Cardiovascular risk profiles and 20-year mortality in older people: gender differences in the Pro.V.A. study

AbstractThe age- and gender-related cardio-metabolic changes may limit the applicability of guidelines for the prevention of cardiovascular diseases (CVD) in older people. We investigated the association of cardiovascular risk profile with 20-year all-cause and CVD-mortality in older adults, focusing on age- and gender-specific differences. This prospective study involved 2895 community-dwelling individuals aged ≥65 years who participated in the Pro.V.A study. The sum of achieved target levels (smoking, diet, physical activity, body weight, blood pressure, lipids, and diabetes) recommended by the European Society of Cardiology 2016 guidelines was assessed in each participant. From this sum, cardiovascular risk profile was categorised as very high (0–2), high (3), medium (4), low (5), and very low (6–7 target levels achieved). All-cause and CV mortality data over 20 years were obtained from health registers. At Cox regression, lower cardiovascular risk profile was associated with reduced 20-year all-cause mortality in both genders, with stronger results for women (HR = 0.42 [95%CI:0.25–0.69] and HR = 0.61 [95%CI:0.42–0.89] for very low vs. very high cardiovascular risk profile in women and men, respectively). This trend was more marked for CVD mortality. Lower cardiovascular risk profile was associated with reduced all-cause and CVD mortality only in men < 75 years, while the associations persisted in the oldest old women. A lower cardiovascular risk profile, as defined by current guidelines, may reduce all-cause and CVD mortality in older people, with stronger and longer benefits in women. These findings suggest that personalised and life-course approaches considering gender and age differences may improve the delivery of preventive actions in older people.

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Mild to moderate chronic kidney disease and functional disability in community-dwelling older adults. The Cardiovascular risk profile in Renal patients of the Italian Health Examination Survey (CARHES) study

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2018.10.001 ◽

2019 ◽

Vol 80 ◽

pp. 46-52 ◽

Cited By ~ 1

Author(s):

Giovanni Viscogliosi ◽

Luca De Nicola ◽

Diego Vanuzzo ◽

Simona Giampaoli ◽

Luigi Palmieri ◽

...

Keyword(s):

Older Adults ◽

Chronic Kidney Disease ◽

Cardiovascular Risk ◽

Functional Disability ◽

Risk Profile ◽

Community Dwelling ◽

Health Examination ◽

Cardiovascular Risk Profile ◽

Moderate Chronic Kidney Disease ◽

Community Dwelling Older Adults

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Framingham Risk Stratification of Middle-Aged Migraineurs

Behavioural Neurology ◽

10.1155/2020/7351214 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Gyula Bank ◽

Krisztian Kapus ◽

Janos Meszaros ◽

Kornel Mak ◽

Marietta Pohl ◽

...

Keyword(s):

Blood Pressure ◽

Cardiovascular Risk ◽

High Risk ◽

Migraine With Aura ◽

Risk Profile ◽

Cardiovascular Risk Profile ◽

Middle Aged ◽

Moderate Risk ◽

Diabetes Status ◽

Very High

Introduction. Migraine is a common primary headache disorder involving about 10-15% of the whole population. Several epidemiological and prospective studies showed a link between migraine (especially migraine with aura) and cardio- and cerebrovascular events. Objectives. We prospectively analyzed the data of vascular event-free middle-aged patients with migraine who were referred to our Headache Clinic between 01/2014 and 01/2018. Framingham 10-year risk were calculated; covariates included in the analysis were age, total cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication use, current smoking, and diabetes status. Results. Total of 1037 patients were screened and 221 were selected, 161 were women (mean age 55.5±5.2 years) and 60 were men (mean age 56±6 years). 25 patients (11.3%) were labelled as having low risk, 162 patients (73.3%) had moderate risk, and 34 patients (15.4%) had high or very high risk. Blood pressure and lipid targets were reached in 73% and in 49% in the moderate risk and in 53% and 12% in the high risk/very high risk groups, respectively. Migraine with aura (MA) was associated significantly higher cardiovascular risk profile compared with migraine without aura (MO). About one-third of our nondiabetic patients had fasting blood glucose above the normal levels. 24 patients (mean age 60±4.9 years) were diabetic. Mean blood pressure was 149/85 Hgmm, mean choleterol was 5.11 mmol/l, and mean LDL was 2.93 mmol/l in this subgroup, respectively, which do not fall within the recommended targets. Conclusion. Our article draws attention to the higher cardiovascular risk profile of middle-aged migraineurs and highlights the deficiency of primary prevention. Pain physicians must be aware of the cardiovascular aspects of migraine and holistic approach is required instead of focusing only on pain and pain relief.

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Cardiovascular risk profile of women beyond 45 years of age previously diagnosed with premature ovarian insufficiency compared to premenopausal women of comparable age

10.26226/morressier.573c1514d462b80296c98cc2 ◽

2016 ◽

Author(s):

Nadine Daan

Keyword(s):

Cardiovascular Risk ◽

Premenopausal Women ◽

Risk Profile ◽

Premature Ovarian Insufficiency ◽

Cardiovascular Risk Profile ◽

Ovarian Insufficiency

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Non-Invasive Biomarkers of Musculoskeletal Health with High Discriminant Ability for Age and Gender

Journal of Clinical Medicine ◽

10.3390/jcm10071352 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1352

Author(s):

Sandra Agyapong-Badu ◽

Martin B. Warner ◽

Dinesh Samuel ◽

Vasiliki Koutra ◽

Maria Stokes

Keyword(s):

Physical Function ◽

Peak Flow ◽

Community Dwelling ◽

Thigh Muscle ◽

Musculoskeletal Health ◽

Timed Up And Go ◽

Age And Gender ◽

Linear Discriminant ◽

Anterior Thigh ◽

And Gender

A novel approach to ageing studies assessed the discriminatory ability of a combination of routine physical function tests and novel measures, notably muscle mechanical properties and thigh composition (ultrasound imaging) to classify healthy individuals according to age and gender. The cross-sectional study included 138 community-dwelling, self-reported healthy males and females (65 young, mean age ± SD = 25.7 ± 4.8 years; 73 older, 74.9 ± 5.9 years). Handgrip strength; quadriceps strength; respiratory peak flow; timed up and go; stair climbing time; anterior thigh tissue thickness; muscle stiffness, tone, elasticity (Myoton technology), and self-reported health related quality of life (SF36) were assessed. Stepwise feature selection using cross-validation with linear discriminant analysis was used to classify cases based on criterion variable derived from known effects of age on physical function. A model was trained and features selected using 126 cases with 0.92 accuracy (95% CI = 0.86–0.96; Kappa = 0.89). The final model included five features (peak flow, timed up and go, biceps brachii elasticity, anterior thigh muscle thickness, and percentage thigh muscle) with high sensitivity (0.82–0.96) and specificity (0.94–0.99). The most sensitive novel biomarkers require no volition, highlighting potentially useful tests for screening and monitoring effects of interventions on musculoskeletal health for vulnerable older people with pain or cognitive impairment.

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