Association of serum adiponectin level with albuminuria in chronic kidney disease patients

2015 ◽  
Vol 20 (3) ◽  
pp. 443-449 ◽  
Author(s):  
Ha Yeon Kim ◽  
Eun Hui Bae ◽  
Seong Kwon Ma ◽  
Dong Wan Chae ◽  
Kyu Hun Choi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level

scholarly journals Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease

2022 ◽  
Vol 8 ◽  
Author(s):  
Sang Heon Suh ◽  
Tae Ryom Oh ◽  
Hong Sang Choi ◽  
Chang Seong Kim ◽  
Joongyub Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Adiponectin Level ◽  
High Serum ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level ◽  
Increased Risk ◽  
All Cause Mortality

Background: Serum adiponectin level predicts cardiovascular (CV) outcomes and progression of coronary artery calcification (CAC) in the general population, although the association has not been validated in patients with chronic kidney disease (CKD). In this study, we investigated the association of high serum adiponectin level with the risk of adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.Methods: A total of 1,127 patients with pre-dialysis CKD from a nationwide prospective cohort of patients with pre-dialysis CKD in Korea were divided into the tertile by serum adiponectin level at the baseline. CV outcome of interest was fatal and non-fatal CV events and all-cause mortality. Progression of CAC was defined as coronary artery calcium score (CACS) change more than 200 during a 4-year follow-up.Results: Cox regression analysis revealed that high serum adiponectin is associated with increased risk of fatal and non-fatal CV events (adjusted hazard ratio 2.799, 95% CI 1.348–5.811). In contrast, high serum adiponectin level was not significantly associated with all-cause mortality (adjusted hazard ratio 0.655, 95% CI 0.203–2.113). Binary logistic regression analysis revealed that high serum adiponectin level is also associated with increased risk of progression of CAC (adjusted odds ratio [OR] 2.078, 95% CI 1.014–4.260). Subgroup analyses demonstrated that the association of high serum adiponectin with increased risk of fatal and non-fatal CV events is not modified by age, gender, history of diabetes, estimated glomerular filtration rate (eGFR), or spot urine albumin-to-creatinine ratio (ACR).Conclusions: High serum adiponectin level is associated with adverse CV outcomes and progression of CAC in patients with pre-dialysis CKD.

scholarly journals Low serum adiponectin level is associated with better physical health-related quality of life in chronic kidney disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji Hye Kim ◽  
◽  
Ji Min Han ◽  
Hyang Kim ◽  
Kyu-Beck Lee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Health Related Quality ◽  
Serum Adiponectin Level ◽  
Related Quality ◽  
Health Related

AbstractHyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1–T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09–2.23] and 1.19 [0.85–1.68] for high PCS and 1.19 [0.85–1.68] and 0.94 [0.68–1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.

scholarly journals Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females

2020 ◽  
Vol 95 (1) ◽  
Author(s):  
Walaa H. Foula ◽  
Rana H. Emara ◽  
Mona K. Eldeeb ◽  
Samiha A. Mokhtar ◽  
Fikrat A. El-Sahn
Keyword(s):  
Public Health ◽  
Insulin Resistance ◽  
Weight Loss ◽  
Adiponectin Level ◽  
Normal Weight ◽  
Weight Loss Program ◽  
Serum Adiponectin ◽  
Health Clinic ◽  
Serum Adiponectin Level ◽  
Health Crisis

Abstract Background Obesity has emerged as a public health crisis in many populations including Egypt. Adipose tissue produces a number of adipokines, one of them is adiponectin which has attracted much attention because of its antidiabetic and antiatherogenic effects. Objective To determine the effect of a weight loss program on serum adiponectin level and insulin resistance among overweight and obese adult premenopausal females. Study design A pre-postintervention study was carried out among 95 premenopausal overweight and obese females (body mass index ≥ 25 kg/m2) aged 20 to 40 years at the integrated health clinic affiliated to the High Institute of Public Health, Alexandria, Egypt, from February 2016 to February 2017. All participants underwent a weight loss program based on a reduced calorie balanced diet and advised to increase their physical activity. Dietary instructions and follow-up were done weekly throughout 16 weeks. Blood samples were collected to investigate serum adiponectin level and insulin resistance at the beginning and the end of the intervention. Results After 16 weeks, a significant decrease in body weight by 9.7% was associated with a significant increase in serum adiponectin from 13.3 ± 4.9 μg/ml to 18.5 ± 5.6 μg/ml. Both fasting insulin and insulin resistance had decreased significantly by 13.6% and 13.7%, respectively. Conclusion A weight reduction program depending on a reduced calorie diet for 16 weeks was associated with a significant increase in total adiponectin level and reduction in insulin resistance. An emphasis on the importance of keeping normal weight through nutritional education and the promotion of healthy diets is recommended to reduce the risk of occurrence of insulin resistance, type 2 diabetes, and cardiovascular diseases.

scholarly journals Effect of Glimepiride on Serum Adiponectin Level in Subjects With Type 2 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (7) ◽  
pp. 2215-2216 ◽  
Author(s):  
S. Nagasaka ◽  
A. Taniguchi ◽  
Y. Aiso ◽  
T. Yatagai ◽  
T. Nakamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adiponectin Level ◽  
Serum Adiponectin ◽  
Serum Adiponectin Level
Sign in / Sign up

Export Citation Format

Share Document