Protective effect of butanol extracts of skin of Anguilla japonica against endoplasmic reticulum stress-induced insulin resistance via the AMPK pathway in L6 myotubes

2015 ◽  
Vol 24 (3) ◽  
pp. 1069-1075
Author(s):  
Min Kyun Na ◽  
Yong-Tae Jeong ◽  
Xian Li ◽  
Fansi Jin ◽  
Seung-Lark Hwang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Anguilla Japonica ◽  
Ampk Pathway ◽  
L6 Myotubes

Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes

2013 ◽  
Vol 24 (6) ◽  
pp. 1053-1061 ◽  
Author(s):  
Eun-Kyung Yoon ◽  
Yong-Tae Jeong ◽  
Xian Li ◽  
Song-Cui ◽  
Dong-Chan Park ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Ampk Pathway ◽  
L6 Myotubes

Testicular Injury Attenuated by Rapamycin Through Induction of Autophagy and Inhibition of Endoplasmic Reticulum Stress in Streptozotocin- Induced Diabetic Rats

2019 ◽  
Vol 19 (5) ◽  
pp. 665-675 ◽  
Author(s):  
Wenjiao Shi ◽  
Zhixin Guo ◽  
Ruixia Yuan
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
Er Stress ◽  
B Cell Lymphoma ◽  
Diabetic Rats ◽  
Pathological Changes ◽  
Rapamycin Treatment ◽  
Related Proteins

Background and Objective: This study investigated whether rapamycin has a protective effect on the testis of diabetic rats by regulating autophagy, endoplasmic reticulum stress, and oxidative stress. Methods: Thirty male Sprague-Dawley rats were randomly divided into three groups: control, diabetic, and diabetic treated with rapamycin, which received gavage of rapamycin (2mg.kg-1.d-1) after induction of diabetes. Diabetic rats were induced by intraperitoneal injection of streptozotocin (STZ, 65mg.Kg-1). All rats were sacrificed at the termination after 8 weeks of rapamycin treatment. The testicular pathological changes were determined by hematoxylin and eosin staining. The protein or mRNA expression of autophagy-related proteins (Beclin1, microtubule-associated protein light chain 3 (LC3), p62), ER stress marked proteins (CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), caspase-12), oxidative stress-related proteins (p22phox, nuclear factor erythroid2-related factor 2 (Nrf2)) and apoptosis-related proteins (Bax, B cell lymphoma-2 (Bcl-2)) were assayed by western blot or real-time fluorescence quantitative PCR. Results: There were significant pathological changes in the testes of diabetic rats. The expression of Beclin1, LC3, Nrf2, Bcl-2 were significantly decreased and p62, CHOP, caspase12, p22phox, and Bax were notably increased in the testis of diabetic rats (P <0.05). However, rapamycin treatment for 8 weeks significantly reversed the above changes in the testis of diabetic rats (P <0.05). Conclusion: Rapamycin appears to produce a protective effect on the testes of diabetic rats by inducing the expression of autophagy and inhibiting the expression of ER-stress, oxidative stress, and apoptosis.

DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance

2018 ◽  
Vol 123 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Omar Ramos-Lopez ◽  
Jose I. Riezu-Boj ◽  
Fermin I. Milagro ◽  
J. Alfredo Martinez
Keyword(s):  
Insulin Resistance ◽  
Dna Methylation ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Stress Genes

scholarly journals The role of endoplasmic reticulum stress in hippocampal insulin resistance

2016 ◽  
Vol 277 ◽  
pp. 261-267 ◽  
Author(s):  
Catrina Sims-Robinson ◽  
Anna Bakeman ◽  
Rebecca Glasser ◽  
Janet Boggs ◽  
Crystal Pacut ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

Phosphocreatine attenuates endoplasmic reticulum stress-mediated hepatocellular apoptosis ameliorates insulin resistance in diabetes model

2018 ◽  
Vol 506 (3) ◽  
pp. 611-618 ◽  
Author(s):  
Yazeed Jamalat ◽  
Yaser Gamallat ◽  
Pires Sanches Jaceline Gislaine ◽  
Abdo Meyiah ◽  
Abdullah Shopit ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Diabetes Model ◽  
Hepatocellular Apoptosis

Protective effect of curcumin against high glucose-induced endoplasmic reticulum stress by downregulation of COX-2 expression in huvecs

2008 ◽  
Vol 32 (3) ◽  
pp. S14-S14
Author(s):  
Ying Fan ◽  
Xiang Hong Meng ◽  
Wen Liang Chen ◽  
Li Zhu ◽  
Yue Liang Shen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Protective Effect ◽  
High Glucose ◽  
Cox 2

Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice

2018 ◽  
Vol 122 ◽  
pp. 87-94 ◽  
Author(s):  
Chan-Min Liu ◽  
Hui-Xin Yang ◽  
Jie-Qiong Ma ◽  
Wei Yang ◽  
Zhao-Jun Feng ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Ampk Pathway
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