Rheumatoid arthritis and neurodegenerative dementia: a nested case-control study and a follow-up study using a national sample cohort

ObjectivesThis study investigated the risk of neurodegenerative dementia following asthma.DesignA nested case–control studySettingThe ≥60-year-old population was selected from the Korean Health Insurance Review and Assessment Service – National Sample Cohort from 2002 to 2013.Participants and interventionsThe 11 442 dementia cases were matched with 45 768 control cases for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Asthma was classified using International Classification of Disease-10 (ICD-10) codes (J45 and J46) and medication history. Dementia was identified based on ICD-10 codes (G30 and F00).Primary and secondary outcome measuresThe ORs of a previous history of asthma in patients with dementia were analysed using conditional logistic regression analysis stratified for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Subgroup analysis was performed according to age and sex.ResultsOverall, 22.6% (2587/11 442) and 22.3% (10 229/45 768) of the cases in the dementia and control groups, respectively, had a previous history of asthma. The OR for asthma in the dementia group was not higher than that in the control group (adjusted OR=0.97, 95% CI 0.92 to 1.02, p=0.207). All age and sex subgroups demonstrated consistent results.ConclusionsAsthma was not related to an increased risk of dementia.

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Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study

American Journal of Alzheimer s Disease & Other Dementias® ◽

10.1177/15333175211006504 ◽

2021 ◽

Vol 36 ◽

pp. 153331752110065

Author(s):

Hyo Geun Choi ◽

Bum Jung Park ◽

Jae Sung Lim ◽

Song Yong Sim ◽

Yoon Jung Jung ◽

...

Keyword(s):

Herpes Zoster ◽

Case Control Study ◽

Matched Control ◽

National Sample ◽

Case Control ◽

Herpes Zoster Infection ◽

Neurodegenerative Dementia ◽

National Cohort ◽

Korean National Health Insurance ◽

Control Study

Objective: This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort. Methods: From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI. Results: The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women. Conclusions: We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

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Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case–control study using a national sample cohort

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-018-5230-y ◽

2018 ◽

Vol 276 (2) ◽

pp. 335-342 ◽

Cited By ~ 9

Author(s):

Hyo Geun Choi ◽

Joon Kyu Lee ◽

Il Gyu Kong ◽

Hyun Lim ◽

So Young Kim

Keyword(s):

Benign Paroxysmal Positional Vertigo ◽

Case Control Study ◽

National Sample ◽

Case Control ◽

Positional Vertigo ◽

Nested Case Control ◽

Control Study ◽

Paroxysmal Positional Vertigo

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Efficacy of Vitamin E in Methotrexate-Induced Hepatotoxicity in Rheumatoid Arthritis: An Open-Label Case-Control Study

International Journal of Rheumatology ◽

10.1155/2020/5723485 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Binit Vaidya ◽

Manisha Bhochhibhoya ◽

Shweta Nakarmi

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin E ◽

Treatment Group ◽

Case Control Study ◽

Study Groups ◽

Case Control ◽

Control Group ◽

Open Label ◽

Control Study

Objective. To examine the efficacy of vitamin E in methotrexate- (MTX-) induced transaminitis in patients with rheumatoid arthritis (RA). Methods. A case-control study was conducted at a tertiary rheumatology center for 12 months. Patients with RA on MTX and deranged aminotransferases were included. Patients with previous liver diseases, baseline transaminitis before methotrexate initiation, alcohol intake, muscle diseases, under hepatotoxic drugs, and aminotransferases>3 times the upper normal limit were excluded. The patients were divided into treatment (vitamin E 400 mg bid for 3 months) and control groups (no vitamin E) using a random number table. The dose of MTX was unaltered. Follow-up was done after 3 and 6 months. Independent t-test was done to compare means of two groups. Paired t-test was done to compare differences in mean. Results. Among 230 patients, 86.5% were female with a mean BMI of 25.9±4.5 kg/m2. In the treatment group, SGPT and SGOT at baseline were 73.1±20.4 and 60.2±24.5 IU/L, respectively; at 3-month follow-up 44.6±34.2 and 38.3±20.8 IU/L, respectively; and at 6-month follow-up 40.4±35.7 and 34.2±21.9 IU/L, respectively. In the control group, SGPT and SGOT at baseline were 63.4±15.1 and 46.8±13.7 IU/L, respectively, and at 3-month follow-up 55.8±45.9 and 45.5±30.9 IU/L, respectively. Significant decrease in the level of aminotransferases was seen in the treatment group (p value < 0.001) and not in the control group (p values 0.161 and 0.728, respectively). The change in levels of SGPT and SGOT from baseline to 3 months of follow-up was statistically significant in between two study groups (p values 0.007 and <0.001, respectively). From the control group, 29 patients were crossed over to vitamin E for the next 3 months. SGPT and SGOT decreased from 97.6±44.1 to 46.1±40.9 and 69.3±34.9 to 29.1±11.6 IU/L, respectively (p values 0.031 and 0.017, respectively). Conclusion. Vitamin E significantly attenuates MTX-induced transaminitis.

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