Low levels of mannose-binding lectin confers protection against tuberculosis in Turkish children

2008 ◽  
Vol 27 (12) ◽  
pp. 1165-1169 ◽  
Author(s):  
H. Cosar ◽  
F. Ozkinay ◽  
H. Onay ◽  
N. Bayram ◽  
A. R. Bakiler ◽  
...  
Keyword(s):  
Mannose Binding Lectin ◽  
Turkish Children ◽  
Mannose Binding ◽  
Low Levels ◽  
Binding Lectin

Mannose-binding lectin gene (MBL2) polymorphisms related to the mannose-binding lectin low levels are associated to dengue disease severity

2016 ◽  
Vol 77 (7) ◽  
pp. 571-575 ◽  
Author(s):  
Gabriela G. Figueiredo ◽  
Renata D. Cezar ◽  
Naishe M. Freire ◽  
Vanessa G. Teixeira ◽  
Paulo Baptista ◽  
...  
Keyword(s):  
Disease Severity ◽  
Mannose Binding Lectin ◽  
Dengue Disease ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Low Levels ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Binds to a Range of Clinically Relevant Microorganisms and Promotes Complement Deposition

2000 ◽  
Vol 68 (2) ◽  
pp. 688-693 ◽  
Author(s):  
Olaf Neth ◽  
Dominic L. Jack ◽  
Alister W. Dodds ◽  
Helen Holzel ◽  
Nigel J. Klein ◽  
...  
Keyword(s):  
Immune Defense ◽  
Mannose Binding Lectin ◽  
Dependent Manner ◽  
Group B Streptococci ◽  
Concentration Dependent Manner ◽  
Mannose Binding ◽  
Low Levels ◽  
Serum Lectin ◽  
Group B ◽  
Binding Lectin

ABSTRACT Mannose-binding lectin (MBL) is a collagenous serum lectin believed to be of importance in innate immunity. Genetically determined low levels of the protein are known to predispose to infections. In this study the binding of purified MBL to pathogens isolated from immunocompromised children was investigated by flow cytometry. DiverseCandida species, Aspergillus fumigatus,Staphylococcus aureus, and beta-hemolytic group A streptococci exhibited strong binding of MBL, whereas Escherichia coli, Klebsiella species, and Haemophilus influenzae type b were characterized by heterogeneous binding patterns. In contrast, beta-hemolytic group B streptococci,Streptococcus pneumoniae, and Staphylococcus epidermidis showed low levels of binding. Bound MBL was able to promote C4 deposition in a concentration-dependent manner. We conclude that MBL may be of importance in first-line immune defense against several important pathogens.

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