Sexual Health, HIV, and Sexually Transmitted Infections among Gay, Bisexual, and Other Men Who Have Sex with Men in the United States

In this study, we assessed if there was a city-level association between sexually transmitted infection (STI) screening intensity in men who have sex with men and antimicrobial sensitivity in Neisseria gonorrhoeae in the United States, 2007 to 2013. We found positive associations between STI screening intensity and increases in minimum inhibitory concentrations for cefixime and azithromycin, but not ceftriaxone when using change in city geometric mean N. gonorrhoeae MIC between 2005 and 2013.

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Addressing sexually transmitted infections in the sociocultural context of black heterosexual relationships in the United States

Social Science & Medicine ◽

10.1016/j.socscimed.2020.113303 ◽

2020 ◽

Vol 263 ◽

pp. 113303 ◽

Cited By ~ 1

Author(s):

Natasha Crooks ◽

Akilah Wise ◽

Tyralynn Frazier

Keyword(s):

United States ◽

Sexually Transmitted Infections ◽

The United States ◽

Sociocultural Context ◽

Heterosexual Relationships ◽

Sexually Transmitted

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Human Immunodeficiency Virus Pre-exposure Prophylaxis and Increased Incidence of Sexually Transmitted Infections in the United States

Clinical Infectious Diseases ◽

10.1093/cid/ciz552 ◽

2019 ◽

Vol 70 (9) ◽

pp. 1884-1890 ◽

Cited By ~ 1

Author(s):

Jose A Serpa ◽

Gabriel N Huynh ◽

Julie B Nickell ◽

Hongyu Miao

Keyword(s):

United States ◽

Human Immunodeficiency Virus ◽

Sexually Transmitted Infections ◽

State Level ◽

The United States ◽

Incidence Rates ◽

Interrupted Time Series Analysis ◽

Sexually Transmitted ◽

Immunodeficiency Virus ◽

Exposure Prophylaxis

Abstract Background Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) decreases HIV transmission. Some studies have raised concerns about a potential association between the implementation of HIV PrEP and the growing incidence rates of sexually transmitted infections (STIs) in the United States. Methods We conducted a quasi-experimental (interrupted time series) analysis of STI (syphilis, gonorrhea, and chlamydia) rates before (2000–2012) and after (2013–2017) the implementation of HIV PrEP. We also performed correlations between HIV PrEP utilization and STI cases at the national (2012–2017) and state (2017) levels. We defined HIV PrEP utilization as the number of people taking tenofovir disoproxil fumarate/emtricitabine for HIV prevention. Results HIV PrEP implementation was associated with 25% (relative risk [RR] 1.254, 95% confidence interval [CI] 1.245–1.263; P < .001) and 26% (RR 1.260, 95% CI 1.257–1.264; P < .001) increases in syphilis and gonorrhea rates, respectively, and a 12% reduction in chlamydia rates (RR: 0.884, 95% CI 0.883–0.885; P < .001). HIV PrEP utilization was correlated with the numbers of syphilis, gonorrhea, and chlamydia cases (spearman coefficients 1.00, 0.94, and 0.94, respectively; P < .001, P < .01, and P < .01, respectively). At the state level, HIV PrEP was also correlated with the number of cases of syphilis, gonorrhea, and chlamydia (spearman coefficients 0.85, 0.81, and 0.85, respectively; Ps < .001 for all correlations). Conclusions The implementation and utilization of HIV PrEP in the United States were associated with increased rates of STIs. Further studies to confirm these associations and to elucidate potential causes are needed.

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Bacterial Sexually Transmitted Infections Among HIV-Infected Patients in the United States

Sexually Transmitted Diseases ◽

10.1097/olq.0000000000000297 ◽

2015 ◽

Vol 42 (6) ◽

pp. 351-352

Author(s):

&NA;

Keyword(s):

United States ◽

Sexually Transmitted Infections ◽

The United States ◽

Sexually Transmitted

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Sexually transmitted infections and sexual behaviors of men who have sex with men in an American Deep South PrEP clinic

International Journal of STD & AIDS ◽

10.1177/0956462419886228 ◽

2020 ◽

Vol 31 (2) ◽

pp. 127-135 ◽

Cited By ~ 1

Author(s):

Ronnie M Gravett ◽

Andrew O Westfall ◽

Edgar T Overton ◽

Kachina Kudroff ◽

Christina A Muzny ◽

...

Keyword(s):

High Risk ◽

Sexually Transmitted Infections ◽

Incidence Rate ◽

Sexual Behaviors ◽

The United States ◽

Sexual Partners ◽

Deep South ◽

Multiple Sexual Partners ◽

Sexually Transmitted ◽

Sex With Men

HIV pre-exposure prophylaxis (PrEP) effectively prevents HIV acquisition among men who have sex with men (MSM), but PrEP uptake has been associated with sexually transmitted infections (STIs). The effect of PrEP on STIs in MSM in the Deep South of the United States is unknown. We performed a retrospective analysis of adult MSM at an American Deep South PrEP clinic to calculate the prevalence and incidence rate of bacterial STIs (chlamydia, gonorrhea, and syphilis) and identify associated risk factors by linking incident STI to patient-reported outcomes; 139 MSM accessed the clinic between 2014 and 2018 with baseline bacterial STI prevalence of 11%. Twenty-six of 81 eligible MSM on PrEP had incident STIs with an incidence rate of 33.1 cases per 100 person-years. Significantly higher proportions of high PrEP adherence, multiple sexual partners, and inconsistent condom use were seen in those with incident STI, and we identified MSM with both high PrEP adherence and multiple sexual partners as being at especially high risk for bacterial STIs (hazard ratio: 7.57, 95% confidence interval: 1.75–32.74). Bacterial STIs are common after initiating PrEP in this clinic, and MSM reporting high PrEP adherence and multiple sexual partners have a significant risk for incident STI. High-risk sexual behaviors persisted after starting PrEP, highlighting the importance of ongoing, intensive sexual health screening and interventions.

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