Angiographic Peculiarities and Brain Natriuretic Peptide Levels in Coronary Heart Disease Patients with Various Left Ventricular Myocardium Mass

The indicators of global and segmental longitudinal deformation of the left ventricular myocardium are presented and analyzed in patients suffering from coronary heart disease. The latter, as before, remains one of the urgent diseases of the circulatory system. To verify and determine management tactics for patients suffering from coronary heart disease, coronary angiography is performed. Indications for its implementation are based on the results of exercise tests, in particular, stress echocardiography. However, its implementation can be difficult due to poor visualization of the walls of the left ventricle, and the conclusion is not without subjectivity. One of the modern methods for assessing the contractility of the left ventricular myocardium, both global and segmental, is the spatial displacement of the myocardial structure (speckle-tracking- echocardiography). The technique automatically calculates the longitudinal deformation of the myocardium, expressed as a percentage of the initial values. It was found that the global and segmental longitudinal deformation of the left ventricular myocardium in the majority of the evaluated segments in the examined patients did not differ before loading. When conducting a stress test, the exact opposite dynamics of changes in the parameters of the global and segmental longitudinal deformation of the left ventricular myocardium is observed. So, in patients with a high risk of complications of coronary heart disease, a decrease in these indicators was observed, in patients without a risk of complications, on the contrary, their increase was observed, which indicates an increase in myocardial contractility during physical exertion. It was revealed that the indicator of global longitudinal deformation of the left ventricular myocardium is highly informative. The lower value of the decrease in the global longitudinal deformation of the left ventricular myocardium was calculated, which can serve as an additional indication for coronary angiography.

Download Full-text

Selected clinical parameters and changes in cardiac morphology and function assessed by magnetic resonance imaging in patients with rheumatoid arthritis and ankylosing spondylitis without clinically apparent heart disease

Clinical Rheumatology ◽

10.1007/s10067-021-05777-6 ◽

2021 ◽

Author(s):

Wojciech Tański ◽

Paweł Gać ◽

Angelika Chachaj ◽

Małgorzata Sobieszczańska ◽

Rafał Poręba ◽

...

Keyword(s):

Risk Factors ◽

Heart Disease ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Pericardial Fluid ◽

Independent Effect ◽

Left Ventricular Myocardium ◽

Leukocyte Antigen ◽

Independent Risk Factors ◽

Occurrence Type

Abstract Background The aim of the study was to assess the relationship between the occurrence of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and the cardiac magnetic resonance (CMR) changes in people without clinically overt heart disease. Methods The study group consisted of 74 people (48.81 ± 11.35 years): 29 patients with RA, 23 patients with AS and 22 people from control group. Blood samples were taken to assess laboratory parameters, disease activity was determined using activity scales, and CMR was performed. Results It was shown that the factors independently related to higher left ventricular mass index are AS occurrence, human B27 leukocyte antigen occurrence, higher neutrophil gelatinase–associated lipocalin concentration (NGAL) and higher body mass index (BMI). The lower right ventricular ejection fraction is result of an independent effect of RA, AS and higher NGAL. RA presence, methotrexate use, higher rheumatoid factor titer, higher NGAL, older age and higher BMI should be considered independent risk factors for greater left ventricular myocardium water content. RA occurrence, AS occurrence, type 2 diabetes occurrence and a higher C-reactive protein concentration can be independently associated with a higher probability of non-ischemic left ventricular myocardium injury. Larger pericardial fluid volume is result of an independent effect of higher NGAL, higher anti-cyclic citrullinated peptide antibodies titer and higher DAS28 disease activity index. Use of steroids is protective factor against larger volume of pericardial fluid. Conclusions RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR. Key Points•RA and AS in people without clinically apparent heart disease are associated with the occurrence of adverse changes in CMR..•The independent risk factors for higher LVEF are AS occurrence, human B27 leukocyte antigen occurrence, higher NGAL concentration and higher BMI..•RA presence, methotrexate use, higher RF, higher NGAL, older age and higher BMI are independent risk factors for higher LV T2 ratio..•RA occurrence, AS occurrence, type 2 diabetes occurrence and a higher CRP are independently associated with a higher risk of non-ischemic LV myocardium injury..

Download Full-text

Efficacy and Safety of TCMI in Patients With Combined Coronary Heart Disease and Heart Failure: A Systematic Review and Network Meta-Analysis

Frontiers in Pharmacology ◽

10.3389/fphar.2021.741261 ◽

2021 ◽

Vol 12 ◽

Author(s):

Penglu Wei ◽

Kuo Yang ◽

Dehuai Long ◽

Yupei Tan ◽

Wenlong Xing ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Coronary Heart Disease ◽

Heart Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Meta Analysis ◽

Controlled Trials ◽

Efficacy And Safety ◽

Effectiveness Rate

Objective: To compare the efficacy and safety of conventional treatments (CTs) to those that included traditional Chinese medicine injections (TCMIs) in patients with combined coronary heart disease and heart failure (CHD-HF).Methods: Eight electronic literature databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure Database, Chinese Scientific Journal Database, Wanfang Database, Chinese Biomedical Database) were searched from their inceptions to May 18, 2021, to identify relevant randomised controlled trials (RCTs). The primary outcomes analyzed included the total effectiveness rate and adverse events (ADRs). The secondary outcomes analyzed included the left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP), and 6-min walk test (6MWT). Cochrane risk-of-bias tool was used to assess quality of the analyzed RCTs. Stata and OpenBUGS software were used to prior to the systematic review and network meta-analysis.Results: Sixty-one eligible trials involved 5,567 patients and one of the following 15 TCMIs: Shuxuetong, Shenmai, Shenfu, Shengmai, Danshenduofenyansuan, Danhong, Dazhuhongjingtian, Xinmailong, Dengzhanxixin, Gualoupi, Shuxuening, Xuesaitong, Yiqi Fumai, Shenqi Fuzheng, Huangqi. Network meta-analysis revealed that Shuxuetong injection + CT group was superior to CT only in improving the total effectiveness rate [odds ratio (OR): 7.8, 95% confidence interval (CI): 1.17–27.41]. Shenmai injection + CT was superior to CT only for LVEF (OR: 8.97, CI: 4.67–13.18), Xinmailong injection + CT was superior to CT only for NT-proBNP (OR: −317.70, CI: −331.10–303.10), Shenqi Fuzheng injection + CT was superior to CT only for BNP (OR: −257.30, CI: −308.40–242.80); and Danhong injection + CT was superior to CT only for 6MWT (OR: 84.40, CI: 62.62−106.20). Different TCMIs had different toxicity spectrums.Conclusion: TCMIs combined with CT are better than CT alone in treating CHD-HF. Different TCMIs improve different outcomes. Additional properly designed RCTs are needed to conduce a more refined comparison of various TCMIs.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021258263].

Download Full-text

NT pro- B-type Natriuretic Peptide in the Small Ventricular Septal Defect in Children

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.7592 ◽

2021 ◽

Vol 9 (B) ◽

pp. 1677-1680

Author(s):

Rahmat Budi Kuswiyanto ◽

Putria Apandi ◽

Dany Hilmanto ◽

Muhammad Hasan Bashari ◽

Sri Endah Rahayuningsih

Keyword(s):

Natriuretic Peptide ◽

Transcatheter Closure ◽

Volume Overload ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Left Ventricular Myocardium ◽

Natriuretic Peptide Level ◽

Peptide Level ◽

Before And After ◽

Male Patients

Background: Brain natriuretic peptide is a cardiac hormone secreted from the left ventricular myocardium due to ventricular expansion and volume overload. A recent study shows that small VSD will have risk of ventricular dysfunction in adulthood. Another complications such as endocarditis, congestive heart failure, aortic regurgitation, arrhythmia also we should be aware. Evaluations of the plasma B-type natriuretic peptide level (NT pro BNP) are currently being considered as methods to identify the possible presence of ventricular dilation in small VSD. Objective: To evaluate the change in plasma B-type natriuretic peptide after transcatheter closure of VSD. Methods: A pretest-posttest design was conducted on VSD patients before and after transcatheter closure. Plasma B-type natriuretic peptide level were measured before and 30 days after the transcatheter closure of VSD. Result: A total of 32 peri membranous VSD patients were included in this study with 62.5 % female patients (n=20) and 37.5 % male patients (n=12). A significant decrease was observed in the median NT pro BNP level when the level before closure of 1.08 (0.74 – 3.47) ng/ml was compared to the level after closure of 0.91 (0.68 – 2.07) ng/ml (p<0.05). Conclusion: Significant decreases in NT pro BNP level are seen in small VSD patients 30 days after transcatheter closure. Patients with small peri membranous VSD are generally considered to need occlusion for their childhood defect.

Download Full-text

Relationship between cardio-ankle vascular index and N-Terminal pro-brain natriuretic peptide in hypertension and coronary heart disease subjects

Journal of the American Society of Hypertension ◽

10.1016/j.jash.2014.03.041 ◽

2014 ◽

Vol 8 (4) ◽

pp. e23

Author(s):

Hongyu Wang ◽

Jinbo Liu ◽

Hongwei Zhao ◽

Yingyan Zhou ◽

Xujing Zhao ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide

Download Full-text

A patient with abnormalities of the coronary arteries and non-compaction of the left ventricular myocardium resulting in ischaemic heart disease symptoms

Folia Morphologica ◽

10.5603/fm.2015.0117 ◽

2015 ◽

Vol 74 (4) ◽

pp. 518-523 ◽

Cited By ~ 1

Author(s):

J. Dąbek ◽

M. Majewski ◽

W. Walkowicz ◽

Z. Gąsior

Keyword(s):

Heart Disease ◽

Ischaemic Heart Disease ◽

Coronary Arteries ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Left Ventricular Myocardium ◽

Disease Symptoms

Download Full-text

Quality of Life of Patients With Ischemic Heart Disease and Pronounced Dysfunction of Left Ventricular Myocardium With Medical and Surgical Treatments

Kardiologiia ◽

10.18565/cardio.2015.4.5-13 ◽

2015 ◽

Vol 4_2015 ◽

pp. 5-13

Author(s):

A.M. Chernyavsky Chernyavsky ◽

O.S. Efanova Efanova ◽

V.U. Efendiyev Efendiyev ◽

D.A. Sirota Sirota ◽

E.M. Alyapkina Alyapkina ◽

...

Keyword(s):

Quality Of Life ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Ventricular Myocardium ◽

Left Ventricular ◽

Ischemic Heart ◽

Left Ventricular Myocardium ◽

Surgical Treatments

Download Full-text

Serial Measurements of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Coronary Heart Disease

PLoS ONE ◽

10.1371/journal.pone.0117143 ◽

2015 ◽

Vol 10 (1) ◽

pp. e0117143 ◽

Cited By ~ 4

Author(s):

Dhayana Dallmeier ◽

Michael J. Pencina ◽

Iris Rajman ◽

Wolfgang Koenig ◽

Dietrich Rothenbacher ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Serial Measurements

Download Full-text

Association between N-terminal pro-brain natriuretic peptide and quality of life in adult patients with congenital heart disease

Cardiology in the Young ◽

10.1017/s1047951113002114 ◽

2013 ◽

Vol 25 (2) ◽

pp. 288-294 ◽

Cited By ~ 5

Author(s):

John O. Younge ◽

Jannet A. Eindhoven ◽

Elisabeth W. M. J. Utens ◽

Petra Opić ◽

Judith A. A. E. Cuypers ◽

...

Keyword(s):

Quality Of Life ◽

Congenital Heart Disease ◽

Heart Disease ◽

Health Status ◽

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Physical Functioning ◽

Congenital Heart ◽

Left Ventricular

AbstractAims: Advances in medical treatment have resulted in increased life expectancy in congenital heart disease. Consequently, the focus of management has shifted from reducing mortality to reducing long-term morbidity with the goal of improving quality of life. A predictor of quality of life might be N-terminal pro-brain natriuretic peptide, a well-established marker for heart failure. We aimed to determine the association between N-terminal pro-brain natriuretic peptide and quality of life in patients with congenital heart disease. Methods: We collected blood samples from consecutive patients who were initially operated between 1968 and 1980 (47.8% women; mean age 40.2±5.4 years). The 36-item Short-Form Health Survey was completed to assess subjective health status as a measure of quality of life. Analysis was performed for the entire group and for subgroups defined as simple versus complex congenital heart diseases. Median N-terminal pro-brain natriuretic peptide level was 15.2 pmol/L (overall range 1.3–299.3 pmol/L). N-terminal pro-brain natriuretic peptide levels were associated with the subdomain physical functioning (β=−0.074, p=0.031). This association remained significant after adjustment for age and sex (β=−0.071, p=0.038) and after adjustment for age, sex, body mass index, left ventricular function, and renal function (β=−0.069, p=0.048). In complex congenital heart disease, the association between N-terminal pro-brain natriuretic peptide and physical functioning remained significant in multivariable analysis (β=−0.076, p=0.046). No associations were found in the simple congenital heart disease group or on the other health status subdomains. Conclusion: In adults operated for congenital heart disease, N-terminal pro-brain natriuretic peptide is associated with the subdomain physical, primarily in the complex subgroup.

Download Full-text