Effect of far infrared drying on antioxidant property, anti-inflammatory activity, and inhibitory activity in A549 cells of Gamguk (Chrysanthemum indicum L.) flower

: Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs, inhibiting endotoxin-mediated release of HMGB1 by endothelial cells or regulating MAPK, PI3K/Akt/NF-κB/ICAM-1/JAK/STAT signaling pathways, etc. In recent years, an increased number of interesting research work has been carried out on the anti-inflammatory activity and mechanisms of OA derivatives, such as acyloxyimino derivative, 3-acetylated derivatives, novel 3,5-disubstituted isoxazoles derivatives, acetate, ester derivatives and oximes derivatives. The review summaries and highlights the update advances on the anti-inflammatory activity and mechanism of OA and its derivatives.

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Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity

Biochemical Pharmacology ◽

10.1016/j.bcp.2007.11.002 ◽

2008 ◽

Vol 75 (5) ◽

pp. 1045-1053 ◽

Cited By ~ 100

Author(s):

Wai Mun Loke ◽

Julie M. Proudfoot ◽

Scott Stewart ◽

Allan J. McKinley ◽

Paul W. Needs ◽

...

Keyword(s):

Inhibitory Activity ◽

Inflammatory Activity ◽

Metabolic Transformation ◽

Anti Inflammatory

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Study on the Molecular Structure and Bio-Activity (DNA Polymerase Inhibitory Activity, Anti-Inflammatory Activity and Anti-Oxidant Activity) Relationship of Curcumin Derivatives

Current Bioactive Compounds ◽

10.2174/157340707781695488 ◽

2007 ◽

Vol 3 (3) ◽

pp. 171-177 ◽

Cited By ~ 11

Author(s):

Yoshiyuki Mizushina ◽

Toshifumi Takeuchi ◽

Kouji Kuramochi ◽

Susumu Kobayashi ◽

Fumio Sugawara ◽

...

Keyword(s):

Molecular Structure ◽

Dna Polymerase ◽

Inhibitory Activity ◽

Inflammatory Activity ◽

Activity Relationship ◽

Curcumin Derivatives ◽

Anti Oxidant ◽

Anti Inflammatory ◽

Relationship Of

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IN VITRO ANTI-INFLAMMATORY ACTIVITY OF 4-BENZYLPIPERIDINE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2016.v9s2.12623 ◽

2016 ◽

pp. 108 ◽

Cited By ~ 1

Author(s):

Jayashree V ◽

Bagyalakshmi S ◽

Manjula Devi K ◽

Richard Daniel D

Keyword(s):

Inhibitory Activity ◽

Protein Denaturation ◽

In Vitro Models ◽

Inflammatory Activity ◽

Significant Activity ◽

Standard Drug ◽

Study Results ◽

Anti Inflammatory ◽

Dose Dependent

ABSTRACT Objective: To study the in vitro anti-inflammatory activity of 4-benzylpiperidine. Methods: This study was conducted to evaluate the in vitro anti-inflammatory activity of 4-benzylpiperidine using in vitro models such as inhibition of albumin denaturation and proteinase inhibitory activity. Results: This study revealed the dose-dependent inhibition of protein denaturation and proteinase inhibitory activity by 4-benzylpiperidine. Conclusion: In the present study, results indicate that the 4-benzylpiperidine possess anti-inflammatory properties. The drug inhibited the heat induced albumin denaturation and proteinase inhibitory activity. It shows dose-dependent significant activity when compared with a standard drug. Hence, this study gives an idea that the 4-benzylpiperidine can be used as a lead compound for designing a potent anti-inflammatory drug which can be used to cure inflammation. Keywords: Anti-inflammatory activity, 4-Benzylpiperidine, Protein denaturation, Proteinase inhibitory activity.

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Relationship between the Inhibitory Activity on 'RCS' and Prostaglandins Synthesis and the Anti-Inflammatory Activity of Ketoprofen and Several other Non-Steroidal Anti-Inflammatory Agents

Rheumatology ◽

10.1093/rheumatology/15.5.11 ◽

1976 ◽

Vol 15 (5) ◽

pp. 11-14 ◽

Cited By ~ 9

Author(s):

J. C. Guyonnet ◽

L. Julou

Keyword(s):

Inhibitory Activity ◽

Inflammatory Activity ◽

Anti Inflammatory

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ANTI-INFLAMMATORY ACTIVITY OF SYZYGIUM AROMATICUM SILVER NANOPARTICLES: IN VITRO AND IN SILICO STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i11.19904 ◽

2017 ◽

Vol 10 (11) ◽

pp. 370 ◽

Cited By ~ 2

Author(s):

Reslee Elsa Varghese ◽

Ragavan D ◽

Saranya Sivaraj ◽

Dasararaju Gayathri ◽

Gomathi Kannayiram

Keyword(s):

Silver Nanoparticles ◽

Aqueous Extract ◽

In Silico ◽

Protein Denaturation ◽

Interleukin 1 ◽

Antioxidant Property ◽

Inflammatory Activity ◽

Enzyme Linked Immunosorbent Assay ◽

Syzygium Aromaticum ◽

Anti Inflammatory

Objective: In the present study, antioxidant and anti-inflammatory activity of Syzygium aromaticum (clove) silver nanoparticles (clove AgNP’s) was evaluated.Methods: Gas chromatography-mass spectrometry technique was used to identify the compounds present in the aqueous extract of clove. Fourier transform infrared (FT-IR) analysis was done to characterize the clove silver AgNP’s. 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was performed to evaluate the antioxidant property of nanoparticles (0.05 and 0.25 mg/ml) and aqueous extracts (0.05, 0.1, and 0.25 mg/ml) of clove. The anti-inflammatory property of the clove AgNP’s was determined by inhibition of protein denaturation and downregulation of interleukin-1 beta. In silico molecular docking studies was performed using Schrodinger Maestro software.Results: Eugenol was found to be highest with 16.27%. The AgNP’s exhibited dose-dependent antioxidant property. AgNP’s scavenged 80% of radical at the concentration of 0.25 mg/ml. The scavenging activity of AgNP’s markedly increased when compared to aqueous extract at the same concentration. Inhibition of protein denaturation assay also revealed AgNP’s showing the highest activity (66%) when compared with drug aspirin (55%) and aqueous extract (56%). In the enzyme-linked immunosorbent assay (ELISA) method, AgNP’s showed better inhibition (80%) when compared to aqueous extract (60%). Among 15 compounds, two compounds (eugenol and methyl 14-methylpentadecanoate) showed good glide energy, docking score, and hydrogen-bonded active site interactions with the protein interleukin-1 beta.Conclusion: As AgNP’s were more active than the aqueous extract, it may be considered for pharmacological activity against inflammatory disorders.

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