Omega-3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-α), disease activity and response criteria

2011 ◽  
Vol 31 (2) ◽  
pp. 363-366 ◽  
Author(s):  
Tamer Gheita ◽  
Sahar Kamel ◽  
Neveen Helmy ◽  
Nabila El-Laithy ◽  
Amira Monir
Keyword(s):  
Fatty Acids ◽  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Response Criteria ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Tnf Α

scholarly journals SAT0110 HIGH SERUM LONG-CHAIN OMEGA-3 FATTY ACIDS ARE ASSOCIATED WITH 6-MONTHLOWER DISEASE ACTIVITY IN EARLY RA: RESULTS FROM THE ESPOIR COHORT

2019 ◽  
Author(s):  
Johanna Sigaux ◽  
Camille de Brauer Buscail ◽  
Chantal Julia ◽  
Rene Marc Flipo ◽  
Alain Cantagrel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Disease Activity ◽  
High Serum ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Early Ra ◽  
Long Chain

scholarly journals The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial

2015 ◽  
Vol 8 (7) ◽  
pp. 18 ◽  
Author(s):  
Elham Rajaei ◽  
Karim Mowla ◽  
Ali Ghorbani ◽  
Sara Bahadoram ◽  
Mohammad Bahadoram ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Disease Activity ◽  
Active Rheumatoid Arthritis ◽  
Controlled Study ◽  
Unknown Etiology ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Weight Changes ◽  
Double Blind

<p><strong>BACKGROUND:</strong> Rheumatoid arthritis is a symmetric peripheral polyarthritis of unknown etiology that, untreated or if unresponsive the therapy, typically leads to deformity and destruction of joints due to erosion of cartilage and bone. Omega-3 fatty acids have been shown to reduce morning stiffness, the number of tender joints and swollen joints in patients with rheumatoid arthritis. This study is designed for evaluation of omega-3 effects on disease activity and remission of rheumatoid arthritis in DMARDs treated patients and on weight changes and reduction of analgesic drugs consumption versus placebo.</p><p><strong>METHODS:</strong> Sixty patients with active rheumatoid arthritis (49 female and 11 male) underwent rheumatologist examination and disease activity score were calculated. Then patients were enrolled in this 12 week, double blind, randomized, placebo- controlled study. The patients in both groups continued their pre study standard treatment. The patients were visited every 4 weeks, 4 times and data were recorded.</p><p><strong>RESULTS:</strong> Significant improvement in the patient's global evaluation and in the physician's assessment of disease was observed in those taking omega-3. The proportions of patients who improved and of those who were able to reduce their concomitant analgesic medication were significantly greater with omega-3 consumption. There were no weight changes.</p><p><strong>CONCLUSION:</strong> Daily supplementation with omega-3 results has significant clinical benefit and may reduce the need for concomitant analgesic consumption without weight changes.</p>

scholarly journals Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells

2020 ◽  
Author(s):  
Aysan Eslami Abriz ◽  
Reza Rahbarghazi ◽  
Alireza Nourazarian ◽  
Çıgır Biray Avci ◽  
Soltan Ali Mahboob ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Docosahexaenoic Acid ◽  
Palmitic Acid ◽  
Pcr Array ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Human Endothelial Cells ◽  
Array Analysis ◽  
Tnf Α

Abstract Background: Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA), has been investigated in cells after exposure to high doses of lipids. The current experiment aimed to address the modulatory effects of docosahexaenoic acid and insulin in palmitic-treated human endothelial cells. Methods: Human umbilical vein endothelial cells were treated with 1mM palmitic acid, 50μM insulin, 50μM docosahexaenoic acid, and their combination for 48 hours. Cell survival rate and apoptosis were measured using MTT and flow cytometry assays. The Griess assay detected NO levels. Protein levels of TNF-α, IL-6, and NF-κB were studied using ELISA and immunofluorescence imaging. The expression of genes participating in atherosclerosis was monitored using PCR array analysis. Results: Oil Red O staining showed the inhibitory effect of DHA and insulin to reduce the intracellular accumulation of palmitic acid. Both DHA and Insulin blunted palmitic acid detrimental effects on HUVECs indicated by an increased survival rate (p<0.05). The percent of apoptotic cells was decreased in palmitic-treated cells received insulin and DHA compared to palmitic-treated group (p<0.05). Based on our data, DHA and Insulin diminished the production of all inflammatory cytokines, TNF-α, IL-6, and NF-κB, in palmitic-treated cells (p<0.05). Similar to these data, NO production was also decreased in all groups treated with insulin and DHA compared to the palmitic-treated cells (p<0.05). PCR array analysis revealed the modulatory effect of DHA and insulin on the expression of atherosclerosis-related genes pre-treated with palmitic acid compared to the control group (p<0.05). Conclusion: DHA and Insulin could alter the dynamic growth and dysfunctional activity of human endothelial cells after treatment with palmitic acid. Taken together, Omega 3 fatty acids, along with insulin, could dictate specific cell behavior in endothelial cells in vitro

Omega 3 Fatty Acids Counteract IL-8 and Prostaglandin E2 Secretion Induced by TNF-α in Cultured Endometrial Stromal Cells

2011 ◽  
Vol 3 (1) ◽  
pp. 34-39
Author(s):  
Romina Novembri ◽  
Stefano Luisi ◽  
Patrizia Carrarelli ◽  
Valentina Ciani ◽  
Flavio de Pascalis ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Inflammatory Mediators ◽  
Stromal Cells ◽  
Inhibitory Effect ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Endometrial Stromal Cells ◽  
Tnf Α ◽  
Key Enzyme ◽  
Cox 2

Background Inflammation is part of the normal host response to infection and injury and excess inflammation may lead to acute or chronic diseases. Endometriosis is a common gynecologic disease characterized by increased endometrial production of inflammatory mediators such as cytokines, reactive oxygen species, and prostaglandins. Omega-3 polyunsaturated fatty acids play a role in the inflammatory process and a therapeutic effect has been suggested. Methods On this basis, this study aimed to assess in human cultured endometrial stromal cells the effect of two omega-3 fatty acids (DHA and EPA), on i) TNF-α induced IL-8 and PGE2 release and on ii) cyclooxygenase-2 (Cox-2) mRNA expression a key enzyme for prostaglandin production. Results DHA or EPA significantly reduced LPS-induced IL-8 (P<0.01) and PGE2 (P<0.01) release decreasing the expression of Cox-2 (P<0.01). Conclusions In conclusion, our study revealed an inhibitory effect of omega-3 fatty acids on inflammatory mediators secretion and suggests a potential benefit for the treatment of pelvic pain in patients with dysmenorrhea and/or endometriosis.

scholarly journals Role of omega-3 fatty acid supplementation with indomethacin in suppression of disease activity in rheumatoid arthritis

2009 ◽  
Vol 35 (2) ◽  
pp. 63-68 ◽  
Author(s):  
Ashoke Bijoy Das Gupta ◽  
A.K.M. Mosharrof Hossain ◽  
Md. Hilalul Islam ◽  
Sudhangshu Ranjan Dey ◽  
Md. Abdul Latif Khan
Keyword(s):  
Rheumatoid Arthritis ◽  
Fatty Acids ◽  
Disease Activity ◽  
Morning Stiffness ◽  
Treated Group ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Omega 3 Fatty Acid

 A study was conducted to see the diseases activity suppression role of omega-3 fatty acids with indomethacin in patients with rheumatoid arthritis. One group received indomethacin (75 mg) only daily while another group received indomethacin (75 mg) along with omega-3 fatty acids (3 g) daily for 12 weeks. The main outcome measures were DAS 2-28 joints score, number of swollen joints, number of tender joints, duration of morning stiffness, grip strength, pain VAS, patients global VAS, erythrocyte sedimentation rate and C-reactive protein. In terms of outcome both the groups experienced a modest improvement in disease activity after 12 weeks of treatment. However, compared to indomethacin–treated group, omega-3 plus indomethacin–treated group achieved a better improvement in terms of reducing disease activity. Physical functioning, physical role, bodily pain, general health, vitality, social functioning, grip strength, duration of morning stiffness improved significantly better in the combination group compared to indomethacin only group. The safety measures included liver and kidney function tests done didn’t differ between the study groups. This study suggests that omega-3 fatty acid supplementation with indomethacin might ameliorate disease activity and be non-steroidal anti-inflammatory drugs (NSAIDs) sparing in rheumatoid arthritis.Keywords: Rheumatoid arthritis; Indomethacin; Omega-3 fatty acidOnline: 25 August 2009DOI: 10.3329/bmrcb.v35i2.3020Bangladesh Med Res Counc Bull 2009; 35: 63-68  

Effect of omega-3 fatty acids on systemic lupus erythematosus disease activity: A systematic review and meta-analysis

2020 ◽  
Vol 19 (12) ◽  
pp. 102688
Author(s):  
Alí Duarte-García ◽  
Elena Myasoedova ◽  
Paras Karmacharya ◽  
Mehmet Hocaoğlu ◽  
M. Hassan Murad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systemic Lupus Erythematosus ◽  
Fatty Acids ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Systemic Lupus Erythematosus Disease ◽  
Systemic Lupus

scholarly journals Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Aysan Eslami Abriz ◽  
Reza Rahbarghazi ◽  
Alireza Nourazarian ◽  
Çıgır Biray Avci ◽  
Soltan Ali Mahboob ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Docosahexaenoic Acid ◽  
Palmitic Acid ◽  
Pcr Array ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Human Endothelial Cells ◽  
Array Analysis ◽  
Tnf Α

Abstract Background Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA), has been investigated in cells after exposure to high doses of lipids. The current experiment aimed to address the modulatory effects of docosahexaenoic acid and insulin in palmitic-treated human endothelial cells. Methods Human umbilical vein endothelial cells were treated with 1 mM palmitic acid, 50 μM insulin, 50 μM docosahexaenoic acid, and their combination for 48 h. Cell survival rate and apoptosis were measured using MTT and flow cytometry assays. The Griess assay detected NO levels. Protein levels of TNF-α, IL-6, and NF-κB were studied using ELISA and immunofluorescence imaging. The expression of genes participating in atherosclerosis was monitored using PCR array analysis. Results Oil Red O staining showed the inhibitory effect of DHA and insulin to reduce the intracellular accumulation of palmitic acid. Both DHA and Insulin blunted palmitic acid detrimental effects on HUVECs indicated by an increased survival rate (p < 0.05). The percent of apoptotic cells was decreased in palmitic-treated cells received insulin and DHA compared to palmitic-treated group (p < 0.05). Based on our data, DHA and Insulin diminished the production of all inflammatory cytokines, TNF-α, IL-6, and NF-κB, in palmitic-treated cells (p < 0.05). Similar to these data, NO production was also decreased in all groups treated with insulin and DHA compared to the palmitic-treated cells (p < 0.05). PCR array analysis revealed the modulatory effect of DHA and insulin on the expression of atherosclerosis-related genes pre-treated with palmitic acid compared to the control group (p < 0.05). Conclusion DHA and Insulin could alter the dynamic growth and dysfunctional activity of human endothelial cells after treatment with palmitic acid. Taken together, Omega 3 fatty acids, along with insulin, could dictate specific cell behavior in endothelial cells in vitro.

Plasma Phospholipid Fatty Acid Content Is Related to Disease Activity in Ankylosing Spondylitis

2011 ◽  
Vol 39 (2) ◽  
pp. 327-333 ◽  
Author(s):  
BJÖRN SUNDSTRÖM ◽  
GUNNAR JOHANSSON ◽  
HEIDI KOKKONEN ◽  
TOMMY CEDERHOLM ◽  
SOLVEIG WÅLLBERG-JONSSON
Keyword(s):  
Fatty Acids ◽  
Arachidonic Acid ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Blood Lipids ◽  
Plasma Phospholipid ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Plasma Phospholipids ◽  
Long Chain

Objective.To investigate fatty acid composition in the diet, plasma phospholipids, and adipose tissue in a cohort of patients with ankylosing spondylitis (AS), and to determine their correlations to disease activity and blood lipids in a cross-sectional study.Methods.Diet was assessed using a food frequency questionnaire in 66 patients with AS. Polyunsaturated fatty acids in plasma phospholipids and gluteal adipose tissue were measured using gas chromatography. Disease status was quantified using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein, and proinflammatory cytokines.Results.Diet did not correlate with disease activity assessed by the BASDAI, but there were negative correlations between the dietary intake of long-chain omega-3 fatty acids and ESR (rs = –0.27, p < 0.05). The plasma phospholipid content of arachidonic acid correlated significantly with the BASDAI score (rs = 0.39, p < 0.01). There were correlations between the intake of long-chain omega-3 fatty acids and high-density lipoproteins and serum triglycerides (rs = 0.26 and rs = –0.25, respectively, p < 0.05).Conclusion.There was a positive correlation between levels of arachidonic acid in plasma phospholipids and disease activity assessed by BASDAI in patients with AS. A Western diet does not appear to influence this correlation, but seems to affect blood lipids involved in atherogenic processes.

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