Association between HER2 and IL-6 genes polymorphisms and clinicopathological characteristics of breast cancer: significant role of genetic variability in specific breast cancer subtype

2020 ◽  
Vol 20 (3) ◽  
pp. 427-436
Author(s):  
Om Elez Bouhniz ◽  
Sonia Zaied ◽  
Lamia Naija ◽  
Ilhem Bettaieb ◽  
Khaled Rahal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variability ◽  
Significant Role ◽  
Breast Cancer Subtype ◽  
Clinicopathological Characteristics ◽  
Cancer Subtype

scholarly journals p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

2019 ◽  
Vol 20 (11) ◽  
pp. 2683 ◽  
Author(s):  
Veronica Gatti ◽  
Lucilla Bongiorno-Borbone ◽  
Claudia Fierro ◽  
Margherita Annicchiarico-Petruzzelli ◽  
Gerry Melino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Breast Cancer Subtype ◽  
Physiological Role ◽  
The Past ◽  
Cancer Breast ◽  
Incidence And Mortality ◽  
Cancer Subtype ◽  
Screening Approaches

After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, triple-negative breast cancer (TNBC) remains the breast cancer subtype that displays the worst prognosis, mainly due to the lack of clinically actionable targets. Genetic and molecular profiling has unveiled the high intrinsic heterogeneity of TNBC, with the basal-like molecular subtypes representing the most diffuse TNBC subtypes, characterized by the expression of basal epithelial markers, such as the transcription factor p63. In this review, we will provide a broad picture on the physiological role of p63, in maintaining the basal epithelial identity, as well as its involvement in breast cancer progression, emphasizing its relevance in tumor cell invasion and stemness.

scholarly journals Prognostic Role of Interleukin-6, Interleukin-8, and Leptin Levels According to Breast Cancer Subtype

2013 ◽  
Vol 45 (3) ◽  
pp. 210-219 ◽  
Author(s):  
Young Ae Cho ◽  
Mi-Kyung Sung ◽  
Jee-Young Yeon ◽  
Jungsil Ro ◽  
Jeongseon Kim
Keyword(s):  
Breast Cancer ◽  
Interleukin 6 ◽  
Breast Cancer Subtype ◽  
Interleukin 8 ◽  
Prognostic Role ◽  
Cancer Subtype

scholarly journals The Role of Ki67 in Evaluating Neoadjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Ailin Zhang ◽  
Xiaojing Wang ◽  
Chuifeng Fan ◽  
Xiaoyun Mao
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Breast Cancer Subtype ◽  
Predictive Marker ◽  
Neoadjuvant Endocrine Therapy ◽  
Free Survival ◽  
Hormone Receptor Positive ◽  
Cancer Subtype ◽  
Prognosis And Prediction

Ki67 is a proliferation marker. It has been proposed as a useful clinical marker for breast cancer subtype classification, prognosis, and prediction of therapeutic response. But the questionable analytical validity of Ki67 prevents its widespread adoption of these measures for treatment decisions in breast cancer. Currently, Ki67 has been tested as a predictive marker for chemotherapy using clinical and pathological response as endpoints in neoadjuvant endocrine therapy. Ki67 can be used as a predictor to evaluate the recurrence-free survival rate of patients, or its change can be used to predict the preoperative “window of opportunity” in neoadjuvant endocrine therapy. In this review, we will elaborate on the role of Ki67 in neoadjuvant endocrine therapy in breast cancer.

scholarly journals Erratum to: Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women

2017 ◽  
Vol 166 (1) ◽  
pp. 195-195 ◽  
Author(s):  
María Elena Martínez ◽  
Scarlett L. Gomez ◽  
Li Tao ◽  
Rosemary Cress ◽  
Danielle Rodriguez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Socioeconomic Factors ◽  
White Women ◽  
Breast Cancer Subtype ◽  
Cancer Subtype ◽  
Hispanic White
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