scholarly journals Selected clinical parameters and changes in cardiac morphology and function assessed by magnetic resonance imaging in patients with rheumatoid arthritis and ankylosing spondylitis without clinically apparent heart disease

2021 ◽  
Author(s):  
Wojciech Tański ◽  
Paweł Gać ◽  
Angelika Chachaj ◽  
Małgorzata Sobieszczańska ◽  
Rafał Poręba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Pericardial Fluid ◽  
Independent Effect ◽  
Left Ventricular Myocardium ◽  
Leukocyte Antigen ◽  
Independent Risk Factors ◽  
Occurrence Type

Abstract Background The aim of the study was to assess the relationship between the occurrence of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and the cardiac magnetic resonance (CMR) changes in people without clinically overt heart disease. Methods The study group consisted of 74 people (48.81 ± 11.35 years): 29 patients with RA, 23 patients with AS and 22 people from control group. Blood samples were taken to assess laboratory parameters, disease activity was determined using activity scales, and CMR was performed. Results It was shown that the factors independently related to higher left ventricular mass index are AS occurrence, human B27 leukocyte antigen occurrence, higher neutrophil gelatinase–associated lipocalin concentration (NGAL) and higher body mass index (BMI). The lower right ventricular ejection fraction is result of an independent effect of RA, AS and higher NGAL. RA presence, methotrexate use, higher rheumatoid factor titer, higher NGAL, older age and higher BMI should be considered independent risk factors for greater left ventricular myocardium water content. RA occurrence, AS occurrence, type 2 diabetes occurrence and a higher C-reactive protein concentration can be independently associated with a higher probability of non-ischemic left ventricular myocardium injury. Larger pericardial fluid volume is result of an independent effect of higher NGAL, higher anti-cyclic citrullinated peptide antibodies titer and higher DAS28 disease activity index. Use of steroids is protective factor against larger volume of pericardial fluid. Conclusions RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR. Key Points•RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR..•The independent risk factors for higher LVEF are AS occurrence, human B27 leukocyte antigen occurrence, higher NGAL concentration and higher BMI..•RA presence, methotrexate use, higher RF, higher NGAL, older age and higher BMI are independent risk factors for higher LV T2 ratio..•RA occurrence, AS occurrence, type 2 diabetes occurrence and a higher CRP are independently associated with a higher risk of non-ischemic LV myocardium injury..

Quality of Life of Patients With Ischemic Heart Disease and Pronounced Dysfunction of Left Ventricular Myocardium With Medical and Surgical Treatments

Kardiologiia ◽  
2015 ◽  
Vol 4_2015 ◽  
pp. 5-13
Author(s):  
A.M. Chernyavsky Chernyavsky ◽  
O.S. Efanova Efanova ◽  
V.U. Efendiyev Efendiyev ◽  
D.A. Sirota Sirota ◽  
E.M. Alyapkina Alyapkina ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Myocardium ◽  
Surgical Treatments

scholarly journals The physiological uptake pattern of 18F-FDG in the left ventricular myocardium of patients without heart disease

2014 ◽  
Vol 61 (1.2) ◽  
pp. 53-58 ◽  
Author(s):  
Hayato Nose ◽  
Hideki Otsuka ◽  
Yoichi Otomi ◽  
Kaori Terazawa ◽  
Shoichiro Takao ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Physiological Uptake ◽  
Uptake Pattern ◽  
18F Fdg

Dynamics of Structural – Functional State of the Left Ventricle in Patients with Hypertension and Chronic Ischemic Heart Disease on the Background of Gastroesophageal Reflux Disease Under the Influence of Antihypertensive and Antireflux Therapy

2016 ◽  
pp. 102-107
Author(s):  
Diana Moreva
Keyword(s):  
Heart Disease ◽  
Left Ventricle ◽  
Ischemic Heart Disease ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Ischemic Heart ◽  
Left Ventricular Myocardium ◽  
Chronic Ischemic Heart Disease ◽  
Concentric Hypertrophy ◽  
Antireflux Therapy

Diseases of the circulatory system are the most common pathology in Ukraine and cover 26,2 mln. Population 12,3 mln ukrainians suffer from hypertension (AH). Gastroesophageal reflux disease (GERD) is recognized by the World Organization of Gastroenterology disease of the XXI century. Given the common risk factors for hypertension coronary heart disease (CHD) and the question of GERD studies of the combined flow of these diseases and to optimize the treatment of these patients. The objective: to determine the characteristics of intracardiac hemodynamics in patients with hypertension combined with chronic ischemic heart disease on the background of GERD and the determination of the combined effects of antihypertensive and antireflux therapy on the structural-functional state of the left ventricular myocardium. Patients and methods. We examined 107 patients aged 44 to 78 years, with an established diagnosis of hypertension stage I and II in combination with chronic ischemic heart disease. Research methods included anthropometric studies, biochemical blood analysis, ambulatory blood pressure monitoring, the daily ECG monitoring, esophagogas-troduodenoscopy (EGD), echocardiography (echocardiography), testing. Results. Comorbidity for hypertension, chronic ischemic heart disease and GERD is associated with a higher frequency of abdominal type of obesity and the metabolic syndrome according to IDF criteria, significantly higher percentage of patients with grade II and III obesity. That in turn is reflected in the features of the structural1functional state of the left ventricle (LV), which manifests an increase in the number of patients with more severe degrees of left ventricular hypertrophy. Related GERD is associated with a large percentage of cases of concentric hypertrophy of the left ventricle, and a greater prevalence of diastolic dysfunction. The combination of antihypertensive and antireflux therapy for 12 weeks of treatment was reflected in the significant decrease in the weight of the index parameters of left ventricular myocardium (LVMI) and relative wall thickness index and reliable positive dynamics of indicators of left ventricular diastolic function. Conclusion. Patients with hypertension combined with chronic ischemic heart disease with comorbidity with GERD have a higher prevalence of factors of cardiovascular risk. Related GERD is associated with a more severe degree of left ventricular hypertrophy, with a large percentage of cases of concentric hypertrophy of the left ventricle, and a greater prevalence of diastolic dysfunction. A combination of antihypertensive and antireflux therapy for 12 weeks of treatment promoted significant reduction in myocardial mass index indicators LV (LVMI) and relative wall thickness index and had a significant impact on the normalization of LV diastolic function.

scholarly journals The use of methods of spatial displacement of the myocardial structure (speckle tracking) to determine the indications for coronary angiography in patients suffering from coronary heart disease

2020 ◽  
Vol 22 (2) ◽  
pp. 70-73
Author(s):  
A. N. Kuchmin ◽  
M. Y. Yaroslavtcev ◽  
N. V. Afendikov ◽  
E. P. Galova ◽  
K. B. Evsukov ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Angiography ◽  
Speckle Tracking ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Longitudinal Deformation ◽  
Spatial Displacement ◽  
Myocardial Structure

The indicators of global and segmental longitudinal deformation of the left ventricular myocardium are presented and analyzed in patients suffering from coronary heart disease. The latter, as before, remains one of the urgent diseases of the circulatory system. To verify and determine management tactics for patients suffering from coronary heart disease, coronary angiography is performed. Indications for its implementation are based on the results of exercise tests, in particular, stress echocardiography. However, its implementation can be difficult due to poor visualization of the walls of the left ventricle, and the conclusion is not without subjectivity. One of the modern methods for assessing the contractility of the left ventricular myocardium, both global and segmental, is the spatial displacement of the myocardial structure (speckle-tracking- echocardiography). The technique automatically calculates the longitudinal deformation of the myocardium, expressed as a percentage of the initial values. It was found that the global and segmental longitudinal deformation of the left ventricular myocardium in the majority of the evaluated segments in the examined patients did not differ before loading. When conducting a stress test, the exact opposite dynamics of changes in the parameters of the global and segmental longitudinal deformation of the left ventricular myocardium is observed. So, in patients with a high risk of complications of coronary heart disease, a decrease in these indicators was observed, in patients without a risk of complications, on the contrary, their increase was observed, which indicates an increase in myocardial contractility during physical exertion. It was revealed that the indicator of global longitudinal deformation of the left ventricular myocardium is highly informative. The lower value of the decrease in the global longitudinal deformation of the left ventricular myocardium was calculated, which can serve as an additional indication for coronary angiography.

scholarly journals Effects of Telmisartan on Myocardial Protein Profiles in Hypertensive Rats

2021 ◽  
Vol 34 (3) ◽  
pp. 299-299
Author(s):  
Yu Feng ◽  
Man-li Zhou ◽  
Jian-zhang Wang ◽  
Jia-qi Zhang ◽  
Shu-le Qian ◽  
...  
Keyword(s):  
Heat Shock ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Sterile Water ◽  
Protein Profiles ◽  
Related Protein ◽  
Hypertensive Rats ◽  
Treatment Groups ◽  
Proteasome 26S

Abstract Background To investigate the effects of telmisartan on the protein profiles of the left ventricular myocardium in spontaneously hypertensive rats (SHR). Methods Sixteen SHR were randomly divided into control and telmisartan treatment groups. Rats were treated with sterile water (10 ml/kg) or telmisartan (4.33 mg/kg) by gavage for 12 weeks. Wistar-Kyoto (WKY) rats treated with sterile water (10 ml/kg) as controls. At the end of 12 weeks of control or telmisartan treatment, rats were sacrificed, and hearts were collected for protein preparations, isotope labeling, and mass spectrometric analysis. Results In total, there were 23 differentially expressed proteins in the left ventricular myocardium between control and telmisartan treatment groups in SHR. Compared with the telmisartan group, the upregulated proteins in the SHR were dual-specificity mitogen-activated protein kinase kinase 3-like, transgelin, and haptoglobin subtype 2. The downregulated proteins in the SHR were as follows: von Willebrand factor (fragment), kininogen 1, small ribonucleoprotein-related protein, fibrinogen beta chain, protein mass 3 (fragment), proteasome 26s, heat shock protein 27-related protein 1, tenascin X, fibronectin subtype 2, transferrin receptor protein, platelets 1, cathepsin L1, complement factor B, isoform CRA_b, fibrinogen isomer, immunoglobulin heavy chain (γ polypeptide), and α 1 antiprotease. Conclusions Telmisartan differentially regulates myocardial protein expression in hypertensive rats including heat shock protein 27, fibrinogen, fibronectin, proteasome 26s and transgelin, as well as proteins in biochemical, metabolic, and signal transduction pathways. These changes in protein expression may contribute to the antihypertrophic effects of telmisartan in hypertension.

scholarly journals Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yankun Lyu ◽  
Vipin K. Verma ◽  
Younjee Lee ◽  
Iosif Taleb ◽  
Rachit Badolia ◽  
...  
Keyword(s):  
Heart Function ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Senescent Phenotype ◽  
Cellular Microstructure ◽  
T System

AbstractIt is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here, we show that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age. We shed light on mechanisms of this remodeling and identified similarities and differences to chronic HF. Using left ventricular myocardium from donors and HF patients with ages between 19 and 75 years, we established a library of 3D reconstructions of the t-system as well as ryanodine receptor (RyR) and junctophilin 2 (JPH2) clusters. Aging was characterized by t-system alterations and sarcolemmal dissociation of RyR clusters. This remodeling was less pronounced than in HF and accompanied by major alterations of JPH2 arrangement. Our study indicates that targeting sarcolemmal association of JPH2 might ameliorate age-associated deficiencies of heart function.

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