebari ◽  
Ali Etemad Rezaie ◽  
Mohammad Taghi Norouzi ◽  
Kamila Hashemzadeh ◽  
...  

Lupus ◽  
2020 ◽  
Vol 29 (2) ◽  
pp. 182-190
Author(s):  
W Batista Cicarini ◽  
R C Figueiredo Duarte ◽  
K Silvestre Ferreira ◽  
C de Mello Gomes Loures ◽  
R Vargas Consoli ◽  
...  

We have explored the relationship between possible hemostatic changes and clinical manifestation of the systemic lupus erythematosus (SLE) as a function of greater or lesser disease activity according to Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2K) criteria. Endothelial injury and hypercoagulability were investigated in patients with SLE by measuring thrombomodulin (TM), D-dimer (DDi) and thrombin generation (TG) potential. A total of 90 participants were distributed into three groups: 1) women with SLE presenting with low disease activity (laSLE) (SLEDAI-2K ≤ 4), 2) women with SLE presenting with moderate to high disease activity (mhaSLE) (SLEDAI-2K > 4), and 3) a control group comprising healthy women. Levels of TM and DDi were higher both in the laSLE and mhaSLE groups compared to controls and in mhaSLE compared to the laSLE group. With respect to TG assay, lagtime and endogen thrombin potential, low concentrations of tissue factor provided the best results for discrimination among groups. Analysis of these data allow us to conclude that TM, DDi and TG are potentially useful markers for discriminating patients with very active from those with lower active disease. Higher SLE activity may cause endothelial injury, resulting in higher TG and consequently a hypercoagulability state underlying the picture of thrombosis common in this inflammatory disease.


Author(s):  
Francesca Locati ◽  
Pietro De Carli ◽  
Emanuele Tarasconi ◽  
Margherita Lang ◽  
Laura Parolin

The relationship between transference and therapeutic alliance has been long discussed. It is only recently, however, that empirical evidence has provided support for a tight correspondence between several transference dimensions and rupture and resolution processes. In the present single-case study, we used alliance ruptures as a key dimension to understand patient’s transference dynamics. This was achieved in a particular form of patient’s behavior, i.e., patient’s deference and acquiescent behavior, which describes a significant submission to assertions, skills, judgments and point of views of another person. Therapeutic process was measured by means of the Rupture Resolution Rating Scale, the Core Conflictual Relationship Theme and the Defense Mechanism Rating Scales, whereas therapeutic outcome was measured by means of the Shedler-Westen Assessment Procedure-200. Results of sequential analysis yielded a significant correspondence between rupture markers, characterized by avoidance and shifting of session’s topic, and patient’s narrations. Furthermore, a systematic correspondence between alliance ruptures and patient’s avoidant functioning, which emerged both in transference relationship and in the quality of the defense structure, was found. Together, these findings indicate that patient’s deference inhibits the expression of relational themes, with ruptures in alliance that seem to be supported by a strong defensive structure. In particular, patient’s avoidance played a double role in the treatment. On the one hand, avoidance was the main characteristic of her transference structure, based on extreme intellectualization and emotional closure. On the other hand, it contributed to create an impasse in the treatment, based on a withdrawal ruptures model and on obsessive level defences.


2017 ◽  
Vol 130 (11) ◽  
pp. 1290-1297.e6 ◽  
Author(s):  
Ashley E. Wivel ◽  
Kate Lapane ◽  
Christi Kleoudis ◽  
Burton H. Singer ◽  
Ralph I. Horwitz

1997 ◽  
Vol 3 (4) ◽  
pp. 377-386 ◽  
Author(s):  
SUSAN D. DENBURG ◽  
RAMONA M. CARBOTTE ◽  
JEFFREY S. GINSBERG ◽  
JUDAH A. DENBURG

Objective: To examine the relationship between antiphospholipid antibody positivity (expressed as the lupus anticoagulant) and cognitive dysfunction in patients with systemic lupus erythematosus (SLE). Methods: Cross-sectional comparisons of lupus anticoagulant (LA) positive (N = 39) and negative (N = 79) patients and controls (N = 35) on a cognitive test battery; 22 LA-positive and 53 LA-negative patients who had never experienced neuropsychiatric events (never-NP–SLE) were also compared separately. Results: LA-positive patients were 2 to 3 times more likely than were LA-negative patients to be designated as cognitively impaired. As a group, LA-positive patients, particularly those in the never-NP–SLE group, demonstrated lower performance primarily on tasks of verbal memory, cognitive flexibility, and psychomotor speed. Conclusions: LA positivity is associated with subclinical nervous system compromise, and a pattern of deficits compatible with subcortical involvement, possibly on the basis of ongoing LA-related microthrombotic events or vasculopathy. (JINS, 1997, 3, 377–386.)


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