Influence of glutathione S transferase A1 gene polymorphism (-69C > T, rs3957356) on intravenous cyclophosphamide efficacy and side effects: a case-control study in Egyptian patients with lupus nephritis

Author(s):  
Doaa H. S. Attia ◽  
Mervat Eissa ◽  
Lamees A. Samy ◽  
Rasha A. Khattab
2020 ◽  
Vol 65 (1) ◽  
pp. 65
Author(s):  
Ola Bakry ◽  
Alaa Mariee ◽  
Iman Badr ◽  
Nermin Tayel ◽  
Samar El Gendy

2019 ◽  
Vol 87 (12) ◽  
pp. 4165-4173
Author(s):  
DOAA M.A. ELZOGHBY, M.D.; MONA M. OSMAN, M.D. ◽  
RANDA M. AMIN, M.D.; HEBA H. ALY, M.D. ◽  
NEHAL E. MAHMOUD, M.D.; DALIA M. ELFAWY, M.D. ◽  
SOMIA ABDELHAMID BAWADY, M.Sc.

2011 ◽  
Vol 7 (2-4) ◽  
pp. 199-203 ◽  
Author(s):  
Farah Lotfi Kashani ◽  
Dor Mohammad Kordi-Tamandani ◽  
Roya Sahranavard ◽  
Mohammad Hashemi ◽  
Farzaneh Kordi-Tamandani ◽  
...  

Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene–gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 & GSTM1 genotypes (OR = 2.51; 95% CI: 1.13–5.63, P = 0.02). The AG and combined AG + GG genotypes of GSTP1 increased the risk of SCZ (OR = 1.83; 95% CI: 0.94–3.75 and OR = 1.71; 95% CI: 0.92–3.19, respectively). The genotypes of GSTT/NULL, NULL/GSTM and NULL/NULL increased the risk of SCZ (OR = 2.05; 95% CI: 0.9–4.74; OR = 2.0; 95% CI: 1.68–2.31; and OR = 1.8; 95% CI: 0.57–2.46, respectively). The present study supports previous data that suggest that impairment in the function of GSTs genes may increase the risk of SCZ.


2017 ◽  
Vol Volume 11 ◽  
pp. 549-555 ◽  
Author(s):  
Najwa Al-Dabbagh ◽  
Hamoud Al-Shahrani ◽  
Nourah Al-Dohayan ◽  
Md Mustafa ◽  
Misbahul Arfin ◽  
...  

2017 ◽  
Vol 52 (12) ◽  
pp. 1592-1598 ◽  
Author(s):  
Heba Abouzeid ◽  
Usama M. Alkholy ◽  
Mohammed A. Abdou ◽  
Saeed M. Morsy ◽  
Hind M. Abdelrahman ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Tsegaw Yehuala ◽  
Ergoye Melese ◽  
Kassawmar Angaw Bogale ◽  
Baye Dagnew

Background. Implanon is a long-acting reversible contraceptive method that is 99% effective in preventing unintended pregnancy. Despite its effectiveness, the rate of Implanon discontinuation is high. In Ethiopia, there is limited information about determinants of Implanon discontinuation. Therefore, this study aimed to identify the determinants of Implanon discontinuation among women who used Implanon at Bahir Dar town health institutions. Methods. We employed an unmatched case-control study to find out the determinants of Implanon discontinuation at Bahir Dar town health institutions from March to June 2019 using the multistage stratified sampling technique to select study participants. Cases were women who had discontinued Implanon before completion of 3 years, and controls were women who had removed Implanon at the date of appointment (3 years). A pretested, structured questionnaire with face-to-face interviews was used. Binary logistic regression was performed to identify determinants of Implanon discontinuation. In the final model, variables with a p value of <0.05 were considered significant at 95% confidence interval and the strength of association was measured using odds ratio. Results. Primary education (AOR = 0.104, 95% CI (0.02–0.48)), secondary education (AOR = 0.48, 95% CI (0.24–0.952)), women who have no child (AOR = 2.04, 95% CI (1.2–3.4)), women who had no discussion with their partner (AOR = 2.2, 95% CI (1.39–3.57)), mass counseling (AOR = 3.5, 95% CI (1.75–7.01)), women who had no counseling about side effects (AOR = 1.7, 95% CI (1.07–2.07)), women who experienced side effects (AOR = 2.2, 95% CI (1.4–3.4)), and purpose of family planning use (AOR = 2.5, 95% CI (1.14–4.8)) were determinants of Implanon discontinuation. Conclusion. Implanon discontinuation is attributed by multifactorial involvement. Women’s educational status, nulliparity, no counseling, not informed of side effects, and no partner discussion are significant factors. Health sector stakeholders need to tailor counseling services at individual level to bolster family planning utilization until the desired time.


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