Elevated serum levels of soluble CD146 in patients with systemic sclerosis

2016 ◽  
Vol 36 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Tomoko Ito ◽  
Naoto Tamura ◽  
Sayuri Okuda ◽  
Kurisu Tada ◽  
Masakazu Matsushita ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Elevated Serum ◽  
Serum Levels ◽  
Soluble Cd146

scholarly journals Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis

2009 ◽  
pp. 168-176 ◽  
Author(s):  
Akira Tokumura ◽  
Laura D. Carbone ◽  
Yasuko Yoshioka ◽  
Junichi Morishige ◽  
Masaki Kikuchi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Lysophosphatidic Acid ◽  
Elevated Serum ◽  
Serum Levels ◽  
Sphingosine 1 Phosphate

Elevated serum levels of interleukin-1β and interleukin-33 in patients with systemic sclerosis in Chinese population

2016 ◽  
Vol 77 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Y.-J. Zhang ◽  
Q. Zhang ◽  
G.-J. Yang ◽  
J.-H. Tao ◽  
G.-C. Wu ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Chinese Population ◽  
Elevated Serum ◽  
Serum Levels ◽  
Interleukin 1Β ◽  
Interleukin 33

Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis

2009 ◽  
Vol 36 (1) ◽  
pp. 99-105 ◽  
Author(s):  
TOSHIHIDE HARA ◽  
FUMIHIDE OGAWA ◽  
KOICHI YANABA ◽  
YOHEI IWATA ◽  
EIJI MUROI ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Pulmonary Fibrosis ◽  
Elevated Serum ◽  
Serum Levels ◽  
Oxidative Stress Marker ◽  
Surfactant Protein D ◽  
Serum Concentrations ◽  
Leukocyte Elastase ◽  
Pmn Elastase ◽  
Pmn Élastase

ObjectiveTo determine the serum concentrations and clinical association of polymorphonuclear neutrophilic leukocyte (PMN) elastase in patients with systemic sclerosis (SSc).MethodsSerum PMN elastase levels from 21 patients with limited cutaneous SSc (lSSc) and 32 with diffuse cutaneous SSc (dSSc) were examined by ELISA.ResultsSerum PMN elastase levels were elevated in patients with SSc, especially dSSc, compared to healthy controls. SSc patients with elevated serum PMN elastase levels had more frequent presence of pulmonary fibrosis, arthritis, contracture of phalanges, and diffuse pigmentation. Anticentromere antibody was detected less frequently in SSc patients with elevated serum PMN elastase levels than in controls. Consistently, serum PMN elastase levels also correlated positively with serum levels of KL-6 and surfactant protein-D, serological markers for pulmonary fibrosis. Serum PMN elastase levels were also associated with levels of serum 8-isoprostane, an oxidative stress marker in SSc.ConclusionSerum PMN elastase levels were elevated in patients with SSc, and it was more prominent in patients with pulmonary fibrosis, suggesting that serum PMN elastase is a novel serological marker for SSc-related pulmonary fibrosis.

scholarly journals Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis

2019 ◽  
Vol 312 (6) ◽  
pp. 453-458
Author(s):  
Anna Stochmal ◽  
Joanna Czuwara ◽  
Michał Zaremba ◽  
Lidia Rudnicka
Keyword(s):  
Adipose Tissue ◽  
Systemic Sclerosis ◽  
Serum Level ◽  
Elevated Serum ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Vascular Abnormalities ◽  
Endothelin 1 ◽  
Fibrotic Process ◽  
Galectin 3

Abstract Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by progressive fibrosis, vascular impairment and immune abnormalities. In recent years, adipokines (mediators synthetized by adipose tissue) have been indicated as a possible missing link in the pathogenesis of SSc. The aim of this study was to investigate the serum concentration of metabolic adipose tissue factors: adiponectin, resistin, leptin and endothelial proteins: endothelin-1, fractalkine and galectin-3 in patients with systemic sclerosis. The study included 100 patients with confirmed SSc diagnosis and 20 healthy individuals. The concentration of respective proteins was determined by enzyme-linked immunosorbent assay. The following markers showed statistically significant increased mean concentrations in patients with SSc in comparison to healthy control: resistin (13.41 vs 8.54 ng/mL; P = 0.0012), endothelin-1 (1.99 vs 1.31 pg/mL; P = 0.0072) and fractalkine (2.93 vs 1.68 ng/mL; P = 0.0007). Elevated serum levels of galectin-3 (4.54 vs 3.26 ng/mL; P = 0.0672) and leptin (19,542 vs 14,210 pg/mL; P = 0.1817) were observed. Decreased concentration of adiponectin was found in patients with SSc (5150 vs 8847 pg/mL; P = 0.0001). Fractalkine and galectin-3 levels were significantly higher in diffuse cutaneous SSc than limited cutaneous SSc subset (3.93 ng/mL vs 2.58 ng/mL, P = 0.0018; 6.86 ng/mL vs 3.78 ng/mL, P = 0.0008, respectively) and correlated positively with modified Rodnan Skin Score in total SSc patients (r = 0.376, P = 0.0009; r = 0.236, P = 0.018, respectively). In conclusion, an increased serum level of resistin associated with increased endothelin-1 and fractalkine level and decreased adiponectin level may indicate a significant role of the adipose tissue in the development and progression of vascular abnormalities in patients with systemic sclerosis. Fractalkine and galectin-3 may participate in promoting and exacerbating the fibrotic process in SSc.

Elevated serum levels of sonic hedgehog are associated with fibrotic and vascular manifestations in systemic sclerosis

2017 ◽  
Vol 77 (4) ◽  
pp. 626-628 ◽  
Author(s):  
Christian Beyer ◽  
Dörte Huscher ◽  
Andreas Ramming ◽  
Christina Bergmann ◽  
Jerome Avouac ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Sonic Hedgehog ◽  
Elevated Serum ◽  
Serum Levels

Elevated serum levels of a proliferation-inducing ligand in patients with systemic sclerosis: Possible association with myositis?

2011 ◽  
Vol 78 (1) ◽  
pp. 56-61 ◽  
Author(s):  
Iman H. Bassyouni ◽  
Noha A. Azab ◽  
El-Hussein M. El-Dakrony ◽  
Marwa M.T. Fawzi ◽  
Randa Ghanoum ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Elevated Serum ◽  
Serum Levels

Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis

2009 ◽  
Vol 36 (5) ◽  
pp. 976-983 ◽  
Author(s):  
YOHEI IWATA ◽  
AYUMI YOSHIZAKI ◽  
FUMIHIDE OGAWA ◽  
KAZUHIRO KOMURA ◽  
TOSHIHIDE HARA ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Normal Skin ◽  
Elevated Serum ◽  
Serum Levels ◽  
Skin Thickness ◽  
Pentraxin 3 ◽  
Clinical Associations ◽  
Immunoglobulin Levels ◽  
Erythrocyte Sedimentation Rates ◽  
Frequent Presence

Objective.To determine serum concentrations of pentraxin 3 (PTX3) and its clinical associations in patients with systemic sclerosis (SSc).Methods.Serum PTX3 levels from 45 patients with diffuse cutaneous SSc (dSSc), 46 with limited cutaneous SSc (lSSc), and 20 healthy controls were examined by ELISA. PTX3 expression in the sclerotic skin from SSc patients was evaluated immunohistochemically. Normal and SSc fibroblasts were cultured and PTX3 levels in the culture medium were also examined by ELISA.Results.Serum PTX3 levels were elevated in patients with SSc relative to controls. PTX3 levels in dSSc patients were significantly higher than in controls and lSSc patients. PTX3 expression in the sclerotic skin from SSc patients was more intense relative to normal skin. Elevation of serum PTX3 levels was associated with more frequent presence of pulmonary fibrosis, cardiac disease, and pitting scar/ulcer and increased serum immunoglobulin levels and erythrocyte sedimentation rates. PTX3 levels correlated positively with modified Rodnan total skin thickness score, and negatively with percentage vital capacity and percentage DLCO in patients with SSc. PTX3 levels also correlated positively with serum levels of 8-isoprostane, a marker of oxidative stress, and hyaluronan, recently identified as an endogenous ligand for Toll-like receptors. PTX3 production from cultured SSc fibroblasts was increased by stimulation with hyaluronan.ConclusionThese results suggest that elevated serum PTX3 levels are associated with the disease severity of SSc.

scholarly journals Reassessing the Role of the Active TGF-β1 as a Biomarker in Systemic Sclerosis: Association of Serum Levels with Clinical Manifestations

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Andréa Tavares Dantas ◽  
Sayonara Maria Calado Gonçalves ◽  
Anderson Rodrigues de Almeida ◽  
Rafaela Silva Guimarães Gonçalves ◽  
Maria Clara Pinheiro Duarte Sampaio ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Clinical Manifestations ◽  
Serum Levels ◽  
Vascular Involvement ◽  
Digital Ulcers ◽  
Serum Samples ◽  
Peripheral Blood Mononuclear ◽  
Pbmc Culture ◽  
Significant Difference ◽  
Skin Biopsies

Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients.Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (HC). In 20 SSc patients, we quantified spontaneous or anti-CD3/CD28 stimulated production of aTGF-β1 by PBMC. The aTGF-β1 levels were measured by ELISA. Skin biopsies were obtained from 13 SSc patients and six HC, and TGFB1 expression was analyzed by RT-PCR.Results. TGF-β1 serum levels were significantly higher in SSc patients than in HC (p< 0.0001). Patients with increased TGF-β1 serum levels were more likely to have diffuse subset (p= 0.02), digital ulcers (p= 0.02), lung fibrosis (p< 0.0001), positive antitopoisomerase I (p= 0.03), and higher modified Rodnan score (p= 0.046). Most of our culture supernatant samples had undetectable levels of TGF-β1. No significant difference in TGFB1 expression was observed in the SSc skin compared with HC skin.Conclusion. Raised active TGF-β1 serum levels and their association with clinical manifestations in scleroderma patients suggest that this cytokine could be a marker of fibrotic and vascular involvement in SSc.

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