scholarly journals Sox2 Up-regulation and Glial Cell Proliferation Following Degeneration of Spiral Ganglion Neurons in the Adult Mouse Inner Ear

2010 ◽  
Vol 12 (2) ◽  
pp. 151-171 ◽  
Author(s):  
Hainan Lang ◽  
Manna Li ◽  
Lauren A. Kilpatrick ◽  
Juhong Zhu ◽  
Devadoss J. Samuvel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Inner Ear ◽  
Glial Cell ◽  
Adult Mouse ◽  
Spiral Ganglion ◽  
Spiral Ganglion Neurons ◽  
Glial Cell Proliferation ◽  
Ganglion Neurons

scholarly journals Renewed proliferation in adult mouse cochlea and regeneration of hair cells

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Yilai Shu ◽  
Wenyan Li ◽  
Mingqian Huang ◽  
Yi-Zhou Quan ◽  
Deborah Scheffer ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Adult Mouse ◽  
Spiral Ganglion ◽  
Cell Types ◽  
Spiral Ganglion Neurons ◽  
Supporting Cells ◽  
Styryl Dye ◽  
Co Activation ◽  
Ganglion Neurons

AbstractThe adult mammalian inner ear lacks the capacity to divide or regenerate. Damage to inner ear generally leads to permanent hearing loss in humans. Here, we present that reprogramming of the adult inner ear induces renewed proliferation and regeneration of inner ear cell types. Co-activation of cell cycle activator Myc and inner ear progenitor gene Notch1 induces robust proliferation of diverse adult cochlear sensory epithelial cell types. Transient MYC and NOTCH activities enable adult supporting cells to respond to transcription factor Atoh1 and efficiently transdifferentiate into hair cell-like cells. Furthermore, we uncover that mTOR pathway participates in MYC/NOTCH-mediated proliferation and regeneration. These regenerated hair cell-like cells take up the styryl dye FM1-43 and are likely to form connections with adult spiral ganglion neurons, supporting that Myc and Notch1 co-activation is sufficient to reprogram fully mature supporting cells to proliferate and regenerate hair cell-like cells in adult mammalian auditory organs.

Substance P inhibits potassium and calcium currents in inner ear spiral ganglion neurons

2004 ◽  
Vol 1012 (1-2) ◽  
pp. 82-92 ◽  
Author(s):  
Wei Sun ◽  
Da-Lian Ding ◽  
Ping Wang ◽  
Jianhe Sun ◽  
Xiaojie Jin ◽  
...  
Keyword(s):  
Substance P ◽  
Inner Ear ◽  
Spiral Ganglion ◽  
Calcium Currents ◽  
Spiral Ganglion Neurons ◽  
Ganglion Neurons
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