scholarly journals Herausforderung Adenomyose – operative, endokrine und reproduktionsmedizinische Therapieoptionen

2020 ◽  
Author(s):  
Alexandra S. Kohl Schwartz ◽  
Michael D. Mueller
Keyword(s):  
In Vitro Fertilisation ◽  
Endokrine Therapie ◽  
Down Regulation

ZusammenfassungDie Adenomyose ist durch endometriale Zellen im Myometrium charakterisiert. Zu den klinischen Beschwerden gehören Schmerzen, Blutungsstörungen und beeinträchtigte Fertilität. Die Abklärung beinhaltet eine gute Anamnese und die Bildgebung mit transvaginalem Ultraschall (TVUS) sowie ggf. Magnetresonanztomographie. Klassisch zeigt sich die Adenomyose im TVUS durch partielle Aufhebung der Junktionalzone. Die Therapie erfolgt ganzheitlich und beinhaltet ein gutes Schmerzmanagement. Bei jungen Patientinnen sollte eine endokrine Therapie erfolgen. Die Kinderwunschtherapie kann mit einer 3‑monatigen Down-Regulation mit Gonadotropin-Releasing-Hormon(GnRH)-Analoga eingeleitet werden. Bei notwendiger In-vitro-Fertilisation haben Protokolle mit ultralanger Down-Regulation oder zeitlich versetztem Embryotransfer nach GnRH-Analoga bessere Resultate gezeigt. Bei fortgeschrittener Erkrankung, abgeschlossener Familienplanung oder Therapieresistenz kommt die operative Sanierung oder Hysterektomie infrage.

Comparison of clinical efficacy of long- versus short-acting gonadotrophin-releasing hormone agonists for pituitary down regulation in In vitro fertilisation cycles

2020 ◽  
Vol 27 (3) ◽  
pp. 171
Author(s):  
MaureenUche Umemmuo ◽  
EfenaRuss Efetie ◽  
ChrisOvoroyeguono Agboghoroma ◽  
JafaruAlunua Momoh ◽  
JosephIfeanyichukwu Ikechebelu
Keyword(s):  
Clinical Efficacy ◽  
In Vitro Fertilisation ◽  
Down Regulation ◽  
Short Acting ◽  
Releasing Hormone ◽  
Gonadotrophin Releasing Hormone

The impact of long down regulation in vitro fertilisation cycles on patients' weight

2011 ◽  
Vol 14 (1) ◽  
pp. 23-28 ◽  
Author(s):  
D. Suthersan ◽  
S. Kennedy ◽  
M.G. Chapman Franzcog
Keyword(s):  
In Vitro Fertilisation ◽  
Down Regulation ◽  
The Impact

Down regulation of osteopontin interferes with HCV replication by inhibition of WNT signalling in vitro

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
C Loscher ◽  
R Bartenschlager ◽  
V Lohmann ◽  
G Tiegs ◽  
G Sass
Keyword(s):  
Wnt Signalling ◽  
Down Regulation

Role of 4-O Galloylchlorogenic Acid in Lung Cancer- An Insilico Approach

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Jaynthy C. ◽  
N. Premjanu ◽  
Abhinav Srivastava
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
In Silico ◽  
Computational Study ◽  
Regulation Mechanism ◽  
Down Regulation ◽  
Fruit Extract ◽  
In Vitro Techniques ◽  
Discovery Studio

Cancer is a major disease with millions of patients diagnosed each year with high mortality around the world. Various studies are still going on to study the further mechanisms and pathways of the cancer cell proliferation. Fucosylation is one of the most important oligosaccharide modifications involved in cancer and inflammation. In cancer development increased core fucosylation by FUT8 play an important role in cell proliferation. Down regulation of FUT8 expression may help cure lung cancer. Therefore the computational study based on the down regulation mechanism of FUT8 was mechanised. Sapota fruit extract, containing 4-Ogalloylchlorogenic acid was used as the inhibitor against FUT-8 as target and docking was performed using in-silico tool, Accelrys Discovery Studio. There were several conformations of the docked result, and conformation 1 showed 80% dock score between the ligand and the target. Further the amino acids of the inhibitor involved in docking were studied using another tool, Ligplot. Thus, in-silico analysis based on drug designing parameters shows that the fruit extract can be studied further using in-vitro techniques to know its pharmacokinetics.

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